| 1. |
- Bermejo Gómez, Antonio, et al.
(author)
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Efficient DBU accelerated synthesis of F-18-labelled trifluoroacetamides
- 2016
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In: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1359-7345 .- 1364-548X. ; 52:97, s. 13963-13966
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Journal article (peer-reviewed)abstract
- Nucleophilic F-18-fluorination of bromodifluoromethyl derivatives was performed using [F-18] Bu4NF in the presence of DBU(1,8-diazabicyclo[5.4.0]undec-7-ene). This novel procedure provided a diverse set of [F-18] trifluoroacetamides in good to excellent radiochemical conversions. A mechanism where DBU acts as organomediator in this transformation is proposed.
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| 2. |
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| 3. |
- Cortés González, Miguel A., et al.
(author)
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Rhodium-mediated 18F-oxyfluorination ofdiazoketones using a fluorine-18-containing hypervalent iodine reagent
- 2019
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In: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1359-7345 .- 1364-548X. ; 55:89, s. 13358-13361
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Journal article (peer-reviewed)abstract
- Geminal 18F-oxyfluorination of diazoketones was performed in the presence of rhodium mediators. The reactions were performed using a hypervalent iodine-based [18F]fluoro-benziodoxole reagent. By this methodology various α-[18F]fluoro ethers were obtained in high radiochemical yield (up to 98%) and molar activity (216 GBq μmol-1).
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| 4. |
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| 5. |
- Ilchenko, Nadia O., et al.
(author)
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Copper-mediated C-H trifluoromethylation of quinones
- 2013
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In: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1359-7345 .- 1364-548X. ; 49:59, s. 6614-6616
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Journal article (peer-reviewed)abstract
- Quinones undergo copper-mediated C-H trifluoromethylation reactions using a hypervalent iodine reagent. The reactions have a broad synthetic scope involving naphtho, alkyl, chloro and methoxy quinones.
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| 6. |
- Jonker, Sybrand J. T., et al.
(author)
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Catalytic asymmetric propargyl- and allylboration of hydrazonoesters : a metal-free approach to sterically encumbered chiral alpha-amino acid derivatives
- 2018
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In: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1359-7345 .- 1364-548X. ; 54:91, s. 12852-12855
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Journal article (peer-reviewed)abstract
- A new asymmetric catalytic propargyl- and allylboration of hydrazonoesters is reported. The reactions utilize allenyl- and allylboronic acids in the presence of the inexpensive parent BINOL catalyst. The reactions can be performed under mild conditions (0 degrees C) without any metal catalyst or other additives affording sterically encumbered chiral -amino acids. This is the first metal-free method for the asymmetric propargyl- and allylboration of hydrazonoesters.
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| 7. |
- Meyer, Denise N., et al.
(author)
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Base-catalysed F-18-labelling of trifluoromethyl ketones. Application to the synthesis of F-18-labelled neutrophil elastase inhibitors
- 2021
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In: Chemical Communications. - : Royal Society of Chemistry. - 1359-7345 .- 1364-548X. ; 57:68, s. 8476-8479
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Journal article (peer-reviewed)abstract
- A new method for the fluorine-18 labelling of trifluoromethyl ketones has been developed. This method is based on the conversion of a-COCF3 functional group to a difluoro enol silyl ether followed by halogenation and fluorine-18 labelling. The utility of this new method was demonstrated by the synthesis of fluorine-18 labelled neutrophil elastase inhibitors, which are potentially useful for detection of inflammatory disorders.
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| 9. |
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