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> Ellegaard Kirsten M. >
Functionally Struct...
Functionally Structured Genomes in Lactobacillus kunkeei Colonizing the Honey Crop and Food Products of Honeybees and Stingless Bees
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- Tamarit, Daniel (författare)
- Uppsala University,Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab
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- Ellegaard, Kirsten M. (författare)
- Uppsala University,Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab
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- Wikander, Johan (författare)
- Uppsala University,Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab
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- Olofsson, Tobias (författare)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Honungsgruppen,Forskargrupper vid Lunds universitet,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine,Honey group,Lund University Research Groups
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- Vasquez, Alejandra (författare)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine
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- Andersson, Siv G. E. (författare)
- Uppsala University,Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2015-05-06
- 2015
- Engelska.
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Ingår i: Genome Biology and Evolution. - : Oxford University Press (OUP). - 1759-6653. ; 7:6, s. 1455-1473
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Abstract
Ämnesord
Stäng
- Lactobacillus kunkeei is the most abundant bacterial species in the honey crop and food products of honeybees. The 16 S rRNA-genes of strains isolated from different bee species are nearly identical in sequence and therefore inadequate as markers for studies of coevolutionary patterns. Here, we have compared the 1.5Mb genomes of ten L. kunkeei strains isolated from all recognized Apis species and another two strains from Meliponini species. Agene flux analysis, including previously sequenced Lactobacillus species as outgroups, indicated the influence of reductive evolution. The genome architecture is unique in that vertically inherited core genes are located near the terminus of replication, whereas genes for secreted proteins and putative host-adaptive traits are located near the origin of replication. We suggest that these features have resulted from a genome-wide loss of genes, with integrations of novel genes mostly occurring in regions flanking the origin of replication. The phylogenetic analyses showed that the bacterial topology was incongruent with the host topology, and that strains of the same microcluster have recombined frequently across the host species barriers, arguing against codiversification. Multiple genotypes were recovered in the individual hosts and transfers of mobile elements could be demonstrated for strains isolated from the same host species. Unlike other bacteria with small genomes, short generation times and multiple rRNA operons suggest that L. kunkeei evolves under selection for rapid growth in its natural growth habitat. The results provide an extended framework for reductive genome evolution and functional genome organization in bacteria.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- genome organization
- Lactobacillus kunkeei
- honeybee
- genome reduction
- recombination
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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