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Sökning: L773:1759 4804

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  • Aspenberg, Per (författare)
  • Bone : Silk, metal and bone: why take implants out?
  • 2014
  • Ingår i: Nature Reviews Rheumatology. - : Nature Publishing Group. - 1759-4790 .- 1759-4804. ; 10:7, s. 386-387
  • Tidskriftsartikel (övrigt vetenskapligt)abstract
    • Degradable screws and plates for bone surgery have been produced from silk protein. The idea is to eliminate the need to take the implant out when the bone has healed. Will they provide sufficient strength, and will they degrade without causing inflammation? And why take implants out in the first place?
  • Kanis, John A, et al. (författare)
  • Approaches to the targeting of treatment for osteoporosis
  • 2009
  • Ingår i: Nature Reviews Rheumatology. - 1759-4790 .- 1759-4804. ; 5:8, s. 425-31
  • Tidskriftsartikel (refereegranskat)abstract
    • Fractures are a clinical consequence of osteoporosis, and represent a major cause of morbidity and mortality worldwide. Several treatments have been shown to decrease the risk of fracture, but problems arise in identifying individuals at high fracture risk so that treatments can be effectively targeted. The case for widespread population screening using bone mineral density testing is weak, as these tests lack sensitivity. Case-finding algorithms are available in many countries, but differ markedly in their approaches. Recent developments in fracture risk assessment include the availability of the FRAX (WHO Collaborating Center for Bone Metabolic Disease, Sheffield, UK) tool, which integrates the weight of clinical risk factors for fracture risk with or without information on bone mineral density, and computes the 10-year probability of fracture. The tool increases sensitivity without trading specificity, and is now being used in the reappraisal of clinical guidelines.
  • Sciascia, Savino, et al. (författare)
  • Differentiating between UCTD and early-stage SLE : from definitions to clinical approach
  • 2022
  • Ingår i: Nature Reviews Rheumatology. - : Nature Publishing Group. - 1759-4790 .- 1759-4804. ; 18, s. 9-21
  • Tidskriftsartikel (refereegranskat)abstract
    • Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous clinical manifestations that can potentially affect every organ and system. SLE is usually identified on the basis of clinical or serological manifestations; however, some individuals can present with signs and symptoms that are consistent with SLE but are not sufficient for a definite diagnosis. Disease in these individuals can either progress over time to definite SLE or remain stable, in which case their disease is often described as intermediate, possible or probable SLE. Alternatively, such individuals might have undifferentiated connective tissue disease (UCTD). Being able to differentiate between those with stable UCTD and those with SLE at an early stage is important to avoid irreversible target-organ damage from occurring. This Review provides insight into existing and evolving perceptions of the early stages of SLE, including clinical and mechanistic considerations, as well as potential paths towards early identification and intervention. Further research into the earliest phases of SLE will be important for the development of targeted diagnostic approaches and biomarkers for the identification of individuals with early disease who are likely to progress to definite SLE.
  • Wahren-Herlenius, Marie, et al. (författare)
  • Learning from similarities between vaccine responses and SLE
  • 2020
  • Ingår i: Nature Reviews Rheumatology. - 1759-4790 .- 1759-4804. ; 16:7, s. 355-356
  • Tidskriftsartikel (övrigt vetenskapligt)abstract
    • Baseline immune variation predicts immune responses during vaccination, and the gene signatures capturing such immune variation seem to correlate with systemic lupus erythematosus (SLE) disease activity. Will the definition of these gene sets enable the development of the much needed concept of personalized medicine in SLE?
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  • Resultat 1-10 av 40
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