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- Wilczek, Michael L., et al.
(författare)
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Mammography and Osteoporosis Screening-Clinical Risk Factors and Their Association With Digital X-Ray Radiogrammetry Bone Mineral Density
- 2015
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Ingår i: Journal of clinical densitometry. - : Elsevier. - 1094-6950 .- 1559-0747. ; 18:1, s. 22-29
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to study the association between digital X-ray radiogrammetry (DXR) T-score and clinical risk factors for osteoporosis. Women were recruited 2 d per wk at a single mammography screening center between year 2010 and 2012. Included women answered a questionnaire about risk factors for osteoporosis, and a radiograph of the nondominant hand was obtained for DXR analysis. Univariate associations between DXR T-score and risk factors were examined. A generalized linear regression model was fitted to independent variables with univariate associations at p less than 0.05. The multivariable model was reduced through manual backward elimination, with p greater than 0.1 as the exclusion criterion. Seventy-six percent of the women chose to participate in the study (n = 8810). The difference in number of daily mammograms performed on study vs nonstudy days was not significant. All univariate associations between DXR T-score and potential risk factors were highly significant. The multivariable model included height, weight, age, right-handedness, menopause before age 45, alcohol consumption, cortisone treatment, rheumatic disease, and age x smoking status. The coefficient of determination of the model was 0.37. The association between risk factors for osteoporosis and DXR T-score is similar to previously reported associations with dual-energy X-ray absorptiometry.
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| 2. |
- Kanis, JA, et al.
(författare)
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The perspective of the International Osteoporosis Foundation on the official positions of the International Society for Clinical Densitometry
- 2005
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Ingår i: Journal of Clinical Densitometry. - 1094-6950. ; 8:2, s. 145-147
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Tidskriftsartikel (refereegranskat)abstract
- The International Society for Clinical Densitometry (ISCD) has published position statements on topics relating to the use and interpretation of measurements of bone mineral density (BMD). The most recent appeared in the Journal of Clinical Densitometry (1) and was republished in the Journal of Endocrinology and Metabolism and in Osteoporosis International (2,3). The topics included the indications for testing with BMD, the use of central dual energy X-ray absorptiometry (DXA) for the diagnosis of osteoporosis, the use of the Z-score and some recommendations for the spelling of the T-score and Z-score. Although these topics were chosen in an attempt to produce international consistency and consensus, most of the position statements lack a scientific basis.
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| 3. |
- Callréus, Mattias, et al.
(författare)
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Country-Specific Young Adult Dual-Energy X-Ray Absorptiometry Reference Data Are Warranted for T-Score Calculations in Women: Data From the Peak-25 Cohort.
- 2014
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Ingår i: Journal of Clinical Densitometry. - : Elsevier BV. - 1094-6950. ; 17:1, s. 129-135
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Tidskriftsartikel (refereegranskat)abstract
- The aims of this study were to provide normative data for dual-energy X-ray absorptiometry (DXA) in 25-yr-old women and evaluate whether young adult Swedish women have bone mineral density (BMD) comparable with DXA manufacturer reference values and other equivalent populations. BMD at all sites was measured in the population-based Peak-25 cohort (n = 1061 women; age, 25.5 ± 0.2yr). BMD values were standardized (sBMD) and compared against the Third National Health and Nutrition Examination Survey (NHANES III) and other cohorts. Based on the DXA manufacturer-supplied reference values, Z-scores were 0.54 ± 0.98 (femoral neck [FN]), 0.47 ± 0.96 (total hip [TH]), and 0.32 ± 1.03 (lumbar spine [LS]). In comparison with other studies, sBMD was higher in the Peak-25 cohort (FN, 1.5%-8.3%; TH, 3.9%-9.2%; and LS, 2.4%-6.5%) with the exception of trochanter-sBMD which was 2.5% lower compared with NHANES III. The concordance in identifying those in the lowest or highest quartile of BMD was highest between hip measurements (low, 71%-78% and high, 70%-84%), corresponding discordance of 0%-1%. At this age, the correlation between DXA sites was strong (r = 0.62-0.94). BMD in Swedish young adult women is generally higher than has been reported in other equivalently aged European and North American cohorts and suggests that the high fracture incidence in Sweden is not explained by lower peak bone mass. The use of nonregional-specific DXA reference data could contribute to misdiagnosed osteoporosis in elderly women.
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| 8. |
- Karlsson, Magnus, et al.
(författare)
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An Increase in Forearm Cortical Bone Size After Menopause May Influence the Estimated Bone Mineral Loss-A 28-Year Prospective Observational Study.
- 2016
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Ingår i: Journal of Clinical Densitometry. - : Elsevier BV. - 1094-6950. ; 19:2, s. 174-179
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Tidskriftsartikel (refereegranskat)abstract
- Areal bone mineral density (aBMD) is the most common estimate of bone mass, incorporated in the World Health Organization definition of osteoporosis. However, aBMD depends on not only the amount of mineral but also the bone size. The estimated postmenopausal decline in aBMD could because of this be influenced by changes in bone size.We measured bone mineral content (BMC; mg), aBMD (mg/cm(2)), and bone width (mm) by single-photon absorptiometry at the cortical site of the forearm in a population-based sample of 105 Caucasian women. We conducted 12 measurements during a 28-yr period from mean 5 yr (range: 2-9) before menopause to mean 24 yr (range: 18-28) after menopause. We calculated individual slopes for changes in the periods before menopause, 0-<8, 8-<16, and 16-28 yr after menopause. Data are presented as means with 95% confidence intervals. The annual BMC changes in the 4 periods were -1.4% (-0.1, -2.6), -1.1% (-0.9, -1.4), -1.2% (-0.9, -1.6), and -1.1% (-0.8, -1.4) and the annual increase in bone width 0.4% (-1.2, 1.9), 0.7% (0.5, 0.9), 0.1% (-0.2, 0.4), and 0.1% (-0.2, 0.4). BMC loss was similar in all periods, whereas the increase in bone width was higher in the first postmenopausal period than in the second (p = 0.003) and the third (p = 0.01) postmenopausal periods. Menopause is followed by a transient increase in forearm bone size that will influence the by aBMD estimated cortical loss in bone minerals.
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| 9. |
- Lekamwasam, Sarath, et al.
(författare)
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Effect of hip flexion on the measurement of spinal bone mineral density in the Norland Eclipse XR
- 2005
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Ingår i: Journal of Clinical Densitometry. - 1094-6950. ; 8:2, s. 183-186
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Tidskriftsartikel (refereegranskat)abstract
- It is recommended that the hip joints be flexed to 90 degrees during dual-energy X-ray absorptiometry scanning of the lumbar spine in the anteroposterior projection; however, some patients are unable to maintain this position because of the presence of degenerative changes in lower limb joints. This study examines the effect of a lesser degree of hip flexion on the lumbar spine bone mineral density (BMD) measurement and its interpretation. Fifty women were scanned on the Norland Eclipse XR, initially in the standard position with the hips flexed to 90 degrees and then in the adjusted position after allowing for some degree of hip extension to keep them comfortable (hip flexion of 60 degrees -70 degrees ).Higher bone mineral content (BMC), surface area, and BMD values were seen in the standard position compared to the adjusted position, but none of the differences was statistically significant. There were strong correlations for BMC,surface area, and BMD measured in the two positions. In the standard position, 26 women were found to have osteoporosis and 18 had osteopenia. In the adjusted position, osteoporosis was noted in 27 women, and 18 had osteopenia.Four women showed a reduction, whereas 12 women showed an increase in BMD in excess of the least significant change at the 95% confidence level, defined as 2.77 times the precision error (0.008 g/cm(2) x 2.77 = 0.120 g/cm(2)). Our study demonstrates that a lesser degree of hip flexion in women who find it difficult to maintain the recommended 90 degrees hip flexion during the lumbar spine BMD measurement would not affect the patient classification based on T-scores recommended by the World Health Organization; however, variation in hip flexion can be a major confounding factor when interpreting a change in BMD over time.
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| 10. |
- Lenora, Janaka, et al.
(författare)
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Effect of Precision on Longitudinal Follow-Up of Bone Mineral Density Measurements in Elderly Women and Men.
- 2010
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Ingår i: Journal of Clinical Densitometry. - : Elsevier BV. - 1094-6950. ; 13:4, s. 407-412
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Tidskriftsartikel (refereegranskat)abstract
- Precision error of dual-energy X-ray absorptiometry exceeds the expected annual rate of bone loss in the elderly. The capacity to detect changes in areal bone mineral density (aBMD; g/cm(2)) over a 5-yr period was assessed. Six hundred ninety-one women, 75.2 (0.1)yr, from the Malmö OPRA-study, were measured using Lunar DPX-L (GE Lunar, Madison, WI), and 211 men, 74.7 (3.2)yr, from the Malmö Mr Os-study, were measured using Lunar Prodigy (GE Lunar) with follow-up 5yr later. Precision error was determined with 30 degrees of freedom. Least significant change (LSC, i.e., 2.77xprecision error) was calculated. Women's precision errors (g/cm(2)) for DPX-L were 0.028 (total hip [TH]) and 0.016 (lumbar spine [LS]), and for Prodigy, they were 0.009 (TH) and 0.039 (LS). In men, corresponding results for Prodigy were 0.014 and 0.031. In women, 41% and in men, 39% had aBMD changes exceeding the LSC at TH. Follow-up intervals (i.e., LSC/median rate of aBMD change) for both women and men were 8yr (TH) and 13yr (LS). Based on Prodigy precision data, follow-up intervals for women were 3 and 32yr at TH and LS. In summary, several years were needed to detect change. Only when a high rate of bone loss is suspected, a short follow-up time is possible, in elderly persons.
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