Intracranial and subcortical volumes in adolescents with early‐onset psychosis: A multisite mega‐analysis from the ENIGMA consortium

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Intracranial and subcortical volumes in adolescents with early‐onset psychosis : A multisite mega‐analysis from the ENIGMA consortium

Gurholt, Tiril P. (author): Norwegian Center for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction Oslo University Hospital Oslo Norway;Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway;Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway

Lonning, Vera (author): Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway;Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway

Nerland, Stener (author): Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway;Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway

Jørgensen, Kjetil N. (author): Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway;Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway

Haukvik, Unn K. (author): Norwegian Center for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction Oslo University Hospital Oslo Norway;Department of Adult Mental Health, Institute of Clinical Medicine University of Oslo Oslo Norway

Alloza, Clara (author): Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM Madrid Spain

Arango, Celso (author): Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM Madrid Spain;School of Medicine Universidad Complutense Madrid Spain

Barth, Claudia (author): Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway

Bearden, Carrie E. (author): Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior UCLA Los Angeles California USA;Department of Psychology UCLA Los Angeles California USA

Berk, Michael (author): IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University Geelong Victoria Australia;Orygen Youth Health Research Center The Florey Institute for Neuroscience and Department of Psychiatry Parkville Victoria Australia

Bohman, Hannes, 1965- (author): Karolinska Institutet,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Ramklint: Barn- och ungdomspsykiatri,Center for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet and Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden Stockholm Sweden;Department of Clinical Science and Education Södersjukhuset Karolinska Institutet Stockholm Sweden,Ulf Jonsson

Dandash, Orwa (author): IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University Geelong Victoria Australia

Díaz‐Caneja, Covadonga M. (author): Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM Madrid Spain;School of Medicine Universidad Complutense Madrid Spain

Edbom, Carl T. (author): Center for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet and Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden Stockholm Sweden

Erp, Theo G. M. (author): Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior University of California Irvine Irvine California USA;Center for the Neurobiology of Learning University of California Irvine and Memory Irvine California USA

Fett, Anne‐Kathrin J. (author): Department of Psychology City, University of London London UK;Department of Psychosis Studies IoPPN London UK;Department of Clinical, Neuro and Developmental Psychology VU Amsterdam Amsterdam Netherlands

Frangou, Sophia (author): Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York USA

Goldstein, Benjamin I. (author): Center for Youth Bipolar Disorder, Sunnybrook Health Science Center Toronto Ontario Canada;Department of Psychiatry and Pharmacology University of Toronto Canada

Grigorian, Anahit (author): Center for Youth Bipolar Disorder, Sunnybrook Health Science Center Toronto Ontario Canada

Jahanshad, Neda (author): Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California Marina del Rey California USA

James, Anthony C. (author): Department of Psychiatry University of Oxford Oxford UK;Oxford Health Foundation NHS Trust Oxford UK

Janssen, Joost (author): Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM Madrid Spain;School of Medicine Universidad Complutense Madrid Spain

Johannessen, Cecilie (author): Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway

Karlsgodt, Katherine H. (author): Department of Psychology UCLA Los Angeles California USA;Department Psychiatry and Biobehavioral Sciences UCLA Los Angeles California USA

Kempton, Matthew J. (author): Department of Psychosis Studies King's College London London UK

Kochunov, Peter (author): Maryland Psychiatric Research Center, Department of Psychiatry University of Maryland School of Medicine Baltimore Maryland USA

Krabbendam, Lydia (author): Department of Clinical, Neuro and Developmental Psychology VU Amsterdam Amsterdam Netherlands

Kyriakopoulos, Marinos (author): Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience King's College London London UK;National and Specialist Children's Inpatient Unit (Acorn Lodge), South London and Maudsley NHS Foundation Trust Beckenham UK

Lundberg, Mathias (author): Karolinska Institutet,Uppsala universitet,Ramklint: Barn- och ungdomspsykiatri,Center for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet and Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden;Department of Neuroscience, Department of Clinical Science and Education Södersjukhuset Karolinska Institutet Stockholm Sweden;The Department of Clinical Science and Education KI SÖS Stockholm Sweden

MacIntosh, Bradley J. (author): Hurvitz Brain Sciences, Sunnybrook Research Institute Toronto Ontario Canada;Department of Medical Biophysics University of Toronto Ontario Canada

Rund, Bjørn Rishovd (author): Department of Psychology University of Oslo Oslo Norway;Department of Research Vestre Viken Hospital Trust Drammen Norway

Smelror, Runar E. (author): Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway;Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway

Sultan, Alysha (author): Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York USA;Department of Pharmacology University of Toronto Toronto Ontario Canada

Tamnes, Christian K. (author): Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway;Department of Psychiatric Research Diakonhjemmet Hospital Oslo Norway;PROMENTA Research Center, Department of Psychology University of Oslo Oslo Norway

Thomopoulos, Sophia I. (author): Department of Psychiatry and Pharmacology University of Toronto Canada

Vajdi, Ariana (author): Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior UCLA Los Angeles California USA

Wedervang‐Resell, Kirsten (author): Norwegian Center for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction Oslo University Hospital Oslo Norway

Myhre, Anne M. (author): Child and Adolescent Psychiatry Unit, Division of Mental Health and Addiction, Institute of Clinical Medicine University of Oslo Oslo Norway;Department of Psychiatric Research and Development, Division of Mental Health and Addiction Oslo University Hospital Oslo Norway

Andreassen, Ole A. (author): Norwegian Center for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction Oslo University Hospital Oslo Norway;Norwegian Center for Mental Disorders Research (NORMENT), Institute of Clinical Medicine University of Oslo Oslo Norway

Thompson, Paul M. (author): Department of Psychiatry and Pharmacology University of Toronto Canada

Agartz, Ingrid (author): Karolinska Institutet

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2020-10-05
2020
English.
In: Human Brain Mapping. - Stockholm : Wiley. - 1065-9471 .- 1097-0193. ; 43:1, s. 373-384

Related links:: https://doi.org/10.1...; show more...; https://uu.diva-port... (primary) (Raw object); https://onlinelibrar...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; https://urn.kb.se/re...; show less...

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Abstract Subject headings

Early-onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest neuroimaging dataset, to date, of patients with early-onset psychosis and healthy controls for differences in intracranial and subcortical brain volumes. The sample included 263 patients with early-onset psychosis (mean age: 16.4 ± 1.4 years, mean illness duration: 1.5 ± 1.4 years, 39.2% female) and 359 healthy controls (mean age: 15.9 ± 1.7 years, 45.4% female) with magnetic resonance imaging data, pooled from 11 clinical cohorts. Patients were diagnosed with early-onset schizophrenia (n = 183), affective psychosis (n = 39), or other psychotic disorders (n = 41). We used linear mixed-effects models to investigate differences in intracranial and subcortical volumes across the patient sample, diagnostic subgroup and antipsychotic medication, relative to controls. We observed significantly lower intracranial (Cohen's d = −0.39) and hippocampal (d = −0.25) volumes, and higher caudate (d = 0.25) and pallidum (d = 0.24) volumes in patients relative to controls. Intracranial volume was lower in both early-onset schizophrenia (d = −0.34) and affective psychosis (d = −0.42), and early-onset schizophrenia showed lower hippocampal (d = −0.24) and higher pallidum (d = 0.29) volumes. Patients who were currently treated with antipsychotic medication (n = 193) had significantly lower intracranial volume (d = −0.42). The findings demonstrate a similar pattern of brain alterations in early-onset psychosis as previously reported in adult psychosis, but with notably low intracranial volume. The low intracranial volume suggests disrupted neurodevelopment in adolescent early-onset psychosis.

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By the author/editor: Gurholt, Tiril P ...; Lonning, Vera; Nerland, Stener; Jørgensen, Kjeti ...; Haukvik, Unn K.; Alloza, Clara; show more...; Arango, Celso; Barth, Claudia; Bearden, Carrie ...; Berk, Michael; Bohman, Hannes, ...; Dandash, Orwa; Díaz‐Caneja, Cov ...; Edbom, Carl T.; Erp, Theo G. M.; Fett, Anne‐Kathr ...; Frangou, Sophia; Goldstein, Benja ...; Grigorian, Anahi ...; Jahanshad, Neda; James, Anthony C ...; Janssen, Joost; Johannessen, Cec ...; Karlsgodt, Kathe ...; Kempton, Matthew ...; Kochunov, Peter; Krabbendam, Lydi ...; Kyriakopoulos, M ...; Lundberg, Mathia ...; MacIntosh, Bradl ...; Rund, Bjørn Rish ...; Smelror, Runar E ...; Sultan, Alysha; Tamnes, Christia ...; Thomopoulos, Sop ...; Vajdi, Ariana; Wedervang‐Resell ...; Myhre, Anne M.; Andreassen, Ole ...; Thompson, Paul M ...; Agartz, Ingrid; show less...

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Intracranial and subcortical volumes in adolescents with early‐onset psychosis : A multisite mega‐analysis from the ENIGMA consortium

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