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Träfflista för sökning "L773:0001 6268 ;lar1:(uu);srt2:(1990-1994)"

Sökning: L773:0001 6268 > Uppsala universitet > (1990-1994)

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1.
  • Schürer, L, et al. (författare)
  • Leucocyte depletion does not affect post-ischaemic nerve cell damage in the rat.
  • 1991
  • Ingår i: Acta Neurochirurgica. - 0001-6268 .- 0942-0940. ; 111:1-2, s. 54-60
  • Tidskriftsartikel (refereegranskat)abstract
    • Leucocytes play an important role in inflammation and immunologic responses. They might be of special significance under pathophysiological conditions of the brain i.e. ischaemia or stroke. It has been shown that neutropenic animals undergoing reversible ischaemia show higher post-ischaemic blood flow, suggesting improved post-ischaemic perfusion. In this study it was investigated therefore, whether polymorphonuclear leucocytes contribute to the nerve cell loss in the hippocampus after a reversible period of ischaemia. Rats were made neutropenic with a specific anti-serum against rat polymorphonuclear leucocytes yielding leucocyte counts less than 10% of normal. The animals were then subjected to 15 min reversible forebrain ischaemia. Quantitative histology was performed after a survival period of 7 days. Nerve cell counts in the frontal cortex and in the CA1 and CA3 sectors of the hippocampus did not reveal any differences between neutropenic rats and animals with normal leucocyte counts. From the results it might be concluded that neutrophils do not significantly contribute to the selective post-ischaemic nerve cell damage in the rat.
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2.
  • Schürer, L, et al. (författare)
  • Superoxide dismutase does not prevent delayed hypoperfusion after incomplete cerebral ischaemia in the rat.
  • 1990
  • Ingår i: Acta Neurochirurgica. - 0001-6268 .- 0942-0940. ; 103:3-4, s. 163-70
  • Tidskriftsartikel (refereegranskat)abstract
    • Local cerebral blood flow (1CBF) was measured autoradiographically 60 minutes after 15 minutes of forebrain ischaemia in rats treated with superoxide dismutase (SOD) before (50 mg.kg-1 body weight) or at the end of the ischaemia period (4 mg.kg-1 body weight). Incomplete forebrain ischaemia was produced by a combination of common carotid artery occlusion and bleeding to a mean arterial blood pressure of 50 mmHg. During ischaemia the 1CBF values in cortical areas were less than 3% of the preischaemic values and treatment with SOD prior to ischaemia did not influence 1CBF during ischaemia. Sixty minutes after termination of cerebral ischaemia the 1CBF values were decreased to between 40 and 60% of values found in control animals. Neither form of treatment improved the postischaemic cerebral blood flows. The results imply that postischaemic flow disturbances in the brain may not be due to extracellular superoxide production.
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  • Resultat 1-2 av 2
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tidskriftsartikel (2)
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refereegranskat (2)
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Gerdin, Bengt, 1947- (2)
Arfors, K.-E. (2)
Grøgaard, B (2)
Schürer, L (2)
Kempski, O (1)
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Uppsala universitet  (2)Ta bort avgränsningen
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Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)

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