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Characterization of...
Characterization of three Mycobacterium spp. with potential use in bioremediation by genome sequencing and comparative genomics
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- Das, Sarbashis (författare)
- Uppsala universitet,Kemisk biologi
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- Pettersson, B M Fredrik (författare)
- Uppsala universitet,Kemisk biologi
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- Behra, Phani Rama Krishna (författare)
- Uppsala universitet,Kemisk biologi
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- Ramesh, Malavika (författare)
- Uppsala universitet,Kemisk biologi
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- Dasgupta, Santanu (författare)
- Uppsala universitet,Mikrobiologi
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Bhattacharya, Alok (författare)
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- Kirsebom, Leif A (författare)
- Uppsala universitet,Kemisk biologi
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(creator_code:org_t)
- 2015-06-16
- 2015
- Engelska.
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Ingår i: Genome Biology and Evolution. - : Oxford University Press (OUP). - 1759-6653. ; 7:7, s. 1871-1886
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We provide the genome sequences of the type strains of the polychlorophenol-degrading Mycobacterium chlorophenolicum (DSM43826), the degrader of chlorinated aliphatics Mycobacterium chubuense (DSM44219) and Mycobacterium obuense (DSM44075) that has been tested for use in cancer immunotherapy. The genome sizes of M. chlorophenolicum, M. chubuense and M. obuense are 6.93, 5.95 and 5.58 Mbps with GC-contents of 68.4, 69.2 and 67.9%, respectively. Comparative genomic analysis revealed that 3254 genes are common and we predicted approximately 250 genes acquired through horizontal gene transfer from different sources including proteobacteria. The data also showed that the biodegrading Mycobacterium spp. NBB4, also referred to as M. chubuense NBB4, is distantly related to the M. chubuense type strain and should be considered as a separate species, we suggest it to be named M. ethylenense NBB4. Among different categories we identified genes with potential roles in: biodegradation of aromatic compounds, and copper homeostasis. These are the first non-pathogenic Mycobacterium spp. found harboring genes involved in copper homeostasis. These findings would therefore provide insight into the role of this group of Mycobacterium spp. in bioremediation as well as the evolution of copper homeostasis within the Mycobacterium genus.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Miljöbioteknik -- Biosanering (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Environmental Biotechnology -- Bioremediation (hsv//eng)
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