| 1. |
- Björck, Lena, 1959, et al.
(författare)
-
Body mass index in women aged 18 to 45 and subsequent risk of heart failure.
- 2020
-
Ingår i: European journal of preventive cardiology. - : Oxford University Press (OUP). - 2047-4881 .- 2047-4873. ; 27:11, s. 1165-1174
-
Tidskriftsartikel (refereegranskat)abstract
- The incidence of heart failure (HF) is decreasing in older ages, but increasing rates have been observed among younger persons in Sweden. Therefore, we investigated the relationship between risk of hospitalization for HF and body mass index (BMI).This was a prospective registry-based cohort study. We included 1,374,031 women aged 18-45 years (mean age 27.9 years) who gave birth during 1982-2014, and were registered in the Medical Birth Register. Information on hospitalization because of HF was collected through linkage to the National Inpatient Register.Compared to women with a BMI of 20-<22.5kg/m2, women with a BMI of 22.5-<25.0 had a hazard ratio (HR) of 1.24 (95% confidence interval (CI), 1.10-1.39) for HF after adjustment for age, year, parity, baseline disorders, smoking, and education. The HR (95% CI) increased to 1.56 (1.36-1.78), 2.39 (2.05-2.78), 2.82 (2.43-3.28), and 4.51 (3.63-5.61) in women with a BMI of 25-<27.5, 27.5-<30, 30-<35, and ≥35kg/m2, respectively. The multiple-adjusted HRs (95% CI) associated with risk of HF per one-unit increase in BMI in women with a BMI≥22.5kg/m2 ranged from 1.01 (0.97-1.06) for HF related to valvular disease to 1.14 (1.12-1.15) for coronary heart disease, diabetes, or hypertension.Increasing body weight was strongly associated with the risk of early HF in women. Compared with lean women, the risk for HF started to increase at high-normal BMI levels, and was nearly five-fold in women with a BMI≥35kg/m2.
|
|
| 2. |
- Dikaiou, Pigi, et al.
(författare)
-
Obesity, overweight and risk for cardiovascular disease and mortality in young women
- 2021
-
Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 28:12, s. 1351-1359
-
Tidskriftsartikel (refereegranskat)abstract
- Aims The aim of this study was to investigate the relation between body mass index (BMI) in young women, using weight early in pregnancy as a proxy for pre-pregnancy weight, and risk for early cardiovascular disease (CVD) and mortality. Methods and results In this prospective, registry-based study, we used weight data in early pregnancy from women, registered in the Swedish Medical Birth Registry, and who gave birth between 1982 and 2014 (n = 1,495,499; median age 28.3 years). Of the women, 118,212 (7.9%) were obese (BMI >= 30 kg/m(2)) and 29,630 (2.0%) severely obese (BMI >= 35 kg/m(2)). After a follow-up of median 16.3 years, we identified 3295 and 4375 cases of acute myocardial infarction (AMI) and ischemic stroke (IS) corresponding to 13.4 and 17.8 per 100,000 observation years, respectively, occurring at mean ages of 49.8 and 47.3 years. Compared to women with a BMI 20-<22.5 kg/m(2), the hazard ratio (HR) of AMI increased with higher BMI from 1.40 (95% confidence interval (CI) 1.27-1.54) among women with BMI 22.5-<25.0 kg/m(2) to 4.71 (95% CI 3.88-5.72) among women with severe obesity, with similar findings for IS and CVD death, after adjustment for age, pregnancy year, parity and comorbidities at baseline. Women with BMI 30-<35.0 and >= 35 kg/m(2) had increased all-cause mortality with adjusted HR 1.53 (95% CI 1.43-1.63) and 1.83 (95% CI 1.63-2.05), respectively. Conclusion A significant increase in the risk for early AMI, IS and CVD death was noticeable in overweight young women, with a marked increase in obese women.
|
|
| 3. |
- Karjalainen, Tina, et al.
(författare)
-
An evaluation of the performance of SCORE Sweden 2015 in estimating cardiovascular risk : The Northern Sweden MONICA Study 1999-2014
- 2017
-
Ingår i: European Journal of Preventive Cardiology. - : Sage Publications. - 2047-4873 .- 2047-4881. ; 24:1, s. 103-110
-
Tidskriftsartikel (refereegranskat)abstract
- Background Risk prediction models for cardiovascular death are important for providing advice on lifestyle and in decision-making regarding primary preventive drug treatment. The latest Swedish version of the Systematic COronary Risk Evaluation (SCORE 2015) has yet not been tested in the population. Objective The objective of this study was to estimate the prevalence of high and very high risk of fatal cardiovascular disease (CVD) of the current population according to 2015 SCORE Sweden and to evaluate the predictive accuracy of the 2003 Swedish version of SCORE (2003 SCORE Sweden) and 2015 SCORE Sweden in a population with declining CVD mortality. Methods We estimated the high and very high risk group for cardiovascular death for individuals 40-65 years of age in the 2014 Northern Sweden MONICA population survey excluding subjects with known diabetes or previous CVD (n=813). Using the 1999 MONICA survey (n=3347) followed up for 10 years for CVD mortality, we assessed the calibration of both 2003 and 2015 SCORE Sweden. Results In 2014 2.6% of the population was considered at high or very high risk for fatal CVD, 95% were men and 76% were in the age group 60-65 years. Including subjects with a single markedly elevated risk factor, known diabetes or CVD, 12% of the population was at high or very high risk. During 10 years of follow-up of the 1999 cohort, 34 CVD deaths (24 men and 10 women) occurred. The 2003 SCORE overestimated the risk of death from CVD (ratio predicted/observed 2.3, P<0.001) whereas the 2015 SCORE slightly overestimated the number of deaths (predicted/observed 1.3, P=0.12). The 2015 SCORE predicted more accurately than the 2003 SCORE the number of deaths in the different risk and age categories. Conclusion The 2015 SCORE Sweden more adequately than 2003 SCORE Sweden predicts the number of deaths. In 2014, the proportion of high-risk individuals is small in northern Sweden. The main use of 2015 SCORE Sweden would therefore be as an educational tool between the physician and people without diabetes or CVD in a consultation regarding cardiovascular risk.
|
|
| 4. |
- Mourtzinis, Georgios, 1974, et al.
(författare)
-
Primary aldosteronism and thyroid disorders in atrial fibrillation: A Swedish nationwide case-control study
- 2018
-
Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 25:7, s. 694-701
-
Tidskriftsartikel (refereegranskat)abstract
- Background Atrial fibrillation is associated with hyperthyroidism. Patients with primary aldosteronism have an increased prevalence of atrial fibrillation. However, the prevalence of primary aldosteronism in the atrial fibrillation population is unknown. Aim This nationwide case-control study aimed to compare the prevalence of primary aldosteronism and thyroid disorders in patients with atrial fibrillation with that of age- and sex-matched controls. Methods We identified all atrial fibrillation cases in Sweden between 1987 and 2013 (n=713,569) by using the Swedish National Patient Register. A control cohort without atrial fibrillation was randomly selected from the Swedish Total Population Register with a case to control ratio of 1:2. This control cohort was matched for age, sex and place of birth (n=1,393,953). Results The prevalence of primary aldosteronism in December 2013 was 0.056% in the atrial fibrillation cohort and 0.024% in controls. At the same time, the prevalence of hypothyroidism was 5.9% in the atrial fibrillation cohort and 3.7% in controls. The prevalence of hyperthyroidism was 2.3% in the atrial fibrillation cohort and 0.8% in controls. Conclusion This study shows, for the first time, a doubled prevalence of primary aldosteronism in a large cohort of patients with atrial fibrillation compared with the general population. There is also an increased prevalence of hypo- and hyper-thyroidism in patients with atrial fibrillation compared with the general population.
|
|
| 5. |
- Persson, Christina, 1985, et al.
(författare)
-
Young women, body size and risk of atrial fibrillation.
- 2018
-
Ingår i: European journal of preventive cardiology. - : Oxford University Press (OUP). - 2047-4881 .- 2047-4873. ; 25:2, s. 173-180
-
Tidskriftsartikel (refereegranskat)abstract
- Background A large body size in early adult life has been associated with an increased risk of atrial fibrillation (AF) later in life in men; however, this has not yet been investigated in women.Prospective cohort study.We included all women in the Swedish Medical Birth Registry with known weight and height from 1982 to 2014. The main exposure body surface area (BSA) was calculated as the square root of (height [cm] × weight [kg]/3600). Information on hospital diagnoses of AF were obtained from the Patient Registry. The study population comprised 1,522,329 women (mean age 28.3 years).A total of 6993 women (0.5%) were diagnosed with AF during a maximum follow-up of 33.6 years (mean 16.6 years, confidence interval [CI] 16.6-16.6). Risk of AF rose linearly with increasing BSA, body mass index (BMI) and height, with up to a threefold increased risk in the biggest women. Hazard ratios associated with BSA were 1.21 (95% CI 1.12-1.30), 1.45 (95% CI 1.35-1.56) and 2.11 (95% CI 1.97-2.26) when comparing the second, third and fourth quartiles, respectively, with the first. The elevated risk persisted after stratifying for different levels of BMI, even among women with low-normal BMI. Conclusion A larger body size measured early in adulthood was, independent from BMI, associated with an increased risk of AF in women during follow-up of up to 33 years.
|
|
| 6. |
- Royer, Patrick, et al.
(författare)
-
Large-scale plasma proteomics in the UK Biobank modestly improves prediction of major cardiovascular events in a population without previous cardiovascular disease
- 2024
-
Ingår i: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY. - 2047-4873 .- 2047-4881.
-
Tidskriftsartikel (refereegranskat)abstract
- [ ' A i m s I m p r o v e d i d e n t i f i c a t i o n o f i n d i v i d u a l s a t h i g h r i s k o f d e v e l o p i n g c a r d i o v a s c u l a r d i s e a s e w o u l d e n a b l e t a r g e t e d i n t e r v e n t i o n s a n d p o t e n t i a l l y l e a d t o r e d u c t i o n s i n m o r t a l i t y a n d m o r b i d i t y . O u r a i m w a s t o d e t e r m i n e w h e t h e r u s e o f l a r g e - s c a l e p r o t e o m i c s i m p r o v e s p r e d i c t i o n o f c a r d i o v a s c u l a r e v e n t s b e y o n d t r a d i t i o n a l r i s k f a c t o r s ( T R F s ) . M e t h o d s a n d r e s u l t s U s i n g p r o x i m i t y e x t e n s i o n a s s a y s , 2 9 1 9 p l a s m a p r o t e i n s w e r e m e a s u r e d i n 3 8 3 8 0 p a r t i c i p a n t s o f t h e U K B i o b a n k . B o t h d a t a - a n d l i t e r a t u r e - b a s e d f e a t u r e s e l e c t i o n a n d t r a i n e d m o d e l s u s i n g e x t r e m e g r a d i e n t b o o s t i n g m a c h i n e l e a r n i n g w e r e u s e d t o p r e d i c t r i s k o f m a j o r c a r d i o v a s c u l a r e v e n t s ( M A C E s : f a t a l a n d n o n - f a t a l m y o c a r d i a l i n f a r c t i o n , s t r o k e , a n d c o r o n a r y a r t e r y r e v a s c u l a r i z a t i o n ) d u r i n g a 1 0 - y e a r f o l l o w - u p . A r e a u n d e r t h e c u r v e ( A U C ) a n d n e t r e c l a s s i f i c a t i o n i n d e x ( N R I ) w e r e u s e d t o e v a l u a t e t h e a d d i t i v e v a l u e o f s e l e c t e d p r o t e i n p a n e l s t o M A C E p r e d i c t i o n b y S y s t e m a t i c C O r o n a r y R i s k E v a l u a t i o n 2 ( S C O R E 2 ) o r t h e 1 0 T R F s u s e d i n S C O R E 2 . S C O R E 2 a n d S C O R E 2 r e f i t t e d t o U K B i o b a n k d a t a p r e d i c t e d M A C E w i t h A U C s o f 0 . 7 4 0 a n d 0 . 7 4 9 , r e s p e c t i v e l y . D a t a - d r i v e n s e l e c t i o n i d e n t i f i e d 1 1 4 p r o t e i n s o f g r e a t e s t r e l e v a n c e f o r p r e d i c t i o n . P r e d i c t i o n o f M A C E w a s n o t i m p r o v e d b y u s i n g t h e s e p r o t e i n s a l o n e ( A U C o f 0 . 7 5 8 ) b u t w a s s i g n i f i c a n t l y i m p r o v e d b y c o m b i n i n g t h e s e p r o t e i n s w i t h S C O R E 2 o r t h e 1 0 T R F s ( A U C = 0 . 7 7 1 , P < 0 0 1 , N R I = 0 . 1 4 0 , a n d A U C = 0 . 7 6 7 , P = 0 . 0 3 , N R I 0 . 0 5 3 , r e s p e c t i v e l y ) . L i t e r a t u r e - b a s e d p r o t e i n s e l e c t i o n ( 1 1 3 p r o t e i n s f r o m f i v e p r e v i o u s s t u d i e s ) a l s o i m p r o v e d r i s k p r e d i c t i o n b e y o n d T R F s w h i l e a r a n d o m s e l e c t i o n o f 1 1 4 p r o t e i n s d i d n o t . C o n c l u s i o n L a r g e - s c a l e p l a s m a p r o t e o m i c s w i t h d a t a - d r i v e n a n d l i t e r a t u r e - b a s e d p r o t e i n s e l e c t i o n m o d e s t l y i m p r o v e s p r e d i c t i o n o f f u t u r e M A C E b e y o n d T R F s . L a y s u m m a r y T h e r i s k o f h a v i n g a m y o c a r d i a l i n f a r c t i o n o r s t r o k e i s u s u a l l y a s s e s s e d b y c l i n i c a l s c o r e s i n c l u d i n g t r a d i t i o n a l r i s k f a c t o r s f o r c a r d i o v a s c u l a r d i s e a s e . T h e d e v e l o p m e n t o f n e w t e c h n o l o g i e s e n a b l e s t h e r a p i d m e a s u r e m e n t o f a n i n c r e a s i n g n u m b e r o f b l o o d p r o t e i n s . I n t h i s s t u d y , w e a p p l i e d m a c h i n e l e a r n i n g t e c h n i q u e s i n a U K - b a s e d c o h o r t o f 3 8 3 8 0 p a r t i c i p a n t s w i t h 2 9 1 9 b l o o d p r o t e i n s m e a s u r e d . W e o b t a i n e d a s e t o f 1 1 4 p r o t e i n s t h a t i m p r o v e d t h e p r e d i c t i o n o f t h e 1 0 - y e a r r i s k o f m a j o r c a r d i o v a s c u l a r e v e n t w h e n a d d e d t o t r a d i t i o n a l r i s k f a c t o r s . I m p r o v e m e n t s w e r e a l s o a c h i e v e d u s i n g a s e t o f 1 1 3 p r o t e i n s f o u n d i n p r e v i o u s s t u d i e s . H o w e v e r , t h e m a g n i t u d e o f t h e s e i m p r o v e m e n t s w a s r e l a t i v e l y l o w a n d t h e c l i n i c a l u t i l i t y o f c o m b i n i n g t h e s e p r o t e i n s w i t h t r a d i t i o n a l r i s k f a c t o r s i n p r i m a r y p r e v e n t i o n w i l l h a v e t o b e f u r t h e r i n v e s t i g a t e d . ' , ' [ G R A P H I C S ] ' , ' . ' ]
|
|
