| 1. |
- Abrahamson, Magnus, et al.
(författare)
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The human cystatin C gene (CST3), mutated in hereditary cystatin C amyloid angiopathy, is located on chromosome 20
- 1989
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Ingår i: Human Genetics. - 1432-1203. ; 82:3, s. 223-226
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Tidskriftsartikel (refereegranskat)abstract
- Hereditary cystatin C amyloid angiopathy has recently been shown to be caused by a point mutation in the cystatin C gene. To determine the chromosomal localization of the gene, 20 human-rodent somatic cell hybrids and a fulllength cystatin C cDNA probe were used. Southern blot analysis of BamHI digested cell hybrid DNA revealed that the probe recognizes a 10.6 kb human specific fragment and that this fragment cosegregates with human chromosome 20. Therefore, the human cystatin C gene (CST3) was assigned to chromosome 20.
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| 2. |
- Agardh, Carl-David, et al.
(författare)
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Hypoglycemic brain injury. I. Metabolic and light microscopic findings in rat cerebral cortex during profound insulin-induced hypoglycemia and in the recovery period following glucose administration
- 1980
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Ingår i: Acta Neuropathologica. - 1432-0533. ; 50:1, s. 31-41
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Tidskriftsartikel (refereegranskat)abstract
- Profound hypoglycemia causing the disappearance of spontaneous EEG activity was induced by insulin in rats. For analysis of cerebral cortical concentrations of labile phosphates, glycolytic metabolites and amino acids, the brain was frozen in situ. For microscopic analysis of the corresponding cerebral cortical areas the brain was fixed by perfusion. Hypoglycemia with an isoelectric EEG for 30 and 60 min caused severe perturbation of the cerebral energy metabolites. After both 30 and 60 min of isoelectric EEG, two microscopically different types of nerve cell injury were seen. Type I injury was characterized by angulated, darkly stained neurons with perineuronal vacuolation, mainly affecting small neurons in cortical layer 3. Type II injured neurons, mainly larger ones in layers 5–6, were slightly swollen with vacuolation or clearing (depending on the histotechnique used) of the peripheral cytoplasm, but had no nuclear changes. Recovery was induced by glucose injection. Improvement in the cerebral energy state occurred during the 30 min recovery period even after 60 min of hypoglycemia. However, the persisting reduction in the size of adenine nucleotide and amino acid pools after 30 or 180 min recovery suggested that some cells remained damaged. In confirmation many type I injured neurons persisted during the recovery suggesting an irreversible injury. The disappearance of virtually all type II injuries indicated reversibility of these histopathological changes. The microscopic changes in hypoglycemia were different from those in anoxia-ischemia suggesting a dissimilar pathogenesis in these states despite the common final pathway of energy failure.
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| 3. |
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| 4. |
- Alm, P., et al.
(författare)
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Immunoglobulin-A producing probably primary lymphoma of the breast
- 1983
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Ingår i: Virchows Archiv. - 1432-2307. ; 399:3, s. 355-360
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Tidskriftsartikel (refereegranskat)abstract
- A breast tumour from a 65-year old woman was found to be a primary non-Hodgkin lymphoma, a very rare primary malignancy in this location. The lymphoma was of a diffuse histiocytic type according to the classification of Rappaport, or polymorphic immunocytoma according to the Kiel classification. Immunohistochemistry, not previously reported for breast lymphomas, revealed the production of IgA. In the serum this appeared as an IgA M-component which was greatly reduced after tumour removal. Immunological properties of primary breast lymphomas are reviewed, we suggest further extended studies with the immunohistochemical use of marker substances for the evaluation of prognosis. © 1983 Springer-Verlag.
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| 5. |
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| 6. |
- Bengner, Urban, et al.
(författare)
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Changes in incidence and prevalence of vertebral fractures during 30 years
- 1988
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Ingår i: Calcified Tissue International. - 1432-0827. ; 42:5, s. 293-296
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Tidskriftsartikel (refereegranskat)abstract
- The age and sex-specific incidence and prevalence of vertebral compression fractures were compared between the 1950s and 1980s in an urban population. In women over 80 years of age the incidence of symptomatic vertebral fractures has increased approximately four times; in elderly men even more. Mainly, low-energy trauma has caused these fractures. Thus, one clinical manifestation of osteoporosis--vertebral fracture--has increased in number, incidence, and prevalence over the last 30 years.
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| 7. |
- Bengtsson, Hans, et al.
(författare)
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Parental feeding rate in relation to begging behavior in asynchronously hatched broods of the great tit Parus major: An experimental study.
- 1983
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Ingår i: Behavioral Ecology and Sociobiology. - 1432-0762. ; 12:3, s. 243-251
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Tidskriftsartikel (refereegranskat)abstract
- Four experiments manipulated the stimulus situation encountered by great tits on their feeding visits to the brood in order to explore its effect on feeding rate. Three broods containing 8, 8, and 10 nestlings were studied. A higher feeding rate was observed under the following conditions: (1) after a period of food deprivation, as compared with normal conditions and satiation through artifical feeding; (2) in periods when recorded begging calls were played during feeding visits, as compared with control periods; and (3) after temporary removal from the nest of heavier, as compared with lighter, siblings. The lighter nestlings benefitted more (in terms of weight gain) from the increase in parental feeding rate following the playing of begging calls than did the heavier nestlings. Differences in weight within broods did not affect the amount of food the parents brought. It is concluded that parental feeding rate is affected not simply by the begging of the hungriest nestling but rather by the behavior of all the nestlings, which makes possible an adjustment of the feeding rate to the average hunger level of the brood.
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| 8. |
- Bergqvist, David, et al.
(författare)
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The economics of general thromboembolic prophylaxis
- 1988
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Ingår i: World Journal of Surgery. - 1432-2323. ; 12:3, s. 349-355
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Tidskriftsartikel (refereegranskat)abstract
- The clinical and economic effects of each of 3 alternatives—no prophylaxis, general prophylaxis, and selective treatment—have been assessed in conjunction with 3 types of surgery—general surgery, the subset surgery for cholelithiasis, and elective hip surgery. The costs of thromboembolic and hemorrhagic complications have been calculated from the figures for 28 patients hospitalized at the Department of Surgery, Malmö General Hospital, Malmö, Sweden. The anticipated number of thromboembolic complications—and thus even the number of fatal pulmonary embolisms—can be minimized in all 3 types of surgery by means of general prophylaxis. General prophylaxis with low-dose heparin is, however, accompanied by the greatest incidence of hemorrhagic complications. Health care costs are minimized with general prophylaxis in elective hip and general surgery, while no prophylaxis is the best alternative in surgery for cholelithiasis. From the patient's point of view, general prophylaxis minimizes the duration of thromboembolic disease in general surgery as well as in elective hip surgery. In surgery for cholelithiasis, however, no differences in health loss for the individual are shown between the 2 main alternatives, no prophylaxis and general prophylaxis. Selective treatment means treatment after diagnosis of thrombosis with some screening method. The alternative selective treatment was the least satisfactory of those 3 studied.
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| 9. |
- Bååth, Erland, et al.
(författare)
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Fungal populations in podzolic soil experimentally acidified to simulate acid-rain
- 1984
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Ingår i: Microbial Ecology. - 1432-184X. ; 10:3, s. 197-203
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Tidskriftsartikel (refereegranskat)abstract
- Abstract in UndeterminedThe effect of experimental acidification on the soil microfungalcommunity was studied in the humus layer of a coniferous forest in northern Sweden. The study was made 4 years after the last application of sulfuric acid. Fungal species composition was altered by treatments of 100 and 150 kg sulfuric acid ha-1 each year for 6 years, yet no differences were found between the control treatment and an application of 50 kg ha-1. The abundance of Penicillium spinulosum and Oidiodendron cf. echinulatum II increased with increasing rates of acid application, whereas only small changes were found for other isolated fungal taxa. Soil respiration rate and fluorescein diacetate (FDA)-active fungal biomass were significantly different from the control treatment at all 3 levels of acidification.
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| 10. |
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