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Sökning: L773:0803 5253 > Ritzén M

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  • Hertel, N T, et al. (författare)
  • Growth hormone treatment in 35 prepubertal children with achondroplasia: A five-year dose-response trial
  • 2005
  • Ingår i: Acta Pædiatrica. - : Wiley. - 1651-2227 .- 0803-5253. ; 94:10, s. 1402-1410
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Achondroplasia is a skeletal dysplasia with extreme, disproportionate, short stature. Aim: In a 5-y growth hormone (GH) treatment study including 1 y without treatment, we investigated growth and body proportion response in 35 children with achondroplasia. Methods: Patients were randomized to either 0.1 IU/kg (n=18) or 0.2 IU/kg (n=17) per day. GH treatment was interrupted for 12 mo after 2 y of treatment in prepubertal patients to study catch-down growth. Mean height SDS (HSDS) at start was -5.6 and -5.2 for the low- and high-dose groups, respectively, and mean age 7.3 and 6.6 y. Results: Mean growth velocity (baseline 4.5/4.6 cm/y for the groups) increased significantly by 1.9/3.6 cm/y during the first year and by 0.5/1.5 cm/y during the second year. During the third year, a decrease of growth velocity was observed at 1.9/1.3 cm/y below baseline values. HSDS increased significantly by 0.6/0.8 during the first year of treatment and in total by 1.3/1.6 during the 5 y of study. Sitting height SDS improved significantly from -2.1/-1.7 to -0.8/0.2 during the study. Body proportion (sitting height/total height) or arm span did not show any significant change. Conclusion: GH treatment of children with achondroplasia improves height during 4 y of therapy without adverse effect on trunk-leg disproportion. The short-term effect is comparable to that reported in Turner and Noonan syndrome and in idiopathic short stature.
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  • Jarrett, O. O., et al. (författare)
  • Penile size in healthy Nigerian newborns : country-based reference values and international comparisons
  • 2014
  • Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 103:4, s. 442-446
  • Tidskriftsartikel (refereegranskat)abstract
    • AimTo establish normal reference values for penile size in Nigerian newborn boys and to compare those values with standards from other populations. MethodsA total number of 261 healthy newborn boys delivered at gestational ages of 28weeks or more were enrolled in the study. Penile lengths and widths were measured within 72h of birth. ResultsThe mean (SD) penile length in the 261 Nigerian males studied was 3.4 +/- 0.48cm, while the mean mid-shaft diameter was 1.2 +/- 0.14cm. Compared with data from other populations, Nigerian newborn boys had similar penile sizes to those reported for US Caucasian boys (mean 3.4cm), but significantly greater penile sizes than those reported for boys from China and Hong Kong (mean 3.0 and 3.1cm, respectively; both p<0.001). There was a slight, but significant, difference in size between Nigerian and Malaysian boys, with Malaysian boys having greater penile sizes (mean 3.5cm; p<0.05). ConclusionA Nigerian newborn with a penile length of <2.39cm can be considered to have a micropenis.
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  • Ritzen, M (författare)
  • Treatment of cryptorchidism
  • 2007
  • Ingår i: ACTA PAEDIATRICA. - : Wiley. - 0803-5253 .- 1651-2227. ; 96:9, s. 1370-1370
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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