SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:1355 6037 OR L773:1468 201X ;hsvcat:3"

Sökning: L773:1355 6037 OR L773:1468 201X > Medicin och hälsovetenskap

  • Resultat 1-10 av 1570
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Skrtic, Stanko, 1970, et al. (författare)
  • Contemporary risk estimates of three HbA(1c) variables in relation to heart failure following diagnosis of type 2 diabetes
  • 2017
  • Ingår i: Heart. - : BMJ. - 1355-6037 .- 1468-201X. ; 103:5, s. 355-360
  • Tidskriftsartikel (refereegranskat)abstract
    • Background We evaluated the association between glycaemic control and the risk of heart failure (HF) in a contemporary cohort of persons followed after diagnosis of type 2 diabetes (T2D). Methods and results Persons with T2D diagnosed between 1998 and 2012 were retrieved from the Clinical Practice Research Data Link in the UK and followed from diagnosis until the event of HF, mortality, drop out from the database due to any other reason, or the end of the study on 1 July 2015. The association between each of three different haemoglobin A(1C) (HbA1c) metrics and HF was estimated using adjusted proportional hazard models. In the overall cohort (n= 94 332), the increased risk for HF per 1% (10 mmol/mol) increase in HbA(1c) was 1.15 (95% CI 1.13 to 1.18) for updated mean HbA(1c), and 1.06 (1.04 to 1.07) and 1.06 (1.04 to 1.08) for baseline HbA(1c) and updated latest HbA(1c), respectively. When categorised, the hazard risk (HR) for the updated mean HbA(1c) in relation to HF became higher than for baseline and updated latest HbA(1c) above HbA(1c) levels of 9%, but did not differ at lower HbA(1c) levels. The updated latest variable showed an increased risk for HbA(1c)
  •  
2.
  • Johansson, Madeleine, et al. (författare)
  • Cardiovascular biomarkers predict fragility fractures in older adults
  • 2019
  • Ingår i: Heart. - : BMJ. - 1355-6037 .- 1468-201X. ; 105:6, s. 449-454
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective To assess the role of four biomarkers of neuroendocrine activation and endothelial dysfunction in the longitudinal prediction of fragility fractures. Methods We analysed a population-based prospective cohort of 5415 community-dwelling individuals (mean age, 68.9±6.2 years) enrolled in the Malmö Preventive Project followed during 8.1±2.9 years, and investigated the longitudinal association between C-terminal pro-arginine vasopressin (CT-proAVP), C-terminal endothelin-1 precursor fragment (CT-proET-1), the mid-regional fragments of pro-adrenomedullin (MR-proADM) and pro-atrial natriuretic peptide (MR-proANP), and incident vertebral, pelvic and extremity fractures. Results Overall, 1030 (19.0%) individuals suffered vertebral, pelvic or extremity fracture. They were older (70.7±5.8 vs 68.4±6.3 years), more likely women (46.9% vs 26.3%), had lower body mass index and diastolic blood pressure, were more often on antihypertensive treatment (44.1% vs 38.4%) and had more frequently history of fracture (16.3% vs 8.1%). Higher levels of MR-proADM (adjusted HR (aHR) per 1 SD: 1.51, 95% CI 1.01 to 2.28, p<0.001) and MR-proANP (aHR: 1.23, 95% CI 1.05 to 1.45, p<0.001) were independently associated with increased risk of any fracture. The fracture risk increased linearly across MR-proANP quartiles. Individuals who were in the top quartile of all four biomarkers had a significant higher risk of fracture at any site (aHR: 2.32, 95% CI 1.86 to 2.91), vertebral fracture (aHR: 3.16, 95% CI 1.97 to 5.07) and femoral fracture (aHR: 2.35, 95% CI 1.64 to 3.36). Conclusions Elevated levels of MR-proADM and MR-proANP independently predict fragility fractures in older adults. In subjects with top quartile levels of all four biomarkers there is a twofold to threefold increase in risk of vertebral and femoral fractures.
  •  
3.
  • Janzon, Magnus, et al. (författare)
  • Health economic analysis of ticagrelor in patients with acute coronary syndromes intended for non-invasive therapy
  • 2015
  • Ingår i: Heart. - : BMJ. - 1355-6037 .- 1468-201X. ; 101:2, s. 119-125
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective To investigate the cost effectiveness of ticagrelor versus clopidogrel in patients with acute coronary syndromes (ACS) in the Platelet Inhibition and Patient Outcomes (PLATO) study who were scheduled for non-invasive management. Methods A previously developed cost effectiveness model was used to estimate long-term costs and outcomes for patients scheduled for non-invasive management. Healthcare costs, event rates and health-related quality of life under treatment with either ticagrelor or clopidogrel over 12 months were estimated from the PLATO study. Long-term costs and health outcomes were estimated based on data from PLATO and published literature sources. To investigate the importance of different healthcare cost structures and life expectancy for the results, the analysis was carried out from the perspectives of the Swedish, UK, German and Brazilian public healthcare systems. Results Ticagrelor was associated with lifetime quality-adjusted life-year (QALY) gains of 0.17 in Sweden, 0.16 in the UK, 0.17 in Germany and 0.13 in Brazil compared with generic clopidogrel, with increased healthcare costs of (sic)467, (sic)551, (sic)739 and (sic)574, respectively. The cost per QALY gained with ticagrelor was (sic)2747, (sic)3395, (sic)4419 and (sic)4471 from a Swedish, UK, German and Brazilian public healthcare system perspective, respectively. Probabilistic sensitivity analyses indicated that the cost per QALY gained with ticagrelor was below conventional threshold values of cost effectiveness with a high probability. Conclusions Treatment of patients with ACS scheduled for 12 months' non-invasive management with ticagrelor is associated with a cost per QALY gained below conventional threshold values of cost effectiveness compared with generic clopidogrel.
  •  
4.
  • Lind, Lars, et al. (författare)
  • Discovery of new biomarkers for atrial fibrillation using a custom-made proteomics chip.
  • 2017
  • Ingår i: Heart. - : BMJ. - 1355-6037 .- 1468-201X. ; 103:5, s. 377-382
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Apart from several established clinical risk factors for atrial fibrillation (AF), a number of biomarkers have also been identified as potential risk factors for AF. None of these have so far been adopted in clinical practice.OBJECTIVE: To use a novel custom-made proteomics chip to discover new prognostic biomarkers for AF risk.METHODS: In two independent community-based cohorts (Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (978 participants without AF, mean age 70.1 years, 50% women, median follow-up 10.0 years) and Uppsala Longitudinal Study of Adult Men (ULSAM) (n=725, mean age 77.5 years, median follow-up 7.9 years)), ninety-two plasma proteins were assessed at baseline by a proximity extension assay (PEA) chip. Of those, 85 proteins showed a call rate >70% in both cohorts.RESULTS: Thirteen proteins were related to incident AF in PIVUS (148 events) using a false discovery rate of 5%. Of those, five were replicated in ULSAM at nominal multivariable p value (123 events, N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), fibroblast growth factor 23 (FGF-23), fatty acid-binding protein 4 (FABP4), growth differentiation factor 15 (GDF-15) and interleukin-6 (IL-6)). Of those, NT-pro-BNP and FGF-23 were also associated with AF after adjusting for established AF risk factors. In a prespecified secondary analysis pooling the two data sets, T-cell immunoglobulin and mucin domain 1 (TIM-1) and adrenomedullin (AM) were also significantly related to incident AF in addition to the aforementioned five proteins (Bonferroni-adjustment). The addition of NT-pro-BNP to a model with established risk factors increased the C-statistic from 0.605 to 0.676 (p<0.0001).CONCLUSIONS: Using a novel proteomics approach, we confirmed the previously reported association between NT-pro-BNP, FGF-23, GDF-15 and incident AF, and also discovered four proteins (FABP4, IL-6, TIM-1 and AM) that could be of importance in the development of AF.
  •  
5.
  • Berti, Dana, et al. (författare)
  • Prevalence and antithrombotic management of atrial fibrillation in hospitalised patients.
  • 2015
  • Ingår i: Heart (British Cardiac Society). - : BMJ. - 1468-201X .- 1355-6037. ; 101:11, s. 884-893
  • Tidskriftsartikel (refereegranskat)abstract
    • The objective of this study was to determine the prevalence of atrial fibrillation (AF) in a tertiary care centre, to describe the comorbidity profile of hospitalised patients with AF, and to evaluate the appropriateness of their maintenance antithrombotic management.
  •  
6.
  • Jonsson, M., et al. (författare)
  • Survival after out-of-hospital cardiac arrest is associated with area-level socioeconomic status
  • 2019
  • Ingår i: Heart. - : BMJ. - 1355-6037 .- 1468-201X. ; 105:8, s. 632-638
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective Out-of-hospital cardiac arrest (OHCA) is a major cause of death in the Western world. In this study we aimed to investigate the relationship between area-level socioeconomic status (SES) and 30-day survival after OHCA. We hypothesised that high SES at an area level is associated with an improved chance of 30-day survival. Methods Patients with OHCA in Stockholm County between 1 January 2006 and 31 December 2015 were analysed retrospectively. To quantify area-level SES, we linked the patient's home address to 250 x 250/1000 x 1000 meter grids with aggregated information about income and education. We constructed multivariable logistic regression models in which area-level SES measures were adjusted for age, sex, emergency medical services response time, witnessed status, initial rhythm, aetiology, location and year of cardiac arrest. Results We included 7431 OHCAs. There was significantly greater 30-day survival (p=0.003) in areas with a high proportion of university-educated people. No statistically significant association was seen between median disposable income and 30-day survival. The adjusted OR for 30-day survival among patients in the highest educational quintile was 1.70 (95% CI 1.15 to 2.51) compared with patients in the lowest educational quintile. We found no significant interaction for sex. Positive trend with increasing area-level education was seen in both men and women but the trend was only statistically significant among men (p=0.012) Conclusions Survival to 30 days after OHCA is positively associated with the average educational level of the residential area. Area-level income does not independently predict 30-day survival after OHCA.
  •  
7.
  • Persson, Anita, 1971, et al. (författare)
  • Long-term prognostic value of mitral regurgitation in acute coronary syndromes.
  • 2010
  • Ingår i: Heart (British Cardiac Society). - : BMJ. - 1468-201X .- 1355-6037. ; 96:22, s. 1803-8
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: To determine the additional prognostic value of mitral regurgitation (MR) over B-type natriuretic peptide (BNP), left ventricular ejection fraction (LVEF) and clinical characteristics in patients with acute coronary syndromes (ACS). DESIGN: Long-term follow-up in a prospective ACS cohort with Doppler-assessed MR, echocardiographically-determined LVEF and plasma BNP levels by ELISA. SETTING: Single-centre university hospital. PATIENTS: 725 patients with ACS. MAIN OUTCOME MEASURES: Death and readmission for congestive heart failure. RESULTS: During a median follow-up of 98 months, 235 patients (32%) died. Significant MR (grade >1 of 4) was found in 90 patients (12%). In a multivariate model including MR grade >1, LVEF <0.40 and BNP >373 pg/ml (75th percentile), MR was significantly associated with long-term mortality (HR 2.28, 95% CI 1.67 to 3.12; p<0.0001). When also adjusting for conventional risk factors, MR remained significantly associated with mortality (HR 1.53, 95% CI 1.06 to 2.19; p=0.02), as well as with congestive heart failure (HR 2.08, 95% CI 1.29 to 3.35; p=0.003). CONCLUSIONS: MR is common in patients with ACS, provides independent risk information and should be taken into account in the evaluation of the long-term prognosis.
  •  
8.
  • Berglund, Elisabeth, et al. (författare)
  • High incidence of infective endocarditis in adults with congenital ventricular septal defect
  • 2016
  • Ingår i: Heart. - : BMJ. - 1355-6037 .- 1468-201X. ; 102:22, s. 1835-1839
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: Ventricular septal defects (VSDs), if haemodynamically important, are closed whereas small shunts are left without intervention. The long-term prognosis in congenital VSD is good but patients are still at risk for long-term complications. The aim of this study was to clarify the incidence of infective endocarditis (IE) in adults with VSD. METHODS: The Swedish registry for congenital heart disease (SWEDCON) was searched for adults with VSD. 779 patients were identified, 531 with small shunts and 248 who had the VSD previously closed. The National Patient Register was then searched for hospitalisations due to IE in adults during a 10-year period. RESULTS: Sixteen (2%) patients were treated for IE, 6 men and 10 women, with a mean age of 46.3+/-12.2 years. The incidence of IE was 1.7-2.7/1000 years in patients without previous intervention, 20-30 times the risk in the general population. Thirteen had small shunts without previous intervention. There was no mortality in these 13 cases. Two patients had undergone repair of their VSD and also aortic valve replacement before the episode of endocarditis and a third patient with repaired VSD had a bicuspid aortic valve, all of these three patients needed reoperation because of their IE and one patient died. No patient with isolated and operated VSD was diagnosed with IE. CONCLUSIONS: A small unoperated VSD in adults carries a substantially increased risk of IE but is associated with a low risk of mortality.
  •  
9.
  • Grzymala-Lubanski, Bartosz, et al. (författare)
  • Warfarin treatment quality and prognosis in patients with mechanical heart valve prosthesis.
  • 2017
  • Ingår i: Heart (British Cardiac Society). - : BMJ. - 1468-201X .- 1355-6037. ; 103:3
  • Tidskriftsartikel (refereegranskat)abstract
    • To study the impact of time in therapeutic range (TTR) and international normalised ratio (INR) variability on the risk of thromboembolic events, major bleeding complications and death after mechanical heart valve (MHV) implantation. Additionally, the importance of different target INR levels was elucidated.
  •  
10.
  • Hansson, Emma C., 1985, et al. (författare)
  • Prevalence, indications and appropriateness of antiplatelet therapy in patients operated for acute aortic dissection: associations with bleeding complications and mortality.
  • 2013
  • Ingår i: Heart (British Cardiac Society). - : BMJ. - 1468-201X .- 1355-6037. ; 99:2, s. 116-121
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To assess the prevalence, indications and appropriateness of antiplatelet therapy in patients operated for acute aortic dissection and its associations with bleeding complications and mortality. DESIGN: A retrospective single-centre study comparing patients with and without ongoing antiplatelet therapy. SETTING: University Hospital in Western Sweden. PATIENTS: 133 consecutive patients operated during 2007-2011. INTERVENTIONS: All patients were operated for acute aortic dissection type A. MAIN OUTCOME MEASURES: Indication and appropriateness of antiplatelet therapy; perioperative bleeding complications, transfusions and mortality. RESULTS: 43 of 133 patients (32%) had ongoing platelet inhibition at the time of surgery, 19 (14%) with acetylsalicylic acid (ASA) alone and 24 (18%) with ASA and clopidogrel. Unspecific chest pain and ST depression were the most common indications (42% and 23%, respectively). 2.3% had ST elevation and 12% had elevated biomarkers for myocardial injury. Only 29% of the patients with dual antiplatelet therapy had appropriate treatment according to current guidelines. Patients with ongoing platelet inhibition had significantly larger intraoperative (1800 (IQR 950-4250) vs 800 ml (500-2500), p=0.010) and postoperative bleeding volumes (800 (420-1605) vs 500 ml (390-1070), p=0.037). 30-day mortality in patients on dual antiplatelet therapy was 30.4% compared with 13.0% in patients with no or single antiplatelet therapy (p=0.038). CONCLUSIONS: The indication for immediate antiplatelet therapy in patients later operated for acute aortic dissection was weak or absent in the majority of cases. Patients with ongoing platelet inhibition had more bleeding complications. Dual antiplatelet therapy was associated with increased early mortality.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 1570
Typ av publikation
tidskriftsartikel (1475)
konferensbidrag (47)
forskningsöversikt (47)
recension (1)
Typ av innehåll
refereegranskat (1326)
övrigt vetenskapligt/konstnärligt (244)
Författare/redaktör
Rantapää-Dahlqvist, ... (38)
Rönnelid, Johan (37)
Bremander, Ann, 1957 ... (34)
Rönnblom, Lars (31)
Bergman, Stefan, 195 ... (31)
Geborek, Pierre (30)
visa fler...
Edvinsson, Lars (27)
Zetterberg, Henrik, ... (24)
Nordmark, Gunnel (24)
Hesselstrand, Roger (23)
Turesson, Carl (21)
Halfvarson, Jonas, 1 ... (21)
Klareskog, Lars (21)
Jacobsson, Lennart T ... (21)
Lohmander, Stefan (21)
Sturfelt, Gunnar (20)
Haglund, Emma, 1970- (19)
Englund, Martin (18)
Gunnarsson, Iva (16)
Theander, Elke (16)
Larsson, Ingrid, 196 ... (16)
KLARESKOG, L (15)
Nilsson, Jan Åke (15)
Svenungsson, Elisabe ... (15)
Simrén, Magnus, 1966 (15)
Nilsson, Peter (14)
Eloranta, Maija-Leen ... (14)
Blennow, Kaj, 1958 (13)
Ludvigsson, Jonas F. ... (13)
van Vollenhoven, Ron ... (13)
Janson, Christer (12)
Isenberg, D (12)
Jernberg, Tomas (12)
Engström, Gunnar (11)
Giwercman, Aleksande ... (11)
Rosengren, Annika, 1 ... (11)
Forslind, Kristina (11)
Holmdahl, Rikard (11)
Bengtsson, Anders (10)
Westman, Kerstin (10)
Sundquist, Kristina (10)
Jönsen, Andreas (10)
Ramos-Casals, M. (10)
Wolk, Alicja (10)
Agréus, Lars (10)
Persson, Carl (10)
Sundquist, Jan (10)
Huizinga, T W J (10)
Wallentin, Lars (10)
Eberhardt, Kerstin (10)
visa färre...
Lärosäte
Lunds universitet (586)
Karolinska Institutet (376)
Uppsala universitet (295)
Göteborgs universitet (246)
Umeå universitet (231)
Örebro universitet (102)
visa fler...
Linköpings universitet (69)
Högskolan i Halmstad (66)
Stockholms universitet (41)
Kungliga Tekniska Högskolan (27)
Jönköping University (26)
Mälardalens universitet (25)
Karlstads universitet (12)
Högskolan i Skövde (9)
Högskolan Dalarna (9)
Malmö universitet (8)
Linnéuniversitetet (8)
Luleå tekniska universitet (7)
Chalmers tekniska högskola (7)
Högskolan Kristianstad (6)
Södertörns högskola (6)
Gymnastik- och idrottshögskolan (6)
Högskolan i Gävle (5)
Sophiahemmet Högskola (5)
Röda Korsets Högskola (5)
Högskolan i Borås (4)
Sveriges Lantbruksuniversitet (4)
Marie Cederschiöld högskola (4)
Högskolan Väst (3)
Blekinge Tekniska Högskola (3)
Mittuniversitetet (2)
Handelshögskolan i Stockholm (1)
visa färre...
Språk
Engelska (1569)
Odefinierat språk (1)
Forskningsämne (UKÄ/SCB)
Samhällsvetenskap (58)
Naturvetenskap (13)
Teknik (7)
Humaniora (6)
Lantbruksvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy