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Sökning: L773:1539 3704

  • Resultat 1-10 av 82
  • [1]234567...9Nästa
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  • Adami, Johanna, et al. (författare)
  • Blood transfusion and non-Hodgkins lymphoma : Lack of association
  • 1997
  • Ingår i: Annals of Internal Medicine. - 0003-4819 .- 1539-3704. ; 127:5, s. 365-371
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>BACKGROUND: Non-Hodgkin lymphoma is the seventh most commonly diagnosed malignant condition worldwide, and its incidence has increased markedly in recent decades. Blood transfusions have been implicated as a possible risk factor for non-Hodgkin lymphoma. OBJECTIVE: To determine whether blood transfusions are associated with an elevated risk for non-Hodgkin lymphoma. DESIGN: Population-based, nested case-control study. SETTING: Nationwide cohort in Sweden. PATIENTS: 361 patients with non-Hodgkin lymphoma and 705 matched controls, nested within a population-based cohort of 96795 patients at risk for blood transfusion between 1970 and 1983. Prospectively collected information on exposure was retrieved from computerized transfusion registries. MEASUREMENTS: Odds ratios obtained from conditional logistic regression models were used as measures of relative risks. RESULTS: No association was found between blood transfusions and the risk for non-Hodgkin lymphoma when patients who had received transfusions were compared with patients who had not received transfusions (odds ratio, 0.93 [95% CI, 0.71 to 1.23]). A reduction in risk was seen among persons who received transfusion of blood without leukocyte depletion (odds ratio, 0.72 [CI, 0.53 to 0.97]). Risk was not related to number of transfusions, and no interaction was seen with latency after transfusion. CONCLUSION: The findings in this study do not support previous observations of an association between blood transfusions and the risk for non-Hodgkin lymphoma.</p>
  • Axelsen, M, et al. (författare)
  • Postprandial hypertriglyceridemia and insulin resistance in normoglycemic first-degree relatives of patients with type 2 diabetes.
  • 1999
  • Ingår i: Annals of Internal Medicine. - 0003-4819 .- 1539-3704. ; 131:1, s. 27-31
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>BACKGROUND:</strong> Impaired ability to eliminate lipids in the postprandial state is an atherogenic trait associated with insulin resistance.</p><p><strong>OBJECTIVE:</strong> To assess insulin sensitivity and postprandial triglyceride metabolism in prediabetic persons.</p><p><strong>DESIGN:</strong> Cross-sectional study.</p><p><strong>SETTING:</strong> Sahlgrenska University Hospital, Göteborg, Sweden.</p><p><strong>PARTICIPANTS:</strong> 13 healthy, normotriglyceridemic men with two first-degree relatives with type 2 diabetes and 13 carefully matched controls without known diabetes heredity.</p><p><strong>MEASUREMENTS:</strong> Oral glucose tolerance test, insulin sensitivity (euglycemic clamp technique), and fasting and postprandial triglyceride levels after a mixed meal.</p><p><strong>RESULTS:</strong> Relatives of persons with type 2 diabetes were insulin resistant but had normal glucose tolerance. They exhibited postprandial hypertriglyceridemia; the 6-hour triglyceride incremental area under the curve was 50% higher than that of the control group (P = 0.037).</p><p><strong>CONCLUSIONS:</strong> These healthy male first-degree relatives of patients with type 2 diabetes are insulin resistant and exhibit postprandial lipid intolerance despite having normal fasting triglyceride levels. These characteristics, which occur in the absence of glucose intolerance, are associated with an increased risk for macroangiopathy.</p>
  • Benito, Natividad, et al. (författare)
  • Health care-associated native valve endocarditis: importance of non-nosocomial acquisition.
  • 2009
  • Ingår i: Annals of internal medicine. - 1539-3704. ; 150:9, s. 586-94
  • Tidskriftsartikel (refereegranskat)abstract
    • The clinical profile and outcome of nosocomial and non-nosocomial health care-associated native valve endocarditis are not well defined.To compare the characteristics and outcomes of community-associated and nosocomial and non-nosocomial health care-associated native valve endocarditis.Prospective cohort study.61 hospitals in 28 countries.Patients with definite native valve endocarditis and no history of injection drug use who were enrolled in the ICE-PCS (International Collaboration on Endocarditis Prospective Cohort Study) from June 2000 to August 2005.Clinical and echocardiographic findings, microbiology, complications, and mortality.Health care-associated native valve endocarditis was present in 557 (34%) of 1622 patients (303 with nosocomial infection [54%] and 254 with non-nosocomial infection [46%]). Staphylococcus aureus was the most common cause of health care-associated infection (nosocomial, 47%; non-nosocomial, 42%; P = 0.30); a high proportion of patients had methicillin-resistant S. aureus (nosocomial, 57%; non-nosocomial, 41%; P = 0.014). Fewer patients with health care-associated native valve endocarditis had cardiac surgery (41% vs. 51% of community-associated cases; P < 0.001), but more of the former patients died (25% vs. 13%; P < 0.001). Multivariable analysis confirmed greater mortality associated with health care-associated native valve endocarditis (incidence risk ratio, 1.28 [95% CI, 1.02 to 1.59]).Patients were treated at hospitals with cardiac surgery programs. The results may not be generalizable to patients receiving care in other types of facilities or to those with prosthetic valves or past injection drug use.More than one third of cases of native valve endocarditis in non-injection drug users involve contact with health care, and non-nosocomial infection is common, especially in the United States. Clinicians should recognize that outpatients with extensive out-of-hospital health care contacts who develop endocarditis have clinical characteristics and outcomes similar to those of patients with nosocomial infection.None.
  • Carlsson, Sigrid, 1982-, et al. (författare)
  • Screening for prostate cancer.
  • 2012
  • Ingår i: Annals of internal medicine. - 1539-3704. ; 156:7
  • Tidskriftsartikel (övrigt vetenskapligt)
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