SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:1879 3169 "

Sökning: L773:1879 3169

  • Resultat 1-10 av 194
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Ali, Imran, et al. (författare)
  • From pure compounds to complex exposure : Effects of dietary cadmium and lignans on estrogen, epidermal growth factor receptor, and mitogen activated protein kinase signaling in vivo.
  • 2016
  • Ingår i: Toxicology Letters. - : Elsevier BV. - 0378-4274 .- 1879-3169. ; 253
  • Tidskriftsartikel (refereegranskat)abstract
    • Exposure to environmental endocrine active compounds correlates with altered susceptibility to disease in human populations. Chemical risk assessment is single compound based, although exposure often takes place as heterogeneous mixtures of man-made and natural substances within complex matrices like diet. Here we studied whether the effects of cadmium and enterolactone on endocrine endpoints in dietary exposure can be predicted based on pure compound effects. Ovariectomized estrogen reporter ERE-luciferase (ERE-luc) mice were maintained on diets that intrinsically contain increasing concentrations of cadmium and enterolactone precursors for three and 21 days. The activation of the ERE-luc, epidermal growth factor receptor (EGFR), mitogen activated protein kinase (MAPK)-ERK1/2, and classical estrogen responses were measured. Interactions between the diets and endogenous hormone were evaluated by challenging the animals with 17β-estradiol. Compared to animals on basal purified diet, mice consuming experimental diets were exposed to significantly higher levels of cadmium and enterolactone, yet the exposure remained comparable to typical human dietary intake. Surprisingly, we could not detect effects on endpoints regulated by pure enterolactone, such as ERE-luc activation. However, cadmium accumulation in the liver was accompanied with activation of EGFR and MAPK-ERK1/2 in line with our earlier CdCl2 studies. Further, attenuation of 17β-estradiol-induced ERE-luc response in liver by experimental diets was observed. Our findings indicate that the exposure context can have substantial effects on the activity of endocrine active compounds in vivo. Thus, whenever possible, a context that mimics human exposure should be tested along with pure compounds.
  •  
3.
  •  
4.
  •  
5.
  • Alvarez-Lloret, Pedro, et al. (författare)
  • Effects of 3,3',4,4',5-pentachlorobiphenyl (PCB126) on vertebral bone mineralization and on thyroxin and vitamin D levels in Sprague-Dawley rats
  • 2009
  • Ingår i: Toxicology Letters. - : Elsevier BV. - 0378-4274 .- 1879-3169. ; 187:2, s. 63-68
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of the present study is to use Fourier transform infrared spectrometry (FTIR), and transmission electron microscopy (TEM) techniques, to make a more detailed description of toxic effects of 3,3',4,4',5-pentachlorobiphenyl (PCB126) on bone tissue at the microstructural and at the molecular level as a result of an altered bone metabolism. We have analysed potential changes on vitamin D and thyroxin serum levels since these hormones represent endocrine endpoints that are critical for bone growth and development. For this purpose Sprague-Dawley rats were exposed (n=10) to PCB126 (i.p.) for 3 months (total dose, 384microg/kg bodyweight), while control rats (n=10) were injected with corn oil (vehicle). Results from FTIR showed that vertebrae from the exposed rats had an overall lower degree of mineralization (-8.5%; p<0.05) compared with the controls. In addition, results from peripheral quantitative computed tomography (pQCT) analyses showed significant increases in the trabecular bone mineral density (+12%; p<0.05) in the exposed group compared with the controls. The TEM analyses also showed an alteration in the crystallinity properties of vertebral bone mineral with a significant decrease in the size and crystallinity of apatite crystal forming the bone tissue in the exposed vs. non-exposed rats. Serum analysis revealed lower levels of thyroid hormones, FT4 (-42%; p<0.005), TT4 (-26%; p<0.005), and vitamin D (-21%; p<0.005) in exposed group compared to control animals. The complementary techniques (TEM and FTIR) used in this study have revealed insights into possible bone mineralization alteration due to PCB126 exposure. The lowering of both the thyroxin and vitamin D serum levels might be an underlying explanation for the observed effects on bone mineralization.
  •  
6.
  • Andersson, Marie, 1974-, et al. (författare)
  • Transfer of developmental neurotoxin beta-N-methylamino-L-alanine (BMAA) via milk to nursed offspring : Studies by mass spectrometry and image analysis
  • 2016
  • Ingår i: Toxicology Letters. - : Elsevier BV. - 0378-4274 .- 1879-3169. ; 258, s. 108-114
  • Tidskriftsartikel (refereegranskat)abstract
    • The cyanobacterial non-proteinogenic amino acid beta-N-methylamino-L-alanine (BMAA) is proposed to be involved in the etiology of amyotrophic lateral sclerosis/parkinsonism dementia complex. When administered as single doses to neonatal rats, BMAA gives rise to cognitive and neurodegenerative impairments in the adult animal. Here, we employed mass spectrometry (LC-MS/MS) and autoradiographic imaging to examine the mother-to-pup transfer of BMAA in rats. The results show that unchanged BMAA was secreted into the milk and distributed to the suckling pups. The concentration of BMAA in pup stomach milk and the neonatal liver peaked after 8 h, while the concentration in the pup brain increased throughout the study period. About 1 and 6% of the BMAA recovered from adult liver and brain were released following hydrolysis, suggesting that this fraction was associated with protein. No association to milk protein was observed. Injection of rat pups with [methyl-C-14]-L-BMAA or [carboxyl-C-14]-L-BMAA resulted in highly similar distribution patterns, indicating no or low metabolic elimination of the methylamino- or carboxyl groups. In conclusion, BMAA is transported as a free amino acid to rat milk and suckling pups. The results strengthen the proposal that mothers' milk could be a source of exposure for BMAA in human infants. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
  •  
7.
  • Andersson, Patrik, et al. (författare)
  • Toxicity with LXR agonists – Problem solving activities for mechanistic understanding
  • 2012
  • Ingår i: Toxicology Letters. - Shannon : Elsevier. - 0378-4274 .- 1879-3169. ; 211:Suppl. (S), s. S39-S39
  • Tidskriftsartikel (refereegranskat)abstract
    • Several lines of evidence points toward the potential positive effects of LXR (Liver X Receptor) modulators for effective and safe therapy of cardiovascular diseases (CVDs). LXR is a dimeric nuclear hormone receptor that exists as a combination of RXR and one of two subtypes LXR alpha or beta, which act as cholesterol sensors. LXR alpha is highly expressed in the liver, intestine and adipose tissue while LXR beta is ubiquitously expressed. Activation of LXR up-regulates several genes involved in reverse cholesterol transport (RCT), including ABC transporters. This results in increased efflux of cholesterol from macrophages in atherosclerotic vascular lesions to the circulation and further on to other tissues to ultimately be excreted into the faeces. These effects together with systemic and local anti-inflammatory properties of LXR modulation are likely to contribute to decreased atherosclerosis. The positive effects of LXR activation on RCT and cholesterol balance must be obtained without negative lipid effects, since LXR also activates lipogenic genes. Other types of toxicity and approaches to better understand the mechanism(s) behind these will be presented. Copyright © 2012 Published by Elsevier Ireland Ltd.
  •  
8.
  •  
9.
  •  
10.
  • Aspenström-Fagerlund, Bitte, et al. (författare)
  • Oleic acid increases intestinal absorption of the BCRP/ABCG2 substrate, mitoxantrone, in mice
  • 2015
  • Ingår i: Toxicology Letters. - : Elsevier BV. - 0378-4274 .- 1879-3169. ; 237:2, s. 133-139
  • Tidskriftsartikel (refereegranskat)abstract
    • The efflux transporter breast cancer resistance protein (BCRP/ABCG2) decrease intestinal absorption of many food toxicants. Oleic acid increases absorption of the specific BCRP substrate mitoxantrone (MXR), and also BCRP gene expression in human intestinal Caco-2 cells, suggesting that oleic acid affect the BCRP function. Here, we investigated the effect of oleic acid on intestinal absorption of MXR in mice. Mice were orally dosed with 2.4 g oleic acid/kg b.w. and 1 mg MXR/kg b.w., and sacrificed 30, 60, 90 or 120 min after exposure, or were exposed to 0.6, 2.4 or 4.8 g oleic acid/kg b.w. and 1mg MXR/kg b.w., and sacrificed 90 min after exposure. Mice were also treated with Ko143 together with MXR and sacrificed after 60 min, as a positive control of BCRP-mediated effects on MXR absorption. Absorption of MXR increased after exposure to oleic acid at all doses, and also after exposure to Ko143. Intestinal BCRP gene expression tended to increase 120 min after oleic acid exposure. Our results in mice demonstrate that oleic acid decreases BCRP-mediated efflux, causing increased intestinal MXR absorption in mice. These findings may have implications in humans, concomitantly exposed to oleic acid and food contaminants that, similarly as MXR, are substrates of BCRP.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 194
Typ av publikation
tidskriftsartikel (172)
konferensbidrag (20)
annan publikation (2)
Typ av innehåll
refereegranskat (133)
övrigt vetenskapligt/konstnärligt (61)
Författare/redaktör
Hansson, Sven Ove (15)
Lind, Lars (9)
Skerfving, Staffan (7)
Lundh, Thomas (4)
Sjogren, B (4)
Hakansson, H (4)
visa fler...
Lampa, Erik (3)
Chawade, Aakash (3)
Larsson, Sune (3)
Sjunnesson, Ylva (3)
Örberg, Jan (3)
Akesson, A. (3)
Holmquist, Björn (3)
Vahter, Marie (3)
Bergman, Åke (3)
Halldin, Krister (3)
Damdimopoulou, P (3)
Oskarsson, A. (2)
Abramsson-Zetterberg ... (2)
Fick, Jerker (2)
Nilsson, Mats (2)
Broberg Palmgren, Ka ... (2)
Uhlén, Mathias (2)
Nilsson, Peter (2)
Abedi-Valugerdi, Man ... (2)
Brandt, Ingvar (2)
Brunström, Björn (2)
Ilbäck, Nils-Gunnar (2)
Risérus, Ulf (2)
Breitholtz, Magnus (2)
Lynch, I (2)
Hellman, Per (2)
Westerholm, Roger (2)
Spjuth, Ola, Docent, ... (2)
Vahter, M (2)
Raqib, Rubhana (2)
Bergvall, Christoffe ... (2)
Fadeel, Bengt (2)
Bauden, Monika (2)
Glynn, Anders (2)
Andersson, Patrik L (2)
Stenius, Ulla (2)
Melhus, Håkan (2)
Bornehag, Carl-Gusta ... (2)
Fadeel, B (2)
Håkansson, Helen (2)
Larsson, Maria, 1975 ... (2)
Engwall, Magnus, 196 ... (2)
Karlsson, Hanna L. (2)
Björklund, Peyman (2)
visa färre...
Lärosäte
Karolinska Institutet (60)
Kungliga Tekniska Högskolan (44)
Uppsala universitet (41)
Sveriges Lantbruksuniversitet (22)
Örebro universitet (18)
Lunds universitet (18)
visa fler...
Umeå universitet (17)
Stockholms universitet (16)
Linköpings universitet (4)
Högskolan Kristianstad (2)
Södertörns högskola (2)
Karlstads universitet (2)
Göteborgs universitet (1)
Högskolan i Halmstad (1)
Högskolan Väst (1)
RISE (1)
visa färre...
Språk
Engelska (194)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (92)
Naturvetenskap (44)
Lantbruksvetenskap (14)
Humaniora (8)
Teknik (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy