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Träfflista för sökning "L773:1872 7980 ;pers:(Andersson Engels Stefan)"

Sökning: L773:1872 7980 > Andersson Engels Stefan

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1.
  • Heyerdahl, H, et al. (författare)
  • Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues
  • 1997
  • Ingår i: Cancer Letters. - 1872-7980. ; 112:2, s. 225-231
  • Tidskriftsartikel (refereegranskat)abstract
    • Laser-induced fluorescence (LIF) for in vivo point monitoring and fluorescence microscopy incorporating a CCD camera were used to study the fluorescence distribution of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in tumours. Fluorescence in a chemically induced adenocarcinoma in the liver of rats and in an aggressive basal cell carcinoma in a patient were studied after intravenous injection of ALA at a dose of 30 mg/kg body weight. The LIF technique demonstrated slightly more ALA-induced PpIX fluorescence in the tumour than in the surrounding normal liver and abdominal muscle of rats. The visible parts of the human basal cell carcinoma exhibited strong ALA-induced fluorescence, while this fluorescence was much weaker in the necrotic areas of the tumour and in the surrounding normal skin. (C) 1997 Elsevier Science ireland Ltd.
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2.
  • Liu, D. L, et al. (författare)
  • Tumour vessel damage resulting from laser-induced hyperthermia alone and in combination with photodynamic therapy
  • 1997
  • Ingår i: Cancer Letters. - 1872-7980. ; 111:1-2, s. 157-165
  • Tidskriftsartikel (refereegranskat)abstract
    • This study examined tumour vessel injury resulting from laser-induced hyperthermia alone and in combination with photodynamic therapy (PDT) in the treatment of rat liver tumours by means of scanning electron microscopy. A total of 18 Wistar rats were divided into three groups, Group I (six animals) underwent hyperthermia for 15 min (15-min hyperthermia). Group II (six animals) underwent hyperthermia for 30 min (30-min hyperthermia). Group III (six animals) received the combined treatment of PDT and 30-min hyperthermia. For PDT, delta-amino laevulinic acid at a dose of 60 mg/kg of body weight was intravenously administered 60 min before irradiation at 635 nm. The morphological results indicated that 15-min hyperthermia gave rise to an increase in permeability of the vessels in the treated tumour. Thirty-min hyperthermia caused extreme oedema of vascular endothelial cells and restrictive openings of tumour branch vessels. The combined therapy of PDT and hyperthermia destroyed tumour vasculature. Large breaks of the inner wall of the treated tumour vessels were deeply involved in the basement membrane of the vessel. The results indicate that there may be a close link between inhibition of tumour growth and degree of damage to tumour vessels. (C) 1997 Elsevier Science Ireland Ltd.
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  • Resultat 1-2 av 2
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Andersson-Engels... (2)Ta bort avgränsningen
Svanberg, Sune (2)
Svanberg, Katarina (2)
Liu, D. L (2)
Wang, I (1)
Sturesson, C (1)
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Berg, R (1)
Moan, J. (1)
Heyerdahl, H (1)
Peng, Q (1)
Hakansson, C. H (1)
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Lunds universitet (2)
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Medicin och hälsovetenskap (2)
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1997 (2)

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