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The cognitive defec...
The cognitive defects of neonatally irradiated miceare accompanied by changed synaptic plasticity,adult neurogenesis and neuroinflammation
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Kempf, Stefan J. (författare)
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Casciati, Arianna (författare)
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Buratovic, Sonja (författare)
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visa fler...
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Janik, Dirk (författare)
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von Toerne, Christine (författare)
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Ueffing, Marius (författare)
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Neff, Frauke (författare)
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Moertl, Simone (författare)
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Stenerlöw, Bo (författare)
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Saran, Anna (författare)
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Atkinson, Michael J. (författare)
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Eriksson, Per (författare)
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Pazzaglia, Simonetta (författare)
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Tapio, Soile (författare)
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visa färre...
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(utgivare)
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(utgivare)
- 2014
- 2014
- Engelska.
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Ingår i: Molecular Neurodegeneration. - 1750-1326. ; 9, 57
Abstract
Ämnesord
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- Background/purpose of the study: Epidemiological evidence suggests that low doses of ionising radiation(≤1.0 Gy) produce persistent alterations in cognition if the exposure occurs at a young age. The mechanismsunderlying such alterations are unknown. We investigated the long-term effects of low doses of total body gammaradiation on neonatally exposed NMRI mice on the molecular and cellular level to elucidate neurodegeneration.Results: Significant alterations in spontaneous behaviour were observed at 2 and 4 months following a single 0.5or 1.0 Gy exposure. Alterations in the brain proteome, transcriptome, and several miRNAs were analysed 6–7months post-irradiation in the hippocampus, dentate gyrus (DG) and cortex. Signalling pathways related to synapticactin remodelling such as the Rac1-Cofilin pathway were altered in the cortex and hippocampus. Further, synapticproteins MAP-2 and PSD-95 were increased in the DG and hippocampus (1.0 Gy). The expression of synapticplasticity genes Arc, c-Fos and CREB was persistently reduced at 1.0 Gy in the hippocampus and cortex. Thesechanges were coupled to epigenetic modulation via increased levels of microRNAs (miR-132/miR-212, miR-134).Astrogliosis, activation of insulin-growth factor/insulin signalling and increased level of microglial cytokine TNFαindicated radiation-induced neuroinflammation. In addition, adult neurogenesis within the DG was persistentlynegatively affected after irradiation, particularly at 1.0 Gy.Conclusion: These data suggest that neurocognitive disorders may be induced in adults when exposed at a youngage to low and moderate cranial doses of radiation. This raises concerns about radiation safety standards andregulatory practices.
Ämnesord
- Medical and Health Sciences (hsv)
- Basic Medicine (hsv)
- Neurosciences (hsv)
- Medicin och hälsovetenskap (hsv)
- Medicinska grundvetenskaper (hsv)
- Neurovetenskaper (hsv)
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Till lärosätets databas
- Av författaren/redakt...
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Kempf, Stefan J.
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Casciati, Ariann ...
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Buratovic, Sonja
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Janik, Dirk
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von Toerne, Chri ...
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Ueffing, Marius
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visa fler...
-
Neff, Frauke
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Moertl, Simone
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Stenerlöw, Bo
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Saran, Anna
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Atkinson, Michae ...
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Eriksson, Per
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Pazzaglia, Simon ...
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Tapio, Soile
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visa färre...
- Av lärosätet
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