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Sökning: L773:1744 8409

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  • Kadri, Nadir, 1977, et al. (författare)
  • Type II natural killer T cells: a new target for immunomodulation?
  • 2008
  • Ingår i: Expert Review of Clinical Immunology. - 1744-666X. ; 4:5, s. 615-627
  • Forskningsöversikt (refereegranskat)abstract
    • Natural killer (NK) T lymphocytes are potent immuno regulatory cells that can regulate diverse immune responses. NKT cells display a low degree of inherent autoreactivity, and are activated by endogenous or pathogen specific glycolipids presented on the cluster of differentiation (CD)1d molecule. Recent studies have focused attention to type II NKT cells, which in contrast to type I NKT cells display a diverse T cell receptor repertoire. Type II NKT cells in mice and humans demonstrate a unique regulatory role in autoimmunity, tumor immunity and infections. Immuno therapy targeting type II NKT cells in experimental models prevents autoimmune disease and protects mice from experimental hepatitis. Current efforts aim to reveal the underlying regulatory mechanisms of type II NKT cells in mice and humans, and to identify the parameters that guide their activation, working towards the development of selective immuno therapies targeting type II NKT cells in autoimmunity and other immune mediated diseases.
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  • Ainamo, Antti, 1963-, et al. (författare)
  • Progress in the treatment and outcome of pediatric inflammatory bowel disease patients
  • 2016
  • Ingår i: Expert Review of Clinical Immunology. - Borås / Helsinki : Taylor & Francis. - 1744-8409. ; , s. 1-33
  • Forskningsöversikt (refereegranskat)abstract
    • This review discusses how treatment of pediatric inflammatory bowel disease (IBD) patients has improved with attention to therapeutic quality and cost. The number of such patients in Western countries has increased rapidly. Similarly to what has been the trend in the management of adult IBD, the pediatric IBD therapy has become more active than earlier. High use of immunosuppressants has helped to control the extensive and aggressive course of pediatric IBD. Full disease control already at an early phase has advantages such as to preserve normal child growth and development, to maintain overall good health and quality of life, as well as to decrease the psychosocial burden of the disease. A key research direction is to develop the more active approach into a way to reduce healthcare costs by decreasing the so-far high rate of surgery of pediatric IBD patients. 
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  • Resultat 1-10 av 42
  • [1]2345Nästa

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