| 1. |
- Karlsson, Magnus, et al.
(författare)
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An Increase in Forearm Cortical Bone Size After Menopause May Influence the Estimated Bone Mineral Loss-A 28-Year Prospective Observational Study.
- 2016
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Ingår i: Journal of Clinical Densitometry. - : Elsevier BV. - 1094-6950. ; 19:2, s. 174-179
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Tidskriftsartikel (refereegranskat)abstract
- Areal bone mineral density (aBMD) is the most common estimate of bone mass, incorporated in the World Health Organization definition of osteoporosis. However, aBMD depends on not only the amount of mineral but also the bone size. The estimated postmenopausal decline in aBMD could because of this be influenced by changes in bone size.We measured bone mineral content (BMC; mg), aBMD (mg/cm(2)), and bone width (mm) by single-photon absorptiometry at the cortical site of the forearm in a population-based sample of 105 Caucasian women. We conducted 12 measurements during a 28-yr period from mean 5 yr (range: 2-9) before menopause to mean 24 yr (range: 18-28) after menopause. We calculated individual slopes for changes in the periods before menopause, 0-<8, 8-<16, and 16-28 yr after menopause. Data are presented as means with 95% confidence intervals. The annual BMC changes in the 4 periods were -1.4% (-0.1, -2.6), -1.1% (-0.9, -1.4), -1.2% (-0.9, -1.6), and -1.1% (-0.8, -1.4) and the annual increase in bone width 0.4% (-1.2, 1.9), 0.7% (0.5, 0.9), 0.1% (-0.2, 0.4), and 0.1% (-0.2, 0.4). BMC loss was similar in all periods, whereas the increase in bone width was higher in the first postmenopausal period than in the second (p = 0.003) and the third (p = 0.01) postmenopausal periods. Menopause is followed by a transient increase in forearm bone size that will influence the by aBMD estimated cortical loss in bone minerals.
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| 2. |
- Lindgren, Erik, et al.
(författare)
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Bone Traits Seem to Develop Also During the Third Decade in Life-Normative Cross-Sectional Data on 1083 Men Aged 18-28 Years
- 2017
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Ingår i: Journal of clinical densitometry. - : Elsevier BV. - 1094-6950. ; 20:1, s. 32-43
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Tidskriftsartikel (refereegranskat)abstract
- By identifying individuals with low peak bone mass (PBM) at young age, early targeted interventions to reduce future fracture risk could be possible. Peripheral quantitative computed tomography (pQCT) is in many ways superior to the gold standard dual-energy X-ray absorptiometry (DXA), as cortical and trabecular compartments as well as the volumetric density and bone structure can be examined separately. Because each of these traits contributes independently to bone strength, it is probable that pQCT provides an even better fracture risk estimation than DXA. Currently, the clinical applications of pQCT are limited partly because comprehensive normative pQCT data, especially in young men, are not readily available. We therefore set up a study in young men with the following objectives: (1) to identify peak ages in pQCT bone traits with special reference to PBM and peak bone strength; and (2) to provide normative pQCT data. We measured volumetric bone mineral density and structural parameters at ultradistal (trabecular bone) and diaphyseal radius and tibia (cortical bone) by pQCT scans (Stratec XCT2000(R); Stratec Medizintechnik GmbH, Pforzheim, Germany) in a population-based age-stratified sample of 1083 men aged 18-28 yr residing in greater Malmo, Sweden. Group differences in 1-yr classes were evaluated by analysis of variance. We found similar bone traits in age groups at ultradistal sites whereas most bone traits at diaphyseal sites were higher with higher ages, however with different increment patterns depending on the specific trait. In Swedish young adult men, we found that different bone traits continued to change after age 18, but at different rates, indicating that peak areal bone mineral density (as measured by DXA) and peak bone strength may be reached at different ages.
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