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Träfflista för sökning "L773:1078 0432 OR L773:1557 3265 ;pers:(Ostman A)"

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1.	Tobin, N. P., et al. (author) An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors 2016 In: Clinical Cancer Research. - : American Association for Cancer Research (AACR). - 1078-0432 .- 1557-3265. ; 22:10, s. 2417-2426 Journal article (peer-reviewed)abstract Purpose: The ability of vascular genes to provide treatment predictive information in breast cancer patients remains unclear. As such, we assessed the expression of genes representative of normal endothelial microvasculature (MV) in relation to treatment-specific patient subgroups. Experimental Design: We used expression data from 993 breast tumors to assess 57 MV genes (summarized to yield an MV score) as well as the genomic grade index (GGI) and PAM50 signatures. MV score was compared with CD31 staining by correlation and gene ontology (GO) analysis, along with clinicopathologic characteristics and PAM50 subtypes. Uni-, multivariate, and/or t-test analyses were performed in all and treatment-specific subgroups, along with a clinical trial cohort of patients with metastatic breast cancer, seven of whom received antiangiogenic therapy. Results: MV score did not correlate with microvessel density (correlation = 0.096), but displayed enrichment for angiogenic GO terms, and was lower in Luminal B tumors. In endocrine-treated patients, a high MV score was associated with decreased risk of metastasis [HR 0.58; 95% confidence interval (CI), 0.38-0.89], even after adjusting for histologic grade, but not GGI or PAM50. Subgroup analysis showed the prognostic strength of the MV score resided in low genomic grade tumors and MV score was significantly increased in metastatic breast tumors after treatment with sunitinib + docetaxel (P = 0.031). Conclusions: MV score identifies two groups of better and worse survival in low-risk endocrine-treated breast cancer patients. We also show normalization of tumor vasculature on a transcriptional level in response to an angiogenic inhibitor in human breast cancer samples. (C) 2016 AACR.
2.	Baranowska-Kortylewicz, J, et al. (author) Effects of STI571 on radioimmunotherapy of colorectal cancer. 2003 In: CLINICAL CANCER RESEARCH. - 1078-0432. ; 9:16, s. 6189S-6189S Conference paper (other academic/artistic)
3.	Ehnman, M, et al. (author) IGFBP5 is induced by tumor-suppressive naive stromal cells and regulates GAS2-associated apoptosis in rhabdomyosarcoma 2022 In: CLINICAL CANCER RESEARCH. - 1078-0432. ; 28:18, s. 5-6 Conference paper (other academic/artistic)
4.	Ehnman, M, et al. (author) IGFBP5 is induced by tumor-suppressive naive stromal cells and regulates GAS2-associated apoptosis in rhabdomyosarcoma 2022 In: CLINICAL CANCER RESEARCH. - 1078-0432. ; 28:18 Conference paper (other academic/artistic)
5.	Micke, P, et al. (author) A laser capture and microarray based approach to elucidate the interaction of cancer associated fibroblasts and tumor cells. 2003 In: CLINICAL CANCER RESEARCH. - 1078-0432. ; 9:16, s. 6120S-6120S Conference paper (other academic/artistic)
6.	Micke, P, et al. (author) In situ gene expression profiling of cancer-associated fibroblasts. 2005 In: CLINICAL CANCER RESEARCH. - 1078-0432. ; 11:24, s. 9000S-9000S Conference paper (other academic/artistic)
7.	Pietras, K, et al. (author) Interference with PDGF receptor signaling enhances the effect of chemotherapy on solid tumors by increasing drug uptake. 2001 In: CLINICAL CANCER RESEARCH. - 1078-0432. ; 7:11, s. 3751S-3751S Conference paper (other academic/artistic)
8.	Pietras, K, et al. (author) STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake 2003 In: Clinical cancer research : an official journal of the American Association for Cancer Research. - 1078-0432. ; 9, s. 3779- Journal article (peer-reviewed)
9.	Robinson, SP, et al. (author) The role of platelet-derived growth factor on tumour vascular function and morphology in vivo assessed by susceptibility magnetic resonance imaging. 2005 In: CLINICAL CANCER RESEARCH. - 1078-0432. ; 11:24, s. 9128S-9128S Conference paper (other academic/artistic)

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Result 1-9 of 9

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Type of publication: conference paper (7); journal article (2)

Type of content: other academic/artistic (7); peer-reviewed (2)

Author/Editor: Ostman, A (9)Undo refine; Pietras, K (3); Zhang, Y. (2); Tobin, N. (2); Ponten, F. (2); Lindahl, P. (2); show more...; Micke, P (2); Ehnman, M (2); Heldin, CH (2); Katkhada, K (2); Meng, LZ (2); Zhao, BB (2); Tong, SL (2); Kallai, A (2); Scheidl, S (2); Buchdunger, E (2); Bergh, J (1); Landberg, Göran (1); Abe, M (1); Betsholtz, Christer, ... (1); Heldin, Carl-Henrik (1); Rubin, K (1); Rubin, Kristofer (1); Paulsson, J (1); Genove, G (1); Sundquist, C. (1); Augsten, M (1); Baranowska-Kortylewi ... (1); Kurizaki, T (1); Kortylewicz, ZP (1); Enke, CA (1); Kappert, K (1); Foukakis, T (1); Sjoquist, M (1); Hagerstrand, D (1); Robinson, SP (1); Ohshima, M (1); HUBERT, M (1); Ludwig, C. (1); Wennmalm, K (1); Lindstrom, L. S. (1); He, L. Q. (1); Sjoblom, T (1); Tobin, N. P. (1); Stolz, C (1); Heldin, C (1); McSheehy, P (1); Wartmann, M (1); Stumm, M (1); show less...

University: Karolinska Institutet (8); University of Gothenburg (1); Uppsala University (1)

Language: English (9)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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