| 1. |
- Gustafsson, Britt, et al.
(author)
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Space-time clustering of childhood lymphatic leukaemias and non-Hodgkin's lymphomas in Sweden
- 2000
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In: European Journal of Epidemiology. - 0393-2990 .- 1573-7284. ; 16:12, s. 1111-1116
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Journal article (peer-reviewed)abstract
- Background: The discussion concerning clusters of childhood leukaemia has mainly been focused on their relation to the time and place of diagnosis. Recently some studies have indicated clustering not only at diagnosis, but also around time and place of birth. Space-time clustering at time of birth could be of special interest if the aetiological agent is of infectious origin and the induction of leukaemia either occurs pre- or perinatally or an infection at that time favours a poor subsequent immune response to the agent. Methods: To identify possible space-time clustering we have used the close-pair method of Knox. One-thousand-twenty recorded cases (0-14 years) of childhood acute lymphatic leukaemia and 293 cases (0-14 years) of malignant non-Hodgkin's lymphoma from Sweden between 1973-1996 were analysed. The records include date of birth and of diagnosis as well as addresses at birth and at diagnosis. Results: A significant excess of case-pairs (25 observed, 14.9 expected, p = 0.01) was observed close in date and place of birth in the 4-14 year age group with acute lymphatic leukaemia (ALL). However there was no statistically significant clustering found around time of diagnosis. When the cases of leukaemia and the non-Hodgkin's lymphomas were combined no statistically significant clustering was obtained neither at birth nor at diagnosis. Conclusions: This study strengthens the evidence of space-time clustering around the birth date in children whom later developed ALL. This observation is in support of the hypothesis that pre- or perinatal infections can induce a process leading to ALL.
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| 2. |
- Hassler, Sven, et al.
(author)
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Cancer risk in the reindeer breeding Saami population of Sweden, 1961–1997
- 2001
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In: European Journal of Epidemiology. - 0393-2990 .- 1573-7284. ; 17, s. 969-976
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Journal article (peer-reviewed)abstract
- The Saami people are the natives of northern Scandinavia and the Kola Peninsula. In a cohort of 2033 Swedish reindeer breeding Saamis, the cancer risks between 1961 and 1997 were studied. Intotal, 193 cases of cancer were observed versus 322 expected in the general Swedish population and 249 in a geographically matched reference population of non-Saamis. In comparison to non-Saamis living in the same area, the reindeer breeding Saamis showed astatistically significant lower risk of developing cancerofthe prostate and of malignant lymphoma, whereas the risk of stomach cancer was significantly higher. Although there were no statistically significant changes ofcancer risks over time, temporal trends were indicated towards a decreased risk of cancer in the stomach and the prostate. The results suggest that the explanations ofthe low cancer risk ofthe reindeer breeding Saamis, in relation to the non-Saamis in the same environment, are to be found among lifestyle and/or genetic factors
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| 3. |
- Hassler, Sven, et al.
(author)
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Cancer risk in the reindeer breeding Saami population of Sweden, 1961–1997
- 2001
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In: European Journal of Epidemiology. - 0393-2990 .- 1573-7284. ; 17:10, s. 969-976
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Journal article (peer-reviewed)abstract
- The Saami people are the natives of northern Scandinavia and the Kola Peninsula. In a cohort of 2033 Swedish reindeer breeding Saamis, the cancer risks between 1961 and 1997 were studied. In total, 193 cases of cancer were observed versus 322 expected in the general Swedish population and 249 in a geographically matched reference population of non-Saamis. In comparison to non-Saamis living in the same area, the reindeer breeding Saamis showed a statistically significant lower risk of developing cancer of the prostate and of malignant lymphoma, whereas the risk of stomach cancer was significantly higher. Although there were no statistically significant changes of cancer risks over time, temporal trends were indicated towards a decreased risk of cancer in the stomach and the prostate. The results suggest that the explanations of the low cancer risk of the reindeer breeding Saamis, in relation to the non-Saamis in the same environment, are to be found among lifestyle and/or genetic factors.
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| 4. |
- Hedlund, Ulf, et al.
(author)
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Respiratory symptoms and obstructive lung diseases in iron ore miners : report from the obstructive lung disease in northern Sweden studies.
- 2004
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In: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 19:10, s. 953-958
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Journal article (peer-reviewed)abstract
- This is a population-based study on the prevalence of respiratory symptoms assessed by a mail questionnaire. The objective was to examine if work in an iron mine increased the risk of airway symptoms or obstructive diseases. The exposed group consisted of 114 previous or current male miners. Referents, 2472 males from the province, had never been employed by the mining company or worked as miners. Age, smoking and a family history of asthma were considered as possible confounders. The miners had an increased risk for respiratory symptoms (OR=2.2, 95% CI=1.4-3.1) including recurrent wheeze (OR= 2.4, 95% CI= 1.5-3.9), longstanding cough (OR= 1.8, 95% CI = 1.0-3.2), and for physician-diagnosed chronic bronchitis (OR=2.2, 95% CI= 1.0-4.5). Attacks of shortness of breath and asthma manifestations were similar between miners and referents. Higher risks in miners were found particularly among the non-smokers for physician-diagnosed chronic bronchitis (OR=9.2, 95% CI= 3.0-28) and for symptoms as well. A family history of asthma was less common among miners (9.2% vs. 17%, p < 0.05). We conclude that miners in a modern underground iron mine had an increased risk of respiratory symptoms. In contrast to other studies, this increased risk was particularly found in nonsmokers. A family history of asthma may be an important confounder in occupational studies of respiratory diseases.
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| 5. |
- Kristjansson, I, et al.
(author)
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Assessment of aluminium in human deciduous teeth
- 2000
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In: European Journal of Epidemiology. - 0393-2990 .- 1573-7284. ; 16:3, s. 231-233
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Journal article (peer-reviewed)abstract
- The possible role of environmental aluminium exposure in the pathogenesis of various diseases has highlighted the need for methods by which the long-term exposure to aluminium can be assessed. Therefore, we have further developed a method to determine aluminium in human deciduous teeth and applied this method for studying populations in Sweden, Crete and Iceland.
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| 7. |
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| 8. |
- Ruigomez, A, et al.
(author)
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Gender and drug treatment as determinants of mortality in a cohort of heart failure patients
- 2001
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In: European Journal of Epidemiology. - 0393-2990 .- 1573-7284. ; 17:4, s. 329-335
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Journal article (peer-reviewed)abstract
- Aim: We assessed gender differences in the risk of mortality in heart failure (HF) patients and evaluated the association between HF drug treatment and mortality. Methods and Results: We identified a cohort of 820 patients with newly diagnosed HF in 1996 in UK general practices. The diagnosis of HF was confirmed by the general practitioner. Fifty per cent were females and 27% were less than 70 years old. During a mean follow-up of 2 years, 172 patients died. We used computerized records to assess risk factors and drugs prescribed as treatment. The information on severity was assessed through a questionnaire. We performed a nested case–control analysis, and observed that men had twice the risk of dying than females, however the effect of age on mortality was stronger in females than males. We found a similar interaction between HF severity and sex. Data on use of some cardiovascular drugs such as diuretics, beta-blockers ACE-inhibitors and calcium channel blockers were suggestive of a reduced mortality risk. Current use of nitrates and glycosides carried an increased risk. Conclusion: Older age, male sex and severity of HF were the main predictors of mortality among HF patients. Long-term use of beta-blockers was associated with a significantly reduced risk of mortality.
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| 9. |
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| 10. |
- Adami, HO, et al.
(author)
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Miettinen's epidemiology: quo vadis?
- 2004
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In: European journal of epidemiology. - : Springer Science and Business Media LLC. - 0393-2990. ; 19:8, s. 737-739
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Journal article (peer-reviewed)
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