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Stress-related gene...
Stress-related genetic polymorphisms in association with peripartum depression symptoms and stress hormones : A longitudinal population-based study
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- Skalkidou, Alkistis, 1977- (författare)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
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- Sundström Poromaa, Inger, 1964- (författare)
- Uppsala universitet,Reproduktiv hälsa,Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
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- Iliadis, Stavros I., 1983- (författare)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
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- Huizink, Anja (författare)
- Högskolan i Skövde,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Section of Clinical Developmental Psychology, Vrije Universiteit Amsterdam, Netherlands,Kvinna, barn, ungdom och familj, Woman Child Family
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- Hellgren, Charlotte, 1985- (författare)
- Uppsala universitet,Reproduktiv hälsa,Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
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- Freyhult, Eva, 1979- (författare)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin,Science for Life Laboratory, SciLifeLab,Department of Medical Science, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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- Comasco, Erika, 1982- (författare)
- Uppsala universitet,Institutionen för neurovetenskap,Science for Life Laboratory, SciLifeLab,Department of Neuroscience, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- Elsevier Ltd, 2019
- 2019
- Engelska.
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Ingår i: Psychoneuroendocrinology. - : Elsevier Ltd. - 0306-4530 .- 1873-3360. ; 103, s. 296-305
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Individual differences in the response of the stress system to hormonal changes during pregnancy and the postpartum period render some women susceptible to developing depression. The present study sought to investigate peripartum depression and stress hormones in relation to stress-related genotypes. The Edinburgh Postnatal Depression Scale was used to assess peripartum depressive symptoms in a sample of 1629 women, followed from pregnancy week seventeen to six months postpartum. Genotypes of ninety-four haplotype-tag single nucleotide polymorphisms (SNPs) in sixteen genes of the hypothalamus-pituitary-adrenal axis pathway were analyzed and data on psychosocial and demographic factors was collected. In sub-studies, salivary cortisol awakening response in gestational week 35–39, salivary evening cortisol levels in gestational week 36 and postpartum week 6, and blood cortisol and cortisone levels in gestational week 35–39 were analyzed. SNP-set kernel association tests were performed at the gene-level, considering psychosocial and demographic factors, followed by post-hoc analyses of SNPs of significant genes. Statistically significant findings at the 0.05 p-level included SNPs in the hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1) gene in relation to self-rated depression scores in postpartum week six among all participants, and serpin family A member 6 (SERPINA6) gene at the same time-point among women with de novo onset of postpartum depression. SNPs in these genes also associated with stress hormone levels during pregnancy. The present study adds knowledge to the neurobiological basis of peripartum depression by systematically assessing SNPs in stress-regulatory genes and stress-hormone levels in a population-based sample of women. © 2019 Elsevier Ltd
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Cortisol
- Gene
- Hormones
- Hypothalamic-pituitary-adrenal axis
- Perinatal depression
- Postpartum depression
- Single nucleotide polymorphism
- Stress
- Woman, Child and Family (WomFam)
- Kvinna, barn och familj (WomFam)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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