| 1. |
- Elmroth, Kerstin, 1970, et al.
(författare)
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Radiation and hypothermia: changes in DNA supercoiling in human diploid fibroblasts
- 1999
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Ingår i: Anticancer Res. - 0250-7005 .- 1791-7530. ; 19:6B, s. 5307-11
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Tidskriftsartikel (refereegranskat)abstract
- The influence of hypothermia (2 degrees, 15 degrees and 28 degrees C) upon the effect of X-irradiation on chromatin from human diploid fibroblast cells (AG1518) was studied using the fluorescent halo assay. Rewinding of supercoils was inhibited in a dose-dependent manner when cells were irradiated with 4, 8 or 16 Gy. This inhibition of rewinding was reduced when cells were irradiated at subnormal temperatures compared with cells irradiated at 37 degrees C. One hour's preincubation at low temperature did not influence rewinding. When AG1518 cells were irradiated at 37 degrees C in the presence of the radical scavenger DMSO (0.5 M), the radiation-induced damage was reduced. No additional protection of DMSO in hypothermic cells (2 degrees C) was found, possibly indicating that OH-radical-mediated effects are more temperature dependent. These results are similar to those recently found for the malignant MCF-7 cell line.
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| 2. |
- Lindmark, G, et al.
(författare)
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Limited clinical significance of the serum tumour marker CA 72-4 in colorectal cancer
- 1996
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Ingår i: ANTICANCER RESEARCH. - : INT INST ANTICANCER RESEARCH. - 0250-7005. ; 16:2, s. 895-898
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Tidskriftsartikel (refereegranskat)abstract
- Background: We explored the potential value of CA 72-4 in the staging and prognostic prediction of colorectal cancer, as compared to six previously investigated serum tumour markers - CEA, Ca 19-9, CA 50, CA 242, TPA, and TPS. Materials and Methods: CA 72
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| 3. |
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| 4. |
- Nordstrom, B, et al.
(författare)
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Prognostic index models in stage I and II endometrial carcinoma
- 1998
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Ingår i: ANTICANCER RESEARCH. - : INT INST ANTICANCER RESEARCH. - 0250-7005. ; 18:5B, s. 3717-3724
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Tidskriftsartikel (refereegranskat)abstract
- Background: In most studies, authors recommend the use of independent variables in clinical decision-making, but no guidelines are given about how to use all the extracted information. Materials and Methods: By combining two or three prognostically indepe
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