Sökning: L773:1386 341X
> Clemmons David >
Development of ACRO...
Development of ACRODAT®, a new software medical device to assess disease activity in patients with acromegaly
-
- van der Lely, Aart Jan (författare)
- Erasmus University Medical Center
-
- Gomez, Roy (författare)
- Pfizer Inc. US
-
- Pleil, Andreas (författare)
- Pfizer Inc. US
-
visa fler...
-
- Badia, Xavier (författare)
- University of Barcelona
-
- Brue, Thierry (författare)
- Aix-Marseille University
-
- Buchfelder, Michael (författare)
- University Hospital Erlangen
-
- Burman, Pia (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital
-
- Clemmons, David (författare)
- UNC Health Care
-
- Ghigo, Ezio (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
-
- Jørgensen, Jens Otto Lunde (författare)
- Aarhus University
-
- Luger, Anton (författare)
- Vienna General Hospital / University Hospital Vienna
-
- van der Lans-Bussemaker, Joli (författare)
- Pfizer Inc. US
-
- Webb, Susan M. (författare)
- Biomedical Network on Rare Diseases (CIBERER)
-
- Strasburger, Christian J (författare)
- Charité - University Medicine Berlin
-
visa färre...
-
Erasmus University Medical Center Pfizer Inc US (creator_code:org_t)
- 2017-09-08
- 2017
- Engelska.
-
Ingår i: Pituitary. - : Springer Science and Business Media LLC. - 1386-341X .- 1573-7403. ; 20:6, s. 692-701
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://link.springe...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Purpose: Despite availability of multimodal treatment options for acromegaly, achievement of long-term disease control is suboptimal in a significant number of patients. Furthermore, disease control as defined by biochemical normalization may not always show concordance with disease-related symptoms or patient’s perceived quality of life. We developed and validated a tool to measure disease activity in acromegaly to support decision-making in clinical practice. Methods: An international expert panel (n = 10) convened to define the most critical indicators of disease activity. Patient scenarios were constructed based on these chosen parameters. Subsequently, a panel of 21 renowned endocrinologists at pituitary centers (Europe and Canada) categorized each scenario as stable, mild, or significant disease activity in an online validation study. Results: From expert opinion, five parameters emerged as the best overall indicators to evaluate disease activity: insulin-like growth factor I (IGF-I) level, tumor status, presence of comorbidities (cardiovascular disease, diabetes, sleep apnea), symptoms, and health-related quality of life. In the validation study, IGF-I and tumor status became the predominant parameters selected for classification of patients with moderate or severe disease activity. If IGF-I level was ≤1.2x upper limit of normal and tumor size not significantly increased, the remaining three parameters contributed to the decision in a compensatory manner. Conclusion: The validation study underlined IGF-I and tumor status for routine clinical decision-making, whereas patient-oriented outcome measures received less medical attention. An Acromegaly Disease Activity Tool (ACRODAT) is in development that might assist clinicians towards a more holistic approach to patient management in acromegaly.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- ACRODAT
- Acromegaly
- AcroQoL
- Patient-reported outcomes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
van der Lely, Aa ...
-
Gomez, Roy
-
Pleil, Andreas
-
Badia, Xavier
-
Brue, Thierry
-
Buchfelder, Mich ...
-
visa fler...
-
Burman, Pia
-
Clemmons, David
-
Ghigo, Ezio
-
Jørgensen, Jens ...
-
Luger, Anton
-
van der Lans-Bus ...
-
Webb, Susan M.
-
Strasburger, Chr ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Pituitary
- Av lärosätet
-
Lunds universitet