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Islet amyloid depos...
Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets.
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- Ullsten, Sara (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Uppsala University, Sweden
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- Bohman, Sara (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Uppsala University, Sweden
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- Oskarsson, Marie E (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Uppsala University, Sweden
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- Nilsson, Peter (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Westermark, Gunilla (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Uppsala University, Sweden
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- Carlsson, Per-Ola (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin,Uppsala University, Sweden
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(creator_code:org_t)
- BIOSCIENTIFICA LTD, 2017
- 2017
- Engelska.
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Ingår i: Endocrine Connections. - : BIOSCIENTIFICA LTD. - 2049-3614. ; 6:7, s. 458-468
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Islet amyloid and beta cell death in type 2 diabetes are heterogeneous events, where some islets are affected early in the disease process, whereas others remain visibly unaffected. This study investigated the possibility that inter-islet functional and vascular differences may explain the propensity for amyloid accumulation in certain islets. Highly blood-perfused islets were identified by microspheres in human islet amyloid polypeptide expressing mice fed a high-fat diet for three or 10 months. These highly blood-perfused islets had better glucose-stimulated insulin secretion capacity than other islets and developed more amyloid deposits after 10 months of high-fat diet. Similarly, human islets with a superior release capacity formed more amyloid in high glucose culture than islets with a lower release capacity. The amyloid formation in mouse islets was associated with a higher amount of prohormone convertase 1/3 and with a decreased expression of its inhibitor proSAAS when compared to islets with less amyloid. In contrast, levels of prohormone convertase 2 and expression of its inhibitor neuroendocrine protein 7B2 were unaltered. A misbalance in prohormone convertase levels may interrupt the normal processing of islet amyloid polypeptide and induce amyloid formation. Preferential amyloid load in the most blood-perfused and functional islets may accelerate the progression of type 2 diabetes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- blood flow
- heterogeneity
- islet amyloid
- pancreatic islets
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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