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Träfflista för sökning "L773:1590 8658 ;pers:(Stenram Unne)"

Search: L773:1590 8658 > Stenram Unne

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  • Abu Al-Soud, Waleed, et al. (author)
  • DNA of Helicobacter spp. and common gut bacteria in primary liver carcinoma.
  • 2008
  • In: Digestive and Liver Disease. - : Elsevier BV. - 1590-8658. ; 40:2, s. 126-131
  • Journal article (peer-reviewed)abstract
    • BACKGROUND AND AIM: Gastric and enteric Helicobacter species have been associated with the pathogenesis of some extragastric diseases. METHODS: We retrospectively investigated the presence of DNA of Helicobacter species in samples of the cancer and the surrounding tumour-free liver tissues of patients with hepatocellular carcinoma (HCC, n=12) and cholangiocarcinoma (CC, n=13). The patients were from an area with low liver cancer incidence and with low hepatitis B and C prevalence. Patients with a benign liver disease (n=24) were included as controls. Paraffin-embedded liver samples were examined by a Helicobacter genus-specific PCR assay as well as group-specific PCR assays for Enterobacteriaceae, Bacteroides, Lactobacillus and Enterococcus. PCR products of positive samples were characterised by denaturing gradient gel electrophoresis (DGGE) and DNA sequencing. RESULTS: PCR assay detected Helicobacter DNA in seven of 12 (58%) and eight of 13 (62%) normal liver tissue specimens from HCC and CC patients, respectively. Two cancer samples from HCC patients were Helicobacter-positive but none of the CC cancers. In the control group, three of 24 (12.5%) patients with a benign liver condition were positive for Helicobacter species (p<0.01 compared to results of tumour-free liver tissue from the cancer patients). DGGE and DNA sequence analysis showed that 90% of the detected PCR products were "H. pylori-like". DNA of some other enteric bacteria was detected in the liver of one cancer patient and one control (4% of all patients). CONCLUSION: The presence of DNA of Helicobacter species in liver specimens, but not of other common gut bacteria, was associated with human hepatic carcinogenesis.
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Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Ljungh, Åsa (2)
Nilsson, Hans-Olof (2)
Wadström, Torkel (2)
Abu Al-Soud, Waleed (1)
Tranberg, Karl-Göran (1)
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Willen, R. (1)
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University
Lund University (2)
Uppsala University (1)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)

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