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Träfflista för sökning "L773:0959 8278 ;pers:(Hallmans Göran)"

Search: L773:0959 8278 > Hallmans Göran

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1.	Bylund, A, et al. (author) Randomised controlled short-term intervention pilot study on rye bran bread in prostate cancer. 2003 In: European Journal of Cancer Prevention. - 0959-8278 .- 1473-5709. ; 12:5, s. 407-415 Journal article (peer-reviewed)
2.	Rinaldi, Sabina, et al. (author) IGF-I, IGFBP-3 and breast cancer in young women: a pooled re-analysis of three prospective studies 2005 In: European Journal of Cancer Prevention. - 0959-8278. ; 14:6, s. 493-496 Journal article (peer-reviewed)
3.	Van Guelpen, Bethany, et al. (author) Polymorphisms of methylenetetrahydrofolate reductase and the risk of prostate cancer : a nested case-control study 2006 In: European Journal of Cancer Prevention. - : Lippincott Williams & Wilkins. - 0959-8278 .- 1473-5709. ; 15:1, s. 46-50 Journal article (peer-reviewed)abstract It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate from DNA synthesis and repair to methylation reactions, are involved in the aetiology of cancer. To relate the MTHFR 677C→T and 1298A→C polymorphisms to the risk of prostate cancer, taking into consideration prospective plasma levels of folate, vitamin B12 and homocysteine. The design was a case-control study of 223 prostate cancer cases and 435 matched controls nested within the population-based Northern Sweden Health and Disease Cohort. Neither the MTHFR 677C→T nor the MTHFR 1298A→C polymorphism was statistically significantly associated with the risk of prostate cancer in univariate analysis by conditional logistic regression. After adjustment for MTHFR 1298A→C, plasma folate, vitamin B12, homocysteine, body mass index and smoking, the odds ratios were, for the 677 CT genotype, 1.52 [95% confidence interval (CI) 1.02-2.26], and for TT, 0.91 (95% CI 0.41-2.04). Our previously reported observation of a possible increase in the risk of prostate cancer at high plasma folate levels was attributable in this study to subjects having the MTHFR 677C→T polymorphism. We found that the MTHFR 677C→T polymorphism is not likely to have a major role in the development of prostate cancer, although it may possibly increase the risk in combination with high plasma folate levels. Further investigation in larger studies is warranted.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Hallmans, Göran (3)Undo refine; Stattin, Pär (2); Kaaks, Rudolf (1); Krogh, Vittorio (1); Lenner, Per (1); Riboli, Elio (1); show more...; Kaaks, R. (1); Nordin, A (1); Lundin, Eva (1); Bergh, Anders (1); Stattin, P (1); Lukanova, Annekatrin (1); van Guelpen, Bethany (1); Rinaldi, Sabina (1); Berrino, Franco (1); Dossus, Laure (1); Zeleniuch-Jacquotte, ... (1); Hultdin, Johan (1); Koenig, Karen L. (1); Shore, Roy E. (1); Toniolo, Paolo (1); Micheli, Andrea (1); Muti, Paola (1); Bergh, A (1); Nilsson, T.K. (1); Lundin, E. (1); Stenman, U H (1); Zhang, Jie-Xian (1); Bylund, A (1); Aman, P (1); Adlercreutz, H (1); Arslan, Alan (1); Wirén, Sara, 1981- (1); show less...

University: Umeå University (3)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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