| 1. |
- Wang, Chao, et al.
(författare)
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The role of pro-inflammatory S100A9 in Alzheimer's disease amyloid-neuroinflammatory cascade
- 2014
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Ingår i: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 0001-6322 .- 1432-0533. ; 127:4, s. 507-522
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Tidskriftsartikel (refereegranskat)abstract
- Pro-inflammatory S100A9 protein is increasingly recognized as an important contributor to inflammation-related neurodegeneration. Here, we provide insights into S100A9 specific mechanisms of action in Alzheimer's disease (AD). Due to its inherent amyloidogenicity S100A9 contributes to amyloid plaque formation together with A beta. In traumatic brain injury (TBI) S100A9 itself rapidly forms amyloid plaques, which were reactive with oligomer-specific antibodies, but not with A beta and amyloid fibrillar antibodies. They may serve as precursor-plaques for AD, implicating TBI as an AD risk factor. S100A9 was observed in some hippocampal and cortical neurons in TBI, AD and non-demented aging. In vitro S100A9 forms neurotoxic linear and annular amyloids resembling A beta protofilaments. S100A9 amyloid cytotoxicity and native S100A9 pro-inflammatory signaling can be mitigated by its co-aggregation with A beta, which results in a variety of micron-scale amyloid complexes. NMR and molecular docking demonstrated transient interactions between native S100A9 and A beta. Thus, abundantly present in AD brain pro-inflammatory S100A9, possessing also intrinsic amyloidogenic properties and ability to modulate A beta aggregation, can serve as a link between the AD amyloid and neuroinflammatory cascades and as a prospective therapeutic target.
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| 2. |
- Patacchini, Eleonora, et al.
(författare)
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Unexplored dimensions of discrimination in Europe : homosexuality and physical appearance
- 2015
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Ingår i: Journal of Population Economics. - : Springer Science and Business Media LLC. - 0933-1433 .- 1432-1475. ; 28:4, s. 1045-1073
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Tidskriftsartikel (refereegranskat)abstract
- We study labor-market discrimination of individuals with specific characteristics in Italy. We conduct a field experiment in two Italian cities: Rome and Milan, by sending fake CVs to real ads. We find that there is a strong penalty for homosexuals, i.e., about 30 % less chance to be called back compared to a heterosexual male and even more so if they are highly skilled. On the other hand, we find no penalty for homosexual females. We also find a beauty premium for females only but this premium is much lower when the pretty woman is skilled.
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