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Release of theophyl...
Release of theophylline and carbamazepine from matrix tablets - Consequences of HPMC chemical heterogeneity
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- Viridén, Anna, 1977 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Abrahmsén-Alami, Susanna (author)
- AstraZeneca AB
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- Wittgren, Bengt (author)
- AstraZeneca AB
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- Larsson, Anette, 1966 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: European Journal of Mineralogy. - : Elsevier BV. - 0935-1221. ; 78:3, s. 470-479
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Abstract
Subject headings
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- The release of theophylline and carbamazepine from matrix tablets composed of microcrystalline cellulose, lactose and hydroxypropyl methylcellulose (HPMC) was studied. The aim was to investigate the effect of different substituent heterogeneities of HPMC on the drug release from matrix tablets composed of either 35% or 45% HPMC. The release of the poorly soluble carbamazepine was considerably affected by the HPMC heterogeneity, and the time difference at 80% drug release was more than 12 h between the formulations of different HPMC batches. This was explained by slower polymer erosion of the heterogeneous HPMC and the fact that carbamazepine was mainly released by erosion. In addition, results from magnetic resonance imaging showed that the rate of water transport into the tablets was similar. This explained the comparable results of the release of the sparingly soluble theophylline from the two formulations even though the polymer erosion and the swelling of the tablets were considerably different. Thus, it can be concluded that the drug release was highly affected by the substituent heterogeneity, especially in the case of carbamazepine, which was released mainly by erosion. (C) 2011 Elsevier B.V. All rights reserved.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- Hydrophilic matrix tablets
- hydroxypropyl methylcellulose matrices
- MRI
- physicochemical properties
- hydroxypropylmethylcellulose
- Drug solubility
- polymer particle-size
- Drug release
- hydrophilic
- HPMC chemical heterogeneity
- drug-release
- diffusion
- matrices
- delivery-systems
- kinetics
- Batch-to-batch variability
- dissolution
Publication and Content Type
- art (subject category)
- ref (subject category)
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