Sökning: L773:1441 0745 OR L773:1442 2018
> Holscher A >
Surgical management...
Surgical management of esophageal sarcoma: a multicenter European experience
-
Mege, D (författare)
-
Depypere, L (författare)
-
Piessen, G (författare)
-
visa fler...
-
Slaman, AE (författare)
-
Wijnhoven, BPL (författare)
-
Holscher, A (författare)
-
- Nilsson, M (författare)
- Karolinska Institutet
-
Henegouwen, MIV (författare)
-
van Lanschot, JJB (författare)
-
Schroeder, W (författare)
-
Thomas, PA (författare)
-
Nafteux, P (författare)
-
D'Journo, XB (författare)
-
visa färre...
-
(creator_code:org_t)
- 2018-02-09
- 2018
- Engelska.
-
Ingår i: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. - : Oxford University Press (OUP). - 1442-2050. ; 31:3
- Relaterad länk:
-
http://kipublication...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Esophageal sarcomas are rare and evidence in literature is scarce making their management difficult. The objective is to report surgical and oncological outcomes of esophageal sarcoma in a large multicenter European cohort. This is a retrospective multicenter study including all patients who underwent en-bloc esophagectomy for esophageal sarcoma in seven European tertiary referral centers between 1987 and 2016. The main outcomes and measures are pathological results, early and long-term outcomes. Among 10,936 esophageal resections for cancer, 21 (0.2%) patients with esophageal sarcoma were identified. The majority of tumors was located in the middle (n = 7) and distal (n = 9) third of the esophagus. Neoadjuvant chemoradiotherapy was performed in five patients. All the patients underwent en-bloc transthoracic esophagectomy (19 open, 2 minimally invasive). Postoperative mortality occurred in 1 patient (5%). One patient received adjuvant chemotherapy. Definitive pathological results were carcinosarcoma (n = 7), leiomyosarcoma (n = 5), and other types of sarcoma (n = 9). Microscopic R1 resection was present in one patient (5%) and seven patients (33%) had positive lymph nodes. Median follow-up was 16 (3–79) months in 20 of 21 patients (95%). One-, 3-, and 5-year overall survival rates were 74%, 43%, and 35%, respectively. One-, 3- and 5-years disease-free survival rates were 58%, 40%, and 33%, respectively. Median overall survival was 6 months in N+ patients vs. 37 months for N0 patients (p = 0.06). At the end of the follow-up period, nine patients had died from cancer recurrences (43%), three patients died from other reasons (14%), one patient was still alive with recurrence (5%) and the seven remaining patients were free of disease (33%). Recurrence was local (n = 3), metastatic (n = 3), or both (n = 4). In conclusion, carcinosarcoma and leiomyosarcoma were the most common esophageal sarcoma histological subtypes. Lymph node involvement was seen in one third of cases. A transthoracic en-bloc esophagectomy with radical lymphadenectomy should be the best surgical option to achieve complete resection. Long-term survival remained poor with a high local and distant recurrence rate.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Mege, D
-
Depypere, L
-
Piessen, G
-
Slaman, AE
-
Wijnhoven, BPL
-
Holscher, A
-
visa fler...
-
Nilsson, M
-
Henegouwen, MIV
-
van Lanschot, JJ ...
-
Schroeder, W
-
Thomas, PA
-
Nafteux, P
-
D'Journo, XB
-
visa färre...
- Artiklar i publikationen
-
Diseases of the ...
-
Diseases of the ...
- Av lärosätet
-
Karolinska Institutet