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Träfflista för sökning "L773:0092 8674 OR L773:1097 4172 srt2:(1995-1999)"

Sökning: L773:0092 8674 OR L773:1097 4172 > (1995-1999)

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1.
  • Hurme, R, et al. (författare)
  • A proteinaceous gene regulatory thermometer in Salmonella
  • 1997
  • Ingår i: Cell. - 0092-8674 .- 1097-4172. ; 90:1, s. 55-64
  • Tidskriftsartikel (refereegranskat)abstract
    • Novel utilization of the coiled-coil motif is presented that enables TlpA, an autoregulatory repressor protein in Salmonella, to sense temperature shifts directly and thereby to modulate the extent of transcription repression. Salmonella cells shifted to higher temperatures, such as those encountered at host entry, showed derepressed tlpA activity. tlpA::lacZ fusions indicated that the promoter itself is insensitive to thermal shifts and that transcription control was exerted by the autorepressor TlpA only. In vitro studies with highly purified TlpA showed concentration and temperature dependence for both fully folded conformation and function, indicating that the thermosensing in TlpA is based on monomer-to-coiled-coil equilibrium.
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  • Boström, Hans, et al. (författare)
  • PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis.
  • 1996
  • Ingår i: Cell. - : Elsevier BV. - 0092-8674. ; 85:6, s. 863-73
  • Tidskriftsartikel (refereegranskat)abstract
    • A mouse platelet-derived growth factor A chain (PDGF-A) null allele is shown to be homozygous lethal, with two distinct restriction points, one prenatally before E10 and one postnatally. Postnatally surviving PDGF-A-deficient mice develop lung emphysema secondary to the failure of alveolar septation. This is apparently caused by the loss of alveolar myofibroblasts and associated elastin fiber deposits. PDGF alpha receptor-positive cells in the lung having the location of putative alveolar myofibroblast progenitors were specifically absent in PDGF-A null mutants. We conclude that PDGF-A is crucial for alveolar myofibroblast ontogeny. We have previously shown that PDGF-B is required in the ontogeny of kidney mesangial cells. The PDGFs therefore appear to regulate the generation of specific populations of myofibroblasts during mammalian development. The two PDGF null phenotypes also reveal analogous morphogenetic functions for myofibroblast-type cells in lung and kidney organogenesis.
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