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Passive transfer of...
Passive transfer of fibromyalgia symptoms from patients to mice
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- Goebel, Andreas (författare)
- Walton Ctr NHS Fdn Trust, Liverpool, Merseyside, England; Univ Liverpool, Pain Res Inst, Inst Life Course & Med Sci, Liverpool, Merseyside, England
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- Krock, Emerson (författare)
- Karolinska Institutet,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
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- Gentry, Clive (författare)
- Kings Coll London, Wolfson CARD, Inst Psychiat Psychol & Neurosci, Guys Campus, London, England
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- Israel, Mathilde R. (författare)
- Kings Coll London, Wolfson CARD, Inst Psychiat Psychol & Neurosci, Guys Campus, London, England
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- Jurczak, Alexandra (författare)
- Karolinska Institutet,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
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- Morado Urbina, Carlos (författare)
- Karolinska Institutet,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
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- Sandor, Katalin (författare)
- Karolinska Institutet,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
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- Vastani, Nisha (författare)
- Kings Coll London, Wolfson CARD, Inst Psychiat Psychol & Neurosci, Guys Campus, London, England
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- Maurer, Margot (författare)
- Kings Coll London, Wolfson CARD, Inst Psychiat Psychol & Neurosci, Guys Campus, London, England
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- Cuhadar, Ulku (författare)
- Kings Coll London, Wolfson CARD, Inst Psychiat Psychol & Neurosci, Guys Campus, London, England
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- Sensi, Serena (författare)
- Univ Liverpool, Pain Res Inst, Inst Life Course & Med Sci, Liverpool, Merseyside, England
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- Nomura, Yuki (författare)
- Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
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- Menezes, Joana (författare)
- Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
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- Baharpoor, Azar (författare)
- Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
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- Brieskorn, Louisa (författare)
- Karolinska Institutet,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
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- Sandström, Angelica (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
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- Tour, Jeanette (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
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- Kadetoff, Diana (författare)
- Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden; Stockholm Spine Ctr, Upplands Väsby, Sweden
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- Haglund, Lisbet (författare)
- McGill Univ, Div Orthopaed Surg, Dept Surg, Montreal, PQ, Canada
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- Kosek, Eva (författare)
- Karolinska Institutet,Uppsala universitet,Klinisk smärtforskning,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
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- Bevan, Stuart (författare)
- Kings Coll London, Wolfson CARD, Inst Psychiat Psychol & Neurosci, Guys Campus, London, England
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- Svensson, Camilla I. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
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- Andersson, David A. (författare)
- Kings Coll London, Wolfson CARD, Inst Psychiat Psychol & Neurosci, Guys Campus, London, England
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(creator_code:org_t)
- American Society For Clinical Investigation, 2021
- 2021
- Engelska.
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Ingår i: Journal of Clinical Investigation. - : American Society For Clinical Investigation. - 0021-9738 .- 1558-8238. ; 131:13
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Fibromyalgia syndrome (FMS) is characterized by widespread pain and tenderness, and patients typically experience fatigue and emotional distress. The etiology and pathophysiology of fibromyalgia are not fully explained and there are no effective drug treatments. Here we show that IgG from FMS patients produced sensory hypersensitivity by sensitizing nociceptive neurons. Mice treated with IgG from FMS patients displayed increased sensitivity to noxious mechanical and cold stimulation, and nociceptive fibers in skin-nerve preparations from mice treated with FMS IgG displayed an increased responsiveness to cold and mechanical stimulation. These mice also displayed reduced locomotor activity, reduced paw grip strength, and a loss of intraepidermal innervation. In contrast, transfer of IgG-depleted serum from FMS patients or IgG from healthy control subjects had no effect. Patient IgG did not activate naive sensory neurons directly. IgG from FMS patients labeled satellite glial cells and neurons in vivo and in vitro, as well as myelinated fiber tracts and a small number of macrophages and endothelial cells in mouse dorsal root ganglia (DRG), but no cells in the spinal cord. Furthermore, FMS IgG bound to human DRG. Our results demonstrate that IgG from FMS patients produces painful sensory hypersensitivities by sensitizing peripheral nociceptive afferents and suggest that therapies reducing patient IgG titers may be effective for fibromyalgia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Goebel, Andreas
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Krock, Emerson
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Gentry, Clive
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Israel, Mathilde ...
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Jurczak, Alexand ...
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Morado Urbina, C ...
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visa fler...
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Sandor, Katalin
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Vastani, Nisha
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Maurer, Margot
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Cuhadar, Ulku
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Sensi, Serena
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Nomura, Yuki
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Menezes, Joana
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Baharpoor, Azar
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Brieskorn, Louis ...
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Sandström, Angel ...
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Tour, Jeanette
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Kadetoff, Diana
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Haglund, Lisbet
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Kosek, Eva
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Bevan, Stuart
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Svensson, Camill ...
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Andersson, David ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
- Artiklar i publikationen
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Journal of Clini ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet