| 1. |
- Delaine, Tamara, 1981, et al.
(författare)
-
A structure activity relationship study of geranial derivatives
- 2012
-
Ingår i: Contact Dermatitis 11th congress of the European society of contact dermatitis (ESCD) 13-16 june 2012, Malmö, Sweden. - : Wiley. ; 66:Suppl. 2
-
Konferensbidrag (refereegranskat)abstract
- Background: Fragrances are common causes of contact allergy. Skin exposure to geranial is frequent since citral (mixture of geranial and neral) is commonly used in fragrances and flavors and is considered as a moderate allergen. Previous studies according to the local lymphnodeassay (LLNA)in micehaverevealed large variations in the sensitizing capacity of different geranial derivatives. Objectives: For a better understanding of these variations, a structure-activity relationship (SAR) study on a series of derivatives of geranial was carried out. Methods: The chemical reactivity of the compounds towards a model peptide was investigated using LC-MS. The adduct formation and the non-reacted peptide depletion were monitored. Adducts formed with model amino acids were investigated and structural determination was performed. Additional derivatives were synthesized and their sensitization potencies were evaluated in relation to their physicochemical and reactivity properties. Results: Most of the derivatives were shown to bind covalently to the cysteine residue of the model peptide. The percentage of depletion of the non-reacted peptide ranged from 0% to 100% after 24 hr, constant rate of depletion revealed a large difference between the fastest and lowest reacting derivatives. These resultswere congruent with the skin sensitization potencies obtained with the LLNA. Conclusions: A good correlation between the reactivity and the sensitizing potency was observed. Small changes in the chemical structure of geranial result in significant differences in sensitizing capacity and chemical reactivity. Conflicts of interest: The authors have declared no conflicts.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Brink, Eva, 1952
(författare)
-
Fatigue after myocardial infarction – to be considered more fully in cardiovascular nursing
- 2012
-
Ingår i: European Journal of Cardiovascular Nursing. - : Oxford University Press (OUP). - 1474-5151 .- 1873-1953. ; 11:Suppl 1
-
Konferensbidrag (refereegranskat)abstract
- Purpose: The aim of the present study was to investigate the influences of fatigue, sense of coherence and optimism on health-related quality of life (HRQL) in persons who have been treated for myocardial infarction one year after hospitalisation. Methods: The sample consisted of 98 persons, 33 women and 65 men (response rate, 74%) with a mean (SD) age of 67.88 (9.93) years. They had been treated for myocardial infarction in a coronary care unit at a Swedish rural hospital. Now, they participated in a 1-year follow-up study including questionnaires about fatigue, sense of coherence, optimism and HRQL (SF-36). Correlation and regression analyses were performed to explore relationships between variables and to identify variables that best explained the variance of the physical component score (PCS) and the mental component score (MCS) of HRQL. Results: The two regression models for analyses of PCS and MCS included fatigue, sense of coherence and optimism, controlling for age and gender. The results showed that the explained variance of PCS was 47.4%, F(5, 91) = 16.43 and that fatigue (p < 0.001) and sense of coherence (p < 0.05) contributed significantly to the variance. The explained variance of MCS was 48.9%, F(5, 91) = 17.44 and fatigue (p < 0.001) and optimism (p < 0.01) contributed significantly to the variance. Conclusion: Experiences of fatigue after myocardial infarction will have negative influences on both the physical and mental dimensions of HRQL. Compared to sense of coherence and optimism, fatigue was found to be a stronger predictor of HRQL. Clearly, it is time to take patients who suffer from post-myocardial infarction fatigue seriously. It is of vital importance to develop and evaluate fatigue relief strategies in cardiovascular nursing.
|
|
| 6. |
|
|
| 7. |
- Dudas, Kerstin, 1963, et al.
(författare)
-
PCC- Impact at admission and discharge process, among patients with chronic heart failure
- 2013
-
Ingår i: European Journal of Cardiovascular Nursing. - : Oxford University Press (OUP). - 1474-5151 .- 1873-1953. ; 12:Supplement 1, s. 66-67
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Background: Chronic heart failure (CHF) mostly affects the elderly and is a lifelong and progressive disease and the single most common cause of hospitalization with frequent re-admissions. Although many patients with CHF are independent, some patients are fragile and need extra support and care during the hospital stay and after discharge to prevent disability. A person-centred care (PCC) approach to care and planning may help to promote more efficient care and discharge-planning. Aim: To evaluate if PCC-based proactive care-planning, beginning already at admission, leads to improved efficiency in the discharge procedure compared with usual care in patients hospitalized for worsening CHF. Methods: Using a controlled before-and-after design, eligible patients with CHF were randomly assigned to either a usual care group or a PCC intervention group. Development of the PCC care and discharge plan consisted of three steps: 1) a comprehensive narrative was obtained from the patients at admission to identify each patient’s resources for and barriers to recovery; 2) a PCC plan was drawn up based on this and other clinical information and discussed with the patient Downloaded from cnu.sagepub.com at Gothenburg University Library on December 15, 2013 EuroHeartCare 2013 S67 3) the PCC plan was checked and revised where appropriate. The patients’ social situation before admission, their discharge destination, the number of days until the discharge notification was sent to the patients’ community home help service/district nurse were recorded as well as the time interval between notification and start of coordination of care between hospital staff and community home help services and district nurses. Results: 123 in the usual care group and 125 were enrolled. Most of the patients came from independent living (93.2% in the PCC group and 93.5% in the usual care group). The proportion of patients who had community home help service before admission was slightly lower in the PCC group (32.4%) compared to the usual care group (35.8%). The proportion of patients who received care from a district nurse was slightly higher in the PCC group (18.9%) than in the usual care group (13.1%). During hospitalization, the notification to the patients community home help service and/or district nurse were significantly (P = 0.04) more frequently in the PCC-group (33.8%) compared to usual care group (12.1%). Care coordination started within six days in the PCC group whereas the usual care group was more dispersed 1-29 days. Conclusion: PCC improved significantlythe efficiency of the transfer process for patients in need of community home help service and/or district nurse after discharge.
|
|
| 8. |
- Flemme, Inger, et al.
(författare)
-
Quality of profile 1 and 5 years after ICD implantation
- 2004
-
Ingår i: European Journal of Cardiovascular Nursing. - Amsterdam : Elsevier. - 1873-1953.
-
Konferensbidrag (refereegranskat)abstract
- Aim: Treatment with implantable cardioverter defibrillators (ICDs) increases survival in patients suffering from ventricular tachyarrhythmias. The physiologic effects of having an ICD implanted are well-known but there is still limited knowledge about quality of life (QoL), especially in a long-term perspective. Therefore, the aim of this prospective, follow-up study was to describe and compare uncertainty and QoL at year 1 and year 5 after implantation in patients living with an ICD.Methods: The Mishel Uncertainty in Illness Scale-community version (MUIS-C) and Quality of Life Index-cardiac version (QLI) was used for 35 patients, living with an ICD in average 6 years 9 months. Higher scores indicate higher uncertainty and QoL.Results: An improvement in uncertainty was found at year 5 compared to year 1 (p=0.009), and at year 5 compared to baseline (p = 0.009). Overall QoL decreased at year 1 compared to baseline (p = 0.033). QoL in the socioeconomic domain decreased at year 1 compared to baseline (p = 0.006), and increased at year 5 compared to year 1 (p=0.027). QoL in the family domain decreased at year 5 compared to year 1 (p=0.039), and at year 5 compared to baseline (p=<0.001).Conclusion: Patients with ICD feel better at year 5 than at year 1. The QoL is reasonable good 5 years after implant once they have passed the first years and adapted to lifestyle changes, and patients are more certain and perceive the ICD as a parachute of life.
|
|
| 9. |
- Fors, Andreas, 1977, et al.
(författare)
-
Validation of the Swedish cardiac self-efficacy scale
- 2014
-
Ingår i: European Journal of Cardiovascular Nursing. - : Oxford University Press (OUP). - 1474-5151 .- 1873-1953.
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Purpose: Self-efficacy is patients’ confidence in their ability to initiate and maintain self-care. The purpose of this study was to validate the Swedish version of the Cardiac Self-Efficacy Scale (CSES) as a first step in preparing an evaluation of a person-centred care intervention. Methods: The study sample consisted of 288 patients (72 women, 216 men; mean age 61.6) who completed the CSES two months after hospitalization for an event of acute coronary syndrome (ACS). Construct validity was psychometrically evaluated by using confirmatory factor analysis. Model fit evaluation was estimated by performing the following tests: Chi2, the Comparative Fit Index (CFI), the Standardized Root Mean Square Residual (SRMR) and the Root Mean Square Error of Approximation (RMSEA). Results: Tentative findings indicated that the Swedish version of CSES was represented by three dimensions in comparison with the original version of the CSES that comprises two dimensions; control symptoms and maintain functioning. That is, the Swedish version of the CSES includes two factors within the control symptom dimension (compared to one in the original CSES version) while the maintain function remained as stable. Conclusions: The Swedish version of the CSES seems to be a reliable and valid measure of cardiac self-efficacy. Further it is an easily understandable questionnaire and a useful tool to identify patients’ level of cardiac specific self-efficacy.
|
|
| 10. |
|
|
