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1.	Daşu, Alexandru, et al. (author) Secondary malignancies from prostate cancer radiation treatment : a risk analysis of the influence of target margins and fractionation patterns 2011 In: International Journal of Radiation Oncology, Biology, Physics. - : Elsevier BV. - 0360-3016 .- 1879-355X. ; 79:3, s. 738-746 Journal article (peer-reviewed)abstract PURPOSE: This study explores the implications for cancer induction of treatment details such as fractionation, planning target volume (PTV) definition, and interpatient variations, which are relevant for the radiation treatment of prostate carcinomas.METHODS AND MATERIALS: Treatment planning data from 100 patients have been analyzed with a risk model based on the United Nations Scientific Committee on the Effects of Atomic Radiation competition model. The risk model can account for dose heterogeneity and fractionation effects characteristic for modern radiotherapy. Biologically relevant parameters from clinical and experimental data have been used with the model.RESULTS: The results suggested that changes in prescribed dose could lead to a modification of the risks for individual organs surrounding the clinical target volume (CTV) but that the total risk appears to be less affected by changes in the target dose. Larger differences are observed for modifications of the margins between the CTV and the PTV because these have direct impact onto the dose level and dose heterogeneity in the healthy tissues surrounding the CTV. Interpatient anatomic variations also have to be taken into consideration for studies of the risk for cancer induction from radiotherapy.CONCLUSIONS: The results have shown the complex interplay between the risk for secondary malignancies, the details of the treatment delivery, and the patient heterogeneity that may influence comparisons between the long-term effects of various treatment techniques. Nevertheless, absolute risk levels seem very small and comparable to mortality risks from surgical interventions, thus supporting the robustness of radiation therapy as a successful treatment modality for prostate carcinomas.
2.	Widmark, Anders, et al. (author) Extreme Hypofractionation versus Conventionally Fractionated Radiotherapy for Intermediate Risk Prostate Cancer: Early Toxicity Results from the Scandinavian Randomized Phase III Trial “HYPO-RT-PC” 2016 In: International Journal of Radiation Oncology, Biology, Physics, 96 (5), s. 938–939. - : Elsevier BV. - 0360-3016 .- 1879-355X. Conference paper (peer-reviewed)abstract Prostate cancer is postulated to have high radiation-fractionation sensitivity, which suggests a potential therapeutic benefit for hypofractionated (HF) radiotherapy (RT). Results from randomized studies investigating efficacy and side effects of moderately hypofractionated (M-HF) schedules have recently been reported in the literature. Data from randomized trials with extreme hypofractionation (E-HF) are however hitherto lacking. We here report two-year toxicity results from the Scandinavian multicenter phase III trial (HYPO-RT-PC) comparing E-HF with conventional fractionation (CF).

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Type of publication: journal article (1); conference paper (1)

Type of content: peer-reviewed (2)

Author/Editor: Widmark, Anders (2); Franzén, Lars (2); Nilsson, P. (1); Johansson, B (1); Thellenberg Karlsson ... (1); Nilsson, Per (1); show more...; Lagerlund, M (1); Toma-Daşu, Iuliana (1); Fransson, Per (1); Kindblom, Jon, 1969 (1); Kjellén, E (1); Dasu, Alexandru (1); Beckman, L (1); Hoyer, M (1); Gunnlaugsson, A. (1); Ginman, C. (1); Seke, M. (1); Björnlinger, K. (1); show less...

University: Umeå University (2); University of Gothenburg (1); Uppsala University (1); Stockholm University (1); Linköping University (1); Lund University (1); show more...; Karolinska Institutet (1); show less...

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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