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Explorative study o...
Explorative study on the predictive value of systematic inflammatory and metabolic markers on weight loss in head and neck cancer patients undergoing radiotherapy
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- Ehrsson, Ylva Tiblom (författare)
- Dept Clin Neurosci, Karolinska Inst, Stockholm, Sweden,Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
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- Hellström, Per M., 1954- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Gastroenterologi/Hellström,Dept Med Sci, Univ Uppsala Hosp, Uppsala, Sweden,Department of Medical Science, Uppsala University Hospital, 751 85 Uppsala, Sweden
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- Brismar, Kerstin (författare)
- Karolinska Institutet
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- Sharp, Lena (författare)
- Karolinska Institutet
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- Langius-Eklöf, Ann (författare)
- Karolinska Institutet,Örebro universitet,Hälsoakademin,School of Medical and Health Sciences, Örebro University, 701 82 Örebro, Sweden
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- Laurell, Göran (författare)
- Umeå universitet,Öron- näs- och halssjukdomar
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(creator_code:org_t)
- 2009-10-15
- 2010
- Engelska.
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Ingår i: Supportive Care in Cancer. - : Springer Science and Business Media LLC. - 0941-4355 .- 1433-7339. ; 18:11, s. 1385-1391
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Purpose This study aimed to explore the predictive value of systematic inflammatory and metabolic markers in head and neck (H&N) cancer patients during radiotherapy (RT). Methods Twenty-seven patients were evaluated. The protocol included serial blood tests [highly sensitive C-reactive protein (hsCRP), albumin, insulin-like growth factor 1 (IGF-1), IGF binding protein 1 (IGFBP-1) and ghrelin], measurements of body weight and assessment of oral mucositis. Results The mean nadir of weight loss was observed at the end of RT. At the time of diagnosis, mean hsCRP was 5.2 +/- 1.0 mg/L. HsCRP significantly increased during RT and decreased during the post-RT period. Mean maximum hsCRP was 35.8 +/- 8.5 mg/L, with seven patients reaching >40 mg/L. A numerical decrease of albumin (by 18.2%) and only small changes in IGF-1, IGFBP-1 and ghrelin levels were observed. None of the metabolic parameters was significantly associated with weight loss. Conclusions HsCRP increased in response to RT for H&N cancer as a sign of irradiation-induced inflammation. Weight loss was not preceded by changes of the metabolic parameters, indicating that assessment of the blood markers used in this study is of little value. Regular body weight measurement and assessment of oral mucositis are feasible, cheap and important procedures to control the metabolic homeostasis during RT.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Highly sensitive C-reactive protein
- Albumin
- Insulin-like growth factor 1
- Insulin-like growth factor binding protein 1
- Ghrelin
- Weight loss
- MEDICINE
- MEDICIN
- Medical Science
- Medicinsk vetenskap
- Oncology
- Onkologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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