| 1. |
- Enblad, P, et al.
(författare)
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Comparative immunohistochemical demonstration of difucosylated carbohydrate antigens and CEA in adenomas and carcinomas of the rectum and rectosigmoid
- 1986
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Ingår i: Anticancer research. - 1791-7530. ; 6:2, s. 139-146
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Tidskriftsartikel (refereegranskat)abstract
- The present immunohistochemical investigation reveals that difucosylated carbohydrate antigens (DFCA) are extensively expressed in rectal and rectosigmoid carcinomas while normal mucosa and hyperplastic polyps are mainly negative. The adenomas showed intermediate staining patterns where adenomas with villous structures and moderate-severe dysplasia resembled of carcinomas. CEA was more extensively expressed in both normal, premalignant, and malignant tissue. Thus, DFCA is better than CEA as a discriminator between normal and malignant tissue in the distal large bowel, and may be used in future studies with the intention of advancing our understanding of the neoplastic process and assessing clinical relevance.
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| 2. |
- Flodgren, P, et al.
(författare)
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Immune functions in melanoma patients during treatment with interferon [HuIFN-alpha (Le)] alone or in combination with cimetidine
- 1985
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Ingår i: Anticancer research. - 0250-7005. ; 5:2, s. 197-204
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Tidskriftsartikel (refereegranskat)abstract
- While leukocyte interferon was found therapeutically ineffective in a series of 20 patients with metastatic malignant melanoma, subsequent combination treatment with interferon and cimetidine induced 5 complete and 1 partial tumour remissions. Prior to interferon therapy initiation, regressor patients demonstrated a significantly greater ability to mediate antibody-dependent cellular cytotoxicity than progressor patients and also tended to have higher natural killer-cell activity. These differences were more pronounced following in vitro exposure of effector cells to interferon alone or in combination with cimetidine. During therapy the differences decreased to statistically nonsignificant levels. The number of immunoglobulin producing cells and lymphocyte proliferative responses to Con A were found to increase in both patient groups after interferon therapy initiation; but this augmentation vanished gradually upon combined treatment with cimetidine. A gradual decrease of the number of T lymphocytes and granulocytes was also recorded. None of the demonstrated alterations in the activities of circulating lymphocytes appears to be a relevant correlate to the efficacy of combined therapy compared to interferon alone.
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| 3. |
- Jakobsson, A H, et al.
(författare)
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Chromatin bodies in multidrug resistant hybrid cells have centromeres and originate from homogeneously staining regions.
- 1989
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Ingår i: Anticancer research. - 0250-7005. ; 9:2, s. 267-71
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Tidskriftsartikel (refereegranskat)abstract
- Antikinetochore antibodies from patients with the CREST syndrome of scleroderma were used as probes to study homogeneously staining regions (HSRs) in multidrug resistant (MDR) mouse tumor cells, and chromatin bodies (CBs) in MDR mouse-hamster hybrid cells. In one mouse tumor line the C-band positive HSR showed antigenic properties and displayed many weekly fluorescent spots, i.e. it contained kinetochore proteins. The immunofluorescence pattern of the HSR could also be observed in interphase nuclei. The C-band positive CBs of the hybrid cells had active centromeres, as shown by double kinetochore spots. These results support our hypothesis that CBs originate from C-band positive HSRs.
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| 4. |
- Mattsson, J, et al.
(författare)
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Intratumoral distribution of microspheres.
- 1986
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Ingår i: Anticancer research. - 0250-7005. ; 6:4, s. 563-6
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Tidskriftsartikel (refereegranskat)abstract
- Fifteen mu carbonized microspheres injected in two transplantable rat tumors, a hepatoma transplanted to the dorsum of one hindpaw and an adenocarcinoma transplanted into the liver, were found to be unevenly distributed and often in aggregates that seemed to fill intratumoral vessels. This finding can partly explain the increased vascular resistance in tumors after microsphere injection and makes the technique with repeated injections of microspheres disputable.
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| 5. |
- Olsson, H., et al.
(författare)
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Early oral contraceptive use as a prognostic factor in breast cancer
- 1988
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Ingår i: Anticancer research. - 0250-7005. ; 8:1, s. 29-32
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Tidskriftsartikel (refereegranskat)abstract
- The survival of 193 premenopausal breast cancer patients was investigated in relation to their history of early use of oral contraceptives. The women were born in 1939 or later and diagnosed in the southern health care region of Sweden. Women, who had started their oral contraceptive use (OC-use) before 20 years of age had a significantly lower survival rate as compared with those who had never used OC and late users (p = 0.02 and = 0.04 respectively, generalized Wilcoxon test). For women who started OC-use between 20 to 25 years of age, a tendency for a shorter survival was seen in comparison with women who had never used OC (p = 0.18). For all patients simultaneously, the relative risk adjusted for age at diagnosis increased for earlier OC-start. When only stages II and III were considered in a stratified multivariate model, a signficantly elevated risk was seen for early users of OC irrespective of age or of adjuvant treatment given. The estrogen and progesterone receptor concentrations of the primary tumor were significantly lower among early users (p = 0.001 and p = 0.05 respectively).
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| 6. |
- Olsson, H., et al.
(författare)
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Permanent alterations induced in plasma prolactin and estrogen receptor concentration in benign and malignant tissue of women who started oral contraceptive use at an early age
- 1987
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Ingår i: Anticancer research. - 0250-7005. ; 7:4 B, s. 853-856
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Tidskriftsartikel (refereegranskat)abstract
- In 65 young women undergoing curettage for benign utrine disorders a signicicant relationship was found between early oral contraceptive use (starting age<25 years) and a high ratio of ln plasma prolactin versus ln estrogen receptor concentration of the uterine mucosae (p<0.047, Mann-Whitneys U-test). Year of birth, age at menarche, age at first full term pregnancy, parity, menstrual cycle phase and duration of oral contraceptive use could not explain the results. Because similar results have previously been found for breast cancer patients using plasma prolactin and breast tumour estrogen receptor concentration, the findings indicate that early oral contraceptive use permanently alters plasma prolactin levels and estrogen receptor concentration, both in benign uterine tissue and in malignant breast tumours.
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