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- Alanko, V, et al.
(författare)
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Mechanisms Underlying Non-Pharmacological Dementia Prevention Strategies: A Translational Perspective
- 2022
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Ingår i: The journal of prevention of Alzheimer's disease. - : SERDI. - 2426-0266 .- 2274-5807. ; 9:1, s. 3-11
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Tidskriftsartikel (refereegranskat)abstract
- Since developing an effective treatment for Alzheimer’s disease (AD) has been encountered as a challenging task, attempts to prevent cognitive decline by lifestyle modifications have become increasingly appealing. Physical exercise, healthy diet, and cognitive training are all modifiable, non-pharmacological lifestyle factors considered to influence cognitive health. Implementing lifestyle modifications on animal models of AD and cognitive impairment may reveal underlying mechanisms of action by which healthy lifestyle contribute to brain health. In mice, different types of lifestyle interventions have been shown to improve cognitive abilities, alleviate AD-related pathology and neuroinflammation, restore mitochondrial function, and have a positive impact on neurogenesis and cell survival. Different proteins and pathways have been identified to mediate some of the responses, amongst them BDNF, Akt–GSK3β, JNK, and ROCK pathway. Although some important pathways have been identified as mediating improvements in brain health, more research is needed to confirm these mechanisms of action and to improve the understanding of their interplay. Moreover, multidomain lifestyle interventions targeting multiple risk factors simultaneously may be a promising avenue in future dementia prevention strategies. Therefore, future work is needed to better understand the synergistic impact of combinatory lifestyle strategies on cellular mechanisms and brain health.
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- Andersén, Jim, 1976-
(författare)
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What about the employees in entrepreneurial firms? : A multi-level analysis of the relationship between entrepreneurial orientation, role ambiguity, and social support
- 2017
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Ingår i: International Small Business Journal. - : Sage Publications. - 0266-2426 .- 1741-2870. ; 35:8, s. 969-990
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Tidskriftsartikel (refereegranskat)abstract
- Research on entrepreneurial orientation (EO) has mainly addressed outcomes of EO at the level of the firm. However, few studies have examined how EO affects employees. Using a multi-level analysis of 343 employees nested in 25 SMEs, revealed that EO will increase the degree of role ambiguity among employees. Social support from management was not found to have any effect on the relationship between EO and role ambiguity. However, social support from co-workers weakens the EO-ambiguity relationship and can counteract the negative effects of EO to some degree. The study contributes to the EO literature by being one of very few that have considered possible negative consequences of EO, and it also highlights how to reduce role ambiguity in entrepreneurial SMEs.
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- Barron, Andrew, et al.
(författare)
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The financial crisis and the gathering of political intelligence : A cross-country comparison of SMEs in France, Sweden and the UK
- 2010
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Ingår i: International Small Business Journal. - : SAGE. - 0266-2426 .- 1741-2870. ; , s. 1-22
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Tidskriftsartikel (refereegranskat)abstract
- This article reports the findings of a study that compared cross-national differences in how small and medium-sized enterprises (SMEs) monitored political responses to the economic and financial crisis of 2007–2009. Original, empirical data collected through an online survey of 206 small business managers in France, Sweden and the UK were analysed to explore the extent that they monitored policy responses to the crisis, their motivations for doing so, and the sources of information they used for political intelligence gathering purposes. The findings show that the monitoring of political initiatives by SMEs in response to the recession varied in accordance with the extent to which their countries are affected by the recession. Also, small business managers on the whole considered it more important, despite the international nature of the crisis, to monitor political responses in national rather than supranational political settings. Contrary to our expectations, we found that SMEs across all three countries drew on similarly wide sources of information when monitoring policy responses to the crisis. Also surprising was the finding that SME managers in the UK relied heavily on official government sources when gathering intelligence on attempts to alleviate the recession’s effects.
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- Bateman, R J, et al.
(författare)
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Plasma Biomarkers of AD Emerging as Essential Tools for Drug Development: An EU/US CTAD Task Force Report.
- 2019
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Ingår i: The journal of prevention of Alzheimer's disease. - : SERDI. - 2426-0266 .- 2274-5807. ; 6:3, s. 169-173
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Tidskriftsartikel (refereegranskat)abstract
- There is an urgent need to develop reliable and sensitive blood-based biomarkers of Alzheimer's disease (AD) that can be used for screening and to increase the efficiency of clinical trials. The European Union-North American Clinical Trials in Alzheimer's Disease Task Force (EU/US CTAD Task Force) discussed the current status of blood-based AD biomarker development at its 2018 annual meeting in Barcelona, Spain. Recent improvements in technologies to assess plasma levels of amyloid beta indicate that a single sample of blood could provide an accurate estimate of brain amyloid positivity. Plasma neurofilament light protein appears to provide a good marker of neurodegeneration, although not specific for AD. Plasma tau shows some promising results but weak or no correlation with CSF tau levels, which may reflect rapid clearance of tau in the bloodstream. Blood samples analyzed using -omics and other approaches are also in development and may provide important insight into disease mechanisms as well as biomarker profiles for disease prediction. To advance these technologies, international multidisciplinary, multi-stakeholder collaboration is essential.
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- Bengtsson, Maria, et al.
(författare)
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Integrating the Internet and Marketing Operations: A Study of Antecedents in Firms of Different Size
- 2007
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Ingår i: International Small Business Journal. - : SAGE Publications. - 0266-2426 .- 1741-2870. ; 25:1, s. 27-48
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Tidskriftsartikel (refereegranskat)abstract
- Adopting the Internet for advanced marketing operations opens up challenging opportunities for firms of all sizes. However, such adoption might destroy investments in present market channels and thus has the characteristics of radical innovation. In this article, we draw on the literature on innovation to investigate what differentiates adopters of advanced Internet-based marketing operations from non-adopters in firms of different sizes. The conceptual model for this study is centred on the set of internal and external factors size, willingness to cannibalize, entrepreneurial drivers, management support, and market pressure. Our analysis is built on survey data from 379 Swedish manufacturing firms. The results of analysis show that composition of factors on which firms base their decision to adopt advanced Internet-based marketing operations varies signifi cantly with fi rm size. A number of implications for further research as well as for managers and educators are discussed.
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- Bengtsson, Maria, et al.
(författare)
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Managing coopetition to create opportunities for small firms
- 2014
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Ingår i: International Small Business Journal. - : Sage Publications. - 0266-2426 .- 1741-2870. ; 32:4, s. 401-427
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Tidskriftsartikel (refereegranskat)abstract
- This article investigates how coopetition enables Small and Medium-sized Enterprises (SMEs) to create entrepreneurial opportunities in fast-paced industries. The purpose is to explore the managerial challenges that SMEs face when collaborating with large powerful competitors and examine how they balance the relationship to create and sustain business opportunities through coopetition. Based on three exploratory case studies in the IT and telecom industry, we develop a theoretical model suggesting that SME can manage the liabilities of smallness and newness; and sustain independence in and balance coopetitive relationships with large firms if they develop alliance portfolio managing capabilities. We find that the ability to build legitimacy, to enhance agility and to create role flexibility plays an important role in balancing and navigating among different coopetitive relationships, thereby creating and sustaining opportunities.
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