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The Use of Central ...
The Use of Central Nervous System Active Drugs During Pregnancy
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- Källén, Bengt (author)
- Lund University,Lunds universitet,Tornbladinstitutet,Forskargrupper vid Lunds universitet,Tornblad Institute,Lund University Research Groups,Tornblad Institute, Lund Univeraity, Sweden
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- Borg, Natalia (author)
- Department of Statistics, Monitoring and Analyses, National Board of Health and Welfare, Sweden
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- Reis, Margareta (author)
- Lund University,Lunds universitet,Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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(creator_code:org_t)
- 2013-10-10
- 2013
- English.
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In: Pharmaceuticals. - : MDPI AG. - 1424-8247. ; 6:10, s. 1221-1286
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Abstract
Subject headings
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- CNS-active drugs are used relatively often during pregnancy. Use during early pregnancy may increase the risk of a congenital malformation; use during the later part of pregnancy may be associated with preterm birth, intrauterine growth disturbances and neonatal morbidity. There is also a possibility that drug exposure can affect brain development with long-term neuropsychological harm as a result. This paper summarizes the literature on such drugs used during pregnancy: opioids, anticonvulsants, drugs used for Parkinson’s disease, neuroleptics, sedatives and hypnotics, antidepressants, psychostimulants, and some other CNS-active drugs. In addition to an overview of the literature, data from the Swedish Medical Birth Register (1996–2011) are presented. The exposure data are either based on midwife interviews towards the end of the first trimester or on linkage with a prescribed drug register. An association between malformations and maternal use of anticonvulsants and notably valproic acid is well known from the literature and also demonstrated in the present study. Some other associations between drug exposure and outcome were found.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- CNS active drugs; opioids; sedatives; hypnotics; antidepressants; psychostimulants; congenital malformations; neonatal morbidity
Publication and Content Type
- ref (subject category)
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