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Sökning: L773:0306 4530 OR L773:1873 3360 > VTI - Statens väg- och transportforskningsinstitut

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1.
  • Sjörs Dahlman, Anna, et al. (författare)
  • Burnout patients' metabolic responses to acute stress
  • 2019
  • Ingår i: Psychoneuroendocrinology. - : Elsevier. - 0306-4530 .- 1873-3360. ; 107, s. 24-25
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • The aim was to use metabolomics to compare metabolic reactions to acute stress between clinical burnout patients and healthy individuals. Fifteen burnout patients (6 women) and 15 controls (8 women) performed the Trier Social Stress Test (TSST). Plasma samples taken before and directly after the TSST were analyzed for metabolite content using gas chromatography time of flight mass spectrometry (GC-TOF-MS). Metabolomics data were analyzed using orthogonal partial least squares-effect projections (OPLS-EP).
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2.
  • Sjörs Dahlman, Anna, et al. (författare)
  • Growth factors and neurotrophins in patients with stress-related exhaustion disorder
  • 2019
  • Ingår i: Psychoneuroendocrinology. - : Elsevier BV. - 0306-4530 .- 1873-3360. ; 109
  • Tidskriftsartikel (refereegranskat)abstract
    • © 2019 The Authors Growth factors, such as vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), and neurotrophic factors, including brain-derived neurotophic factor (BDNF), have attracted attention in studies of the biological effects of long-term stress exposure due to their neuroprotective roles. This study investigated whether circulating levels of EGF, VEGF and BDNF were altered in individuals with stress-related exhaustion disorder. Forty patients diagnosed with exhaustion disorder and 40 healthy subjects (50% women) provided fasting blood samples for analysis of EGF, VEGF, and BDNF in plasma. We found significantly lower levels of EGF, VEGF, and BDNF in patients with ED compared to healthy controls. This pattern was seen in both male and female patients. Given the important roles of BDNF and VEGF for brain plasticity and neurogenesis, decreased levels after long-term stress exposure could indicate increased risk of neuronal damage and cognitive impairments in this patient group.
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  • Resultat 1-2 av 2

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