| 1. |
- Aardal, Elisabeth, et al.
(författare)
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Cortisol in Saliva : Reference Ranges and Relation to Cortisol in Serum
- 1995
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Ingår i: European Journal of Clinical Chemistry and Clinical Biochemistry. - : Walter de Gruyter GmbH. - 0939-4974. ; 33, s. 927-932
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to establish morning and evening reference ranges for cortisol in saliva. Another objective was to compare the concentrations of the mainly free cortisol in saliva to those of total cortisol in serum as determined with a commercial radioimmunoassay. The concentrations were determined in matched samples of saliva and serum collected at 8am and 10pm from 197 healthy volunteers. The saliva samples were stable for at least 7 days at room temperature and for 9 months at —20 °C. Reference ranges, the central 95%, were estimated to 3.5—27.0 nmol/1 at 8 am and < 6.0 nmol/1 at 10 pm. The intra-assay coefficient of variation (CV) was below 5% and total CV below 10%. The relation between the cortisol concentrations in serum and saliva was nonlinear with r = 0.86 for serum concentrations < 450 nmol/1 and r = 0.44 for serum concentrations ^ 450 nmol/1. In conclusion, the satisfactory precision of the analysis and the simple non-invasive sampling procedure suggest that saliva may be used for cortisol measurements in situations where blood sampling is difficult to perform.
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| 2. |
- Ahrén, B, et al.
(författare)
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Potential clinical use of the EDTA-infusion test
- 1993
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Ingår i: European Journal of Clinical Chemistry and Clinical Biochemistry. - 0939-4974. ; 31:6, s. 8-353
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Tidskriftsartikel (refereegranskat)abstract
- The introduction of assays for the intact parathyrin (parathyroid hormone) has dramatically improved the diagnosis and follow-up of patients with primary hyperparathyroidism. However, in some patients with mild or intermittent hypercalcaemia, when plasma concentrations of intact parathyrin may be within the normal reference concentrations, the diagnosis of primary hyperparathyroidism may still be problematic. In these patients, the EDTA-infusion test is of potential value, as it also might be in patients with equivocal operative findings.
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| 3. |
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| 4. |
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| 5. |
- Lubenow, Norbert, et al.
(författare)
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Phenylketonuria screening with a fluorometric microplate assay.
- 1994
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Ingår i: European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. - 0939-4974. ; 32:7, s. 525-8
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Tidskriftsartikel (refereegranskat)abstract
- A fluorometric assay in microtitre plates for the screening of phenylketonuria was evaluated and adapted to a neonatal screening programme. Using this assay, it is possible to determine quantitatively the phenylalanine concentration in dried blood spots on filter paper. The test exhibited a linear calibration curve with a good slope as well as sufficient precision and accuracy in the statistical analysis. Interference by other amino acids and antibiotics was not observed. Only elevated concentrations of leucine interfered to a small degree. The phenylalanine concentration in dried blood spots of 13 phenylketonuria patients correlated to that in serum. 7381 dried blood samples of newborn infants were tested simultaneously by both the fluorometric and the Guthrie test. The results did not show significant differences. We screened 29,182 newborns using the fluorometric assay and an online data processing programme. The internal repetition rate was 0.64%, the external recall rate 0.15%. False negative results were not observed. In December 1991 the fluorometric method replaced the Guthrie test in our routine programme for phenylketonuria screening, and was introduced as a follow up test for phenylketonuria patients.
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| 6. |
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| 7. |
- THUNELL, S, et al.
(författare)
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Markers for vulnerability in acute porphyria. A hypothesis paper
- 1995
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Ingår i: European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. - : Walter de Gruyter GmbH. - 0939-4974. ; 33:4, s. 179-194
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Tidskriftsartikel (refereegranskat)
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