SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:0940 5429 OR L773:1432 5233 "

Sökning: L773:0940 5429 OR L773:1432 5233

  • Resultat 1-10 av 81
  • [1]234567...9Nästa
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Anderbro, Therese, et al. (författare)
  • Fear of hypoglycemia : relationship to hypoglycemic risk and psychological factors
  • 2014
  • Ingår i: Acta Diabetologica. - 0940-5429 .- 1432-5233.
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>OBJECTIVE:</strong> The major aims of this study were to examine (1) the association between fear of hypoglycemia (FOH) in adults with type 1 diabetes with demographic, psychological (anxiety and depression), and disease-specific clinical factors (hypoglycemia history and unawareness, A1c), including severe hypoglycemia (SH), and (2) differences in patient subgroups categorized by level of FOH and risk of SH.</p><p><strong>RESEARCH DESIGN AND METHODS:</strong> Questionnaires were mailed to 764 patients with type 1 diabetes including the Swedish translation of the Hypoglycemia Fear Survey (HFS) and other psychological measures including the Perceived Stress Scale, Hospital Anxiety and Depression Scale, Anxiety Sensitivity Index, Social Phobia Scale, and Fear of Complications Scale. A questionnaire to assess hypoglycemia history was also included and A1c measures were obtained from medical records. Statistical analyses included univariate approaches, multiple stepwise linear regressions, Chi-square t tests, and ANOVAs.</p><p><strong>RESULTS:</strong> Regressions showed that several clinical factors (SH history, frequency of nocturnal hypoglycemia, self-monitoring) were significantly associated with FOH but R (2) increased from 16.25 to 39.2 % when anxiety measures were added to the model. When patients were categorized by level of FOH (low, high) and SH risk (low, high), subgroups showed significant differences in non-diabetes-related anxiety, hypoglycemia history, self-monitoring, and glycemic control.</p><p><strong>CONCLUSION:</strong> There is a strong link between FOH and non-diabetes-related anxiety, as well as hypoglycemia history. Comparison of patient subgroups categorized according to level of FOH and SH risk demonstrated the complexity of FOH and identified important differences in psychological and clinical variables, which have implications for clinical interventions.</p>
  •  
2.
  • Anderbro, Therese, et al. (författare)
  • Fear of hypoglycemia : relationship to hypoglycemic risk and psychological factors
  • 2015
  • Ingår i: Acta Diabetologica. - 0940-5429 .- 1432-5233. ; 52:3, s. 581-589
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The major aims of this study were to examine (1) the association between fear of hypoglycemia (FOH) in adults with type 1 diabetes with demographic, psychological (anxiety and depression), and disease-specific clinical factors (hypoglycemia history and unawareness, A(1c)), including severe hypoglycemia (SH), and (2) differences in patient subgroups categorized by level of FOH and risk of SH. Questionnaires were mailed to 764 patients with type 1 diabetes including the Swedish translation of the Hypoglycemia Fear Survey (HFS) and other psychological measures including the Perceived Stress Scale, Hospital Anxiety and Depression Scale, Anxiety Sensitivity Index, Social Phobia Scale, and Fear of Complications Scale. A questionnaire to assess hypoglycemia history was also included and A(1c) measures were obtained from medical records. Statistical analyses included univariate approaches, multiple stepwise linear regressions, Chi-square t tests, and ANOVAs. Regressions showed that several clinical factors (SH history, frequency of nocturnal hypoglycemia, self-monitoring) were significantly associated with FOH but R (2) increased from 16.25 to 39.2 % when anxiety measures were added to the model. When patients were categorized by level of FOH (low, high) and SH risk (low, high), subgroups showed significant differences in non-diabetes-related anxiety, hypoglycemia history, self-monitoring, and glycemic control. There is a strong link between FOH and non-diabetes-related anxiety, as well as hypoglycemia history. Comparison of patient subgroups categorized according to level of FOH and SH risk demonstrated the complexity of FOH and identified important differences in psychological and clinical variables, which have implications for clinical interventions.</p>
  •  
3.
  • Anderbro, Therese, et al. (författare)
  • Fear of hypoglycemia : relationship to hypoglycemic risk and psychological factors
  • 2015
  • Ingår i: Acta Diabetologica. - 0940-5429 .- 1432-5233. ; 52:3, s. 581-589
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The major aims of this study were to examine (1) the association between fear of hypoglycemia (FOH) in adults with type 1 diabetes with demographic, psychological (anxiety and depression), and disease-specific clinical factors (hypoglycemia history and unawareness, A(1c)), including severe hypoglycemia (SH), and (2) differences in patient subgroups categorized by level of FOH and risk of SH. Questionnaires were mailed to 764 patients with type 1 diabetes including the Swedish translation of the Hypoglycemia Fear Survey (HFS) and other psychological measures including the Perceived Stress Scale, Hospital Anxiety and Depression Scale, Anxiety Sensitivity Index, Social Phobia Scale, and Fear of Complications Scale. A questionnaire to assess hypoglycemia history was also included and A(1c) measures were obtained from medical records. Statistical analyses included univariate approaches, multiple stepwise linear regressions, Chi-square t tests, and ANOVAs. Regressions showed that several clinical factors (SH history, frequency of nocturnal hypoglycemia, self-monitoring) were significantly associated with FOH but R (2) increased from 16.25 to 39.2 % when anxiety measures were added to the model. When patients were categorized by level of FOH (low, high) and SH risk (low, high), subgroups showed significant differences in non-diabetes-related anxiety, hypoglycemia history, self-monitoring, and glycemic control. There is a strong link between FOH and non-diabetes-related anxiety, as well as hypoglycemia history. Comparison of patient subgroups categorized according to level of FOH and SH risk demonstrated the complexity of FOH and identified important differences in psychological and clinical variables, which have implications for clinical interventions.</p>
  •  
4.
  • Bennet, Louise, et al. (författare)
  • Family history of diabetes and its relationship with insulin secretion and insulin sensitivity in Iraqi immigrants and native Swedes a population-based cohort study
  • 2018
  • Ingår i: Acta Diabetologica. - Springer Milan. - 0940-5429 .- 1432-5233. ; 55:3, s. 233-242
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>Aims</strong> Middle Eastern immigrants to western countries are at high risk of developing type 2 diabetes. However, the heritability and impact of rst-degree family history (FH) of type 2 diabetes on insulin secretion and action have not been adequately described. Methods Citizens of Malmö, Sweden, aged 30–75 years born in Iraq or Sweden were invited to participate in this population- based study. Insulin secretion (corrected insulin response and oral disposition index) and action (insulin sensitivity index) were assessed by oral glucose tolerance tests.</p><p><strong>Results</strong> In total, 45.7% of Iraqis (616/1348) and 27.4% of native Swedes (201/733) had FH in parent(s), sibling(s) or single parent and sibling, i.e., FH+. Approximately 8% of Iraqis and 0.7% of Swedes had ≥ 3 sibling(s) and parent(s) with diabetes, i.e., FH++. Irrespective of family size, prediabetes and diabetes increased with family burden (FH− 29.4%; FH+ 38.8%; FH++ 61.7%) without signi cant di erences across ethnicities. With increasing level of family burden, insulin secretion rather than insulin action decreased. Individuals with a combination of ≥ 3 siblings and parents with diabetes presented with the lowest levels of insulin secretion.</p><p><strong>Conclusions</strong> The Iraqi immigrant population often present with a strong familial burden of type 2 diabetes with the worst glycemic control and highest diabetes risk in individuals with ≥ 3 siblings and parents with diabetes. Our data show that in a population still free from diabetes familial burden in uences insulin secretion to a higher degree than insulin action and may be a logical target for intervention. </p>
  •  
5.
  • Benrick, Anna, 1979-, et al. (författare)
  • Enhanced insulin sensitivity and acute regulation of metabolic genes and signaling pathways after a single electrical or manual acupuncture session in female insulin-resistant rats.
  • 2014
  • Ingår i: Acta Diabetologica. - 0940-5429 .- 1432-5233. ; 51:6, s. 963-972
  • Tidskriftsartikel (refereegranskat)abstract
    • AIM: To compare the effect of a single session of acupuncture with either low-frequency electrical or manual stimulation on insulin sensitivity and molecular pathways in the insulin-resistant dihydrotestosterone-induced rat polycystic ovary syndrome (PCOS) model. Both stimulations cause activation of afferent nerve fibers. In addition, electrical stimulation causes muscle contractions, enabling us to differentiate changes induced by activation of sensory afferents from contraction-induced changes. MATERIALS AND METHODS: Control and PCOS rats were divided into no-stimulation, manual-, and electrical stimulation groups and insulin sensitivity was measured by euglycemic hyperinsulinemic clamp. Manually stimulated needles were rotated 180° ten times every 5 min, or low-frequency electrical stimulation was applied to evoke muscle twitches for 45 min. Gene and protein expression were analyzed by real-time PCR and Western blot. RESULTS: The glucose infusion rate (GIR) was lower in PCOS rats than in controls. Electrical stimulation was superior to manual stimulation during treatment but both methods increased GIR to the same extent in the post-stimulation period. Electrical stimulation decreased mRNA expression of Adipor2, Adrb1, Fndc5, Erk2, and Tfam in soleus muscle and increased ovarian Adrb2 and Pdf. Manual stimulation decreased ovarian mRNA expression of Erk2 and Sdnd. Electrical stimulation increased phosphorylated ERK levels in soleus muscle. CONCLUSIONS: One acupuncture session with electrical stimulation improves insulin sensitivity and modulates skeletal muscle gene and protein expression more than manual stimulation. Although electrical stimulation is superior to manual in enhancing insulin sensitivity during stimulation, they are equally effective after stimulation indicating that it is activation of sensory afferents rather than muscle contraction per se leading to the observed changes.
  •  
6.
  • Chisalita, Simona Ioana, et al. (författare)
  • Differential lipid profile and hormonal response in type 2 diabetes by exogenous insulin aspart versus the insulin secretagogue repaglinide, at the same glycemic control
  • 2009
  • Ingår i: Acta Diabetologica. - 0940-5429 .- 1432-5233. ; 46:1, s. 35-42
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Our aim was to study, at the same glycemic control, how treatment with either the insulin secretagogue repaglinide or exogenous insulin aspart affects endogenous insulin secretion, plasma insulin and IAPP (islet amyloid polypeptide) levels, GH-IGF (growth hormone-insulin-like growth factor) axis and plasma lipoprotein concentrations in patients with type 2 diabetes. Five patients, age 65.0 +/- A 4.1 years (mean +/- A SE), body weight 82.5 +/- A 5.0 kg, BMI (body mass index) 27.7 +/- A 1.5 kg/m(2) were treated for 10 weeks with repaglinide or insulin aspart in a randomized, cross-over study. At the end of each treatment a 24-h metabolic profile was performed. Blood glucose, C-peptide, free human insulin, free total (human and analogue) insulin, proinsulin, IAPP, IGF-I, IGFBP-1 (IGF binding protein-1), GHBP (growth hormone binding protein) and plasma lipoprotein concentrations were measured. Similar 24-h blood glucose profiles were obtained with repaglinide and insulin aspart treatment. During the repaglinide treatment, the meal related peaks of C-peptide and free human insulin were about twofold higher than during treatment with insulin aspart. Proinsulin, GHBP were higher and IAPP levels tended to be higher during repaglinide compared to insulin aspart. Postprandial plasma total cholesterol, triglycerides and apolipoprotein B concentrations were higher on repaglinide than on insulin aspart treatment. Our results show that, at the same glycemic control, treatment with exogenous insulin aspart in comparison with the insulin secretagogue repaglinide result in a lower endogenous insulin secretion, and a tendency towards a less atherogenic postprandial lipid profile.</p>
  •  
7.
  • Eriksson, Olof, et al. (författare)
  • Pancreatic imaging using an antibody fragment targeting the zinc transporter type 8 a direct comparison with radio-iodinated Exendin-4
  • 2018
  • Ingår i: Acta Diabetologica. - Springer. - 0940-5429 .- 1432-5233. ; 55:1, s. 49-57
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>AIM:</strong> The zinc transporter 8 (ZnT8) has been suggested as a suitable target for non-invasive visualization of the functional pancreatic beta cell mass, due to both its pancreatic beta cell restricted expression and tight involvement in insulin secretion.</p><p><strong>METHODS:</strong> In order to examine the potential of ZnT8 as a surrogate target for beta cell mass, we performed mRNA transcription analysis in pancreatic compartments. A novel ZnT8 targeting antibody fragment Ab31 was radiolabeled with iodine-125, and evaluated by in vitro autoradiography in insulinoma and pancreas as well as by in vivo biodistribution. The evaluation was performed in a direct comparison with radio-iodinated Exendin-4.</p><p><strong>RESULTS:</strong> Transcription of the ZnT8 mRNA was higher in islets of Langerhans compared to exocrine tissue. Ab31 targeted ZnT8 in the cytosol and on the plasma membrane with 108 nM affinity. Ab31 was successfully radiolabeled with iodine-125 with high yield and &gt; 95% purity. [(125)I]Ab31 binding to insulinoma and pancreas was higher than for [(125)I]Exendin-4, but could only by partially competed away by 200 nM Ab31 in excess. The in vivo uptake of [(125)I]Ab31 was higher than [(125)I]Exendin-4 in most tissues, mainly due to slower clearance from blood.</p><p><strong>CONCLUSIONS:</strong> We report a first-in-class ZnT8 imaging ligand for pancreatic imaging. Development with respect to ligand miniaturization and radionuclide selection is required for further progress. Transcription analysis indicates ZnT8 as a suitable target for visualization of the human endocrine pancreas.</p>
  •  
8.
  • Eriksson, Olof, et al. (författare)
  • Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4
  • 2017
  • Ingår i: Acta Diabetologica. - 0940-5429 .- 1432-5233. ; 54:11, s. 1039-1045
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>AIMS:</strong> Radiolabeled Exendin-4 has been proposed as suitable imaging marker for pancreatic beta cell mass quantification mediated by Glucagon-like peptide-1 receptor (GLP-1R). However, noticeable species variations in basal pancreatic uptake as well as uptake reduction degree due to selective beta cell ablation were observed.</p><p><strong>METHODS:</strong> -Exendin4 Positron Emission Tomography (PET) in the same species. In vitro, ex vivo, and in vivo data formed the basis for calculating the theoretical in vivo contribution of each pancreatic compartment.</p><p><strong>RESULTS:</strong> -Exendin4.</p><p><strong>CONCLUSIONS:</strong> IPR as well as the exocrine GLP-1R density is the main determinants of the species variability in pancreatic uptake. Thus, the IPR in human is an important factor for assessing the potential of GLP-1R as an imaging biomarker for pancreatic beta cells.</p>
  •  
9.
  • Espes, Daniel, 1985-, et al. (författare)
  • Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI
  • 2019
  • Ingår i: Acta Diabetologica. - Springer. - 0940-5429 .- 1432-5233. ; 56:10, s. 1113-1120
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>AIMS:</strong> Perfusion of the pancreas and the islets of Langerhans is sensitive to physiological stimuli and is dysregulated in metabolic disease. Pancreatic perfusion can be assessed by both positron emission tomography (PET) and magnetic resonance imaging (MRI), but the methods have not been directly compared or benchmarked against the gold-standard microsphere technique.</p><p><strong>METHODS:</strong> Pigs (n = 4) were examined by [<sup>15</sup>O]H<sub>2</sub>O PET and intravoxel incoherent motion (IVIM) MRI technique simultaneously using a hybrid PET/MRI scanner. The pancreatic perfusion was measured both at basal conditions and after intravenous (IV) administration of up to 0.5 g/kg glucose.</p><p><strong>RESULTS:</strong> Pancreatic perfusion increased by 35%, 157%, and 29% after IV 0.5 g/kg glucose compared to during basal conditions, as assessed by [<sup>15</sup>O]H<sub>2</sub>O PET, IVIM MRI, and microspheres, respectively. There was a correlation between pancreatic perfusion as assessed by [<sup>15</sup>O]H<sub>2</sub>O PET and IVIM MRI (r = 0.81, R<sup>2</sup> = 0.65, p &lt; 0.01). The absolute quantification of pancreatic perfusion (ml/min/g) by [<sup>15</sup>O]H<sub>2</sub>O PET was within a 15% error of margin of the microsphere technique.</p><p><strong>CONCLUSION:</strong> Pancreatic perfusion by [<sup>15</sup>O]H<sub>2</sub>O PET was in agreement with the microsphere technique assessment. The IVIM MRI method has the potential to replace [<sup>15</sup>O]H<sub>2</sub>O PET if the pancreatic perfusion is sufficiently large, but not when absolute quantitation is required.</p>
  •  
10.
  • Fugmann, Andreas, et al. (författare)
  • Blood flow is an important determinant of forearm glucose uptake following a mixed meal
  • 2003
  • Ingår i: Acta Diabetologica. - 0940-5429 .- 1432-5233. ; 40:3, s. 113-117
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Insulin-mediated vasodilation has been suggested to be of importance for glucose uptake during normoglycemic hyperinsulinemia. If this also is valid after an ordinary mixed meal remains to be evaluated. Forearm blood flow (FBF) and forearm glucose uptake change (evaluated by venous occlusion plethysmography) and glucose arteriovenous differences were evaluated over 120 minutes in 10 healthy volunteers following an ordinary mixed meal (700-900 kcal, 34% of energy from fat). Fasting arterial glucose level was 4.9+/-0.9 mmol/l, and the maximum glucose level was reached 30 minutes after the start of ingestion (6.6+/-0.8 mmol/l, p&lt;0.0001). Plasma insulin levels were increased four-fold. FBF increased rapidly within 20 minutes after the start of ingestion and reached its maximum after 50 minutes (94% higher than baseline level, p&lt;0.01). After 2 hours FBF was still substantially elevated (75% above baseline level, p&lt;0.01). Forearm glucose uptake increased fivefold already after 20 minutes ( p&lt;0.01). During the 2 hours, the increase in FBF contributed to 41% of the forearm glucose uptake ( p&lt;0.05). The present study showed that the increase in FBF seen after an ordinary mixed meal is important for the change in forearm glucose uptake. These results support the view that modulation of limb blood flow is a determinant of glucose uptake.</p>
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 81
  • [1]234567...9Nästa
Åtkomst
fritt online (20)
Typ av publikation
tidskriftsartikel (76)
konferensbidrag (5)
Typ av innehåll
refereegranskat (77)
övrigt vetenskapligt (6)
Författare/redaktör
Lernmark, Åke, (6)
Korsgren, Olle, (4)
LERNMARK, A (4)
Lernmark, Å (4)
Eriksson, Olof, (4)
Bolinder, J, (4)
visa fler...
Neiderud, J (4)
Johansson, C., (3)
Larsson, K (3)
Larsson, A. (3)
CARLSSON, A (3)
Kockum, K (3)
Nilsson, A (3)
Holmberg, E. (3)
Lynch, K (3)
Ivarsson, S-A (3)
Cilio, C M (3)
Johansson, Unn-Britt ... (3)
Ivarsson, Sten A (3)
Carlsson, E. (3)
Lisspers, Jan, (3)
Anderbro, Therese, (3)
Wredling, Regina, (3)
Lins, Per-Eric (3)
Moberg, Erik (3)
Gonder-Frederick, Li ... (3)
Bolinder, Jan, (3)
Ludvigsson, J (3)
Wändell, P, (3)
Gustavsson, I (3)
Carlsson, A. C. (3)
Ruge, T (3)
Melander, O, (3)
Thalme, B (3)
Jönsson, B.A., (3)
Sjöblad, S (3)
Larsson, H. E. (3)
Wessman, T, (3)
Tullus, K (3)
Segnestam, K (3)
Myrdal, U (3)
Hellgren, H., (3)
Aili, M (3)
Edenwall, H (3)
Hellenberg, L (3)
Jonsell, G (3)
Lindh, A (3)
Skogsberg, L (3)
Strömberg, L (3)
Wallensteen, M (3)
visa färre...
Lärosäte
Lunds universitet (23)
Karolinska Institutet (23)
Uppsala universitet (10)
Göteborgs universitet (9)
Umeå universitet (7)
Linköpings universitet (5)
visa fler...
Örebro universitet (2)
Luleå tekniska universitet (1)
Högskolan Kristianstad (1)
Stockholms universitet (1)
Högskolan i Jönköping (1)
Mittuniversitetet (1)
Sophiahemmet Högskola (1)
Högskolan Dalarna (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (79)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (57)
Samhällsvetenskap (1)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy