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Sökning: L773:0940 5429 OR L773:1432 5233 > Övrigt vetenskapligt/konstnärligt

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  • Granlund, Louise, 1992-, et al. (författare)
  • Extra-islet cells expressing insulin or glucagon in the pancreas of young organ donors
  • Ingår i: Acta Diabetologica. - 0940-5429 .- 1432-5233.
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Aims: The existence of insulin- or glucagon-expressing extra-islet endocrine cells scattered in the pancreas is well-known, but they have been sparsely characterized. The aim of this study was to examine their density, distribution, transcription-factor expression, and mitotic activity in young non-diabetic subjects.Methods: Multispectral imaging was used to examine PDX1, ARX, Ki67, insulin and glucagon in extra-islet endocrine cells in pancreatic tissue from organ donors aged 1-25 years.Results: Extra-islet insulin- or glucagon-positive cells were frequent in all donors (median 17.3 and 22.9 cells/mm2 respectively), with an insulin:glucagon cell ratio of 0.9. The density was similar regardless of age. PDX1 localized mainly to insulin-, and ARX mainly to glucagon-positive cells but, interestingly, many of the cells were negative for both transcription factors. Double-hormone-positive cells were rare but found in all age groups, as were insulin-positive cells expressing ARX and glucagon-positive cells expressing PDX1. Extra-islet endocrine cells with Ki67 expression were present but rare in all age groups (0-2%).Conclusions: Extra-islet endocrine cells are more frequent than islets. The preserved density during pancreas expansion from childhood- to adulthood indicates that new cells are formed, likely from replication, as cells with mitotic activity were discovered. The lack of transcription-factor expression in many cells could indicate that they are immature, newly formed or plastic. This, together with the mitotic activity, suggest that these cells play an important role in the expansion of beta-cell mass in situations of increasing demand, or in the turnover of the endocrine cell population.
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  • Dahlöf, Björn, 1953, et al. (författare)
  • Introduction
  • 2005
  • Ingår i: Acta Diabetol. - 0940-5429. ; 42 Suppl 1
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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