| 1. |
- Memedi, Mevludin, 1983-, et al.
(författare)
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Automatic Spiral Analysis for Objective Assessment of Motor Symptoms in Parkinson's Disease
- 2015
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Ingår i: Sensors. - : MDPI AG. - 1424-8220. ; 15:9, s. 23727-23744
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Tidskriftsartikel (refereegranskat)abstract
- A challenge for the clinical management of advanced Parkinson's disease (PD) patients is the emergence of fluctuations in motor performance, which represents a significant source of disability during activities of daily living of the patients. There is a lack of objective measurement of treatment effects for in-clinic and at-home use that can provide an overview of the treatment response. The objective of this paper was to develop a method for objective quantification of advanced PD motor symptoms related to off episodes and peak dose dyskinesia, using spiral data gathered by a touch screen telemetry device. More specifically, the aim was to objectively characterize motor symptoms (bradykinesia and dyskinesia), to help in automating the process of visual interpretation of movement anomalies in spirals as rated by movement disorder specialists. Digitized upper limb movement data of 65 advanced PD patients and 10 healthy (HE) subjects were recorded as they performed spiral drawing tasks on a touch screen device in their home environment settings. Several spatiotemporal features were extracted from the time series and used as inputs to machine learning methods. The methods were validated against ratings on animated spirals scored by four movement disorder specialists who visually assessed a set of kinematic features and the motor symptom. The ability of the method to discriminate between PD patients and HE subjects and the test-retest reliability of the computed scores were also evaluated. Computed scores correlated well with mean visual ratings of individual kinematic features. The best performing classifier (Multilayer Perceptron) classified the motor symptom (bradykinesia or dyskinesia) with an accuracy of 84% and area under the receiver operating characteristics curve of 0.86 in relation to visual classifications of the raters. In addition, the method provided high discriminating power when distinguishing between PD patients and HE subjects as well as had good test-retest reliability. This study demonstrated the potential of using digital spiral analysis for objective quantification of PD-specific and/or treatment-induced motor symptoms.
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| 2. |
- Jia, Tao, 1983-, et al.
(författare)
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An empirical study on human mobility and its agent-based modeling
- 2012
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Ingår i: Journal of Statistical Mechanics. - Bristol : Institute of Physics Publishing (IOPP). - 1742-5468.
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Tidskriftsartikel (refereegranskat)abstract
- This paper aims to analyze the GPS traces of 258 volunteers for a better understanding of both the human mobility patterns and the mechanism. We report the regular and scaling properties of human mobility from several aspects, and importantly we find its levy flight characteristic which is consistent with the previous studies. We further assume two factors that may govern the levy flight property: (1) the scaling and hierarchical properties of the purpose clusters which serve as the underlying spatial structure, and (2) the individual preferential behavior. To verify the assumptions, we implement an agent-based model with the two factors, and the simulated agents indeed reproduce the same levy flight pattern as the observed one. In order to enable the model to reproduce more mobility patterns, we add the model a third factor, the jumping factor which means the probability that one person may cancel the regular mobility schedule and visit a random place. With this factor, our model could cover a relatively wide range of human mobility patterns with exponent values from 1.55 to 2.05.
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| 3. |
- Kännaste, Astrid, et al.
(författare)
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Odors of Norway spruce (Picea abies L.) seedlings : differences due to age and chemotype
- 2013
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Ingår i: Trees. - : Springer. - 0931-1890 .- 1432-2285. ; 27, s. 149-159
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Tidskriftsartikel (refereegranskat)abstract
- Small conifer seedlings (mini-seedlings) are less damaged by the large pine weevil Hylobius abietis (L.) (Coleoptera: Curculionidae) compared to conventional seedlings. Chemical difference between the seedling types is one possible explanation for this phenomenon. In the present paper, the emissions of volatile organic compounds (VOC) of 7- to 43-week-old Norway spruce [Picea abies (L.) Karst.] seedlings were analyzed. Collection and identification of the volatiles was made by solid phase micro-extraction and gas chromatography mass spectrometry (SPME–GC–MS). The enantiomers of α-pinene and limonene were separated in a two-dimensional GC (2D-GC). Most of the seedlings represented either a limonene- or a bornyl acetate-chemotype. Only minor changes in the volatile composition of the two types of seedlings were found during the first year. Age-related changes, however, were found in the volatiles released by wounded phloem where green leaf volatiles (GLVs) and borneol were the dominated VOC for young seedling. The attractive compound for the pine weevil, α-pinene, was first detected in the phloem emissions of 18- to 22-week-old seedlings. Different storage conditions of the seedlings during the winter/early spring-phase influenced the volatile composition in the phloem. High amount of GLVs was characteristic for the 43-week-old seedlings stored in naturally changing outdoor temperature, but not present in the seedlings winter-stored at a constant temperature of −4 °C. The possible role of these observed differences in odor emissions between seedlings of different age and physiological status for the feeding preferences of the large pine weevil is discussed.
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| 4. |
- Nelson, Ronald, et al.
(författare)
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Genetics of Interactive Behavior in Silver Foxes (Vulpes vulpes)
- 2017
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Ingår i: Behavior Genetics. - : Springer Science and Business Media LLC. - 0001-8244 .- 1573-3297. ; 47:1, s. 88-101
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Tidskriftsartikel (refereegranskat)abstract
- Individuals involved in a social interaction exhibit different behavioral traits that, in combination, form the individual's behavioral responses. Selectively bred strains of silver foxes (Vulpes vulpes) demonstrate markedly different behaviors in their response to humans. To identify the genetic basis of these behavioral differences we constructed a large F2 population including 537 individuals by cross-breeding tame and aggressive fox strains. 98 fox behavioral traits were recorded during social interaction with a human experimenter in a standard four-step test. Patterns of fox behaviors during the test were evaluated using principal component (PC) analysis. Genetic mapping identified eight unique significant and suggestive QTL. Mapping results for the PC phenotypes from different test steps showed little overlap suggesting that different QTL are involved in regulation of behaviors exhibited in different behavioral contexts. Many individual behavioral traits mapped to the same genomic regions as PC phenotypes. This provides additional information about specific behaviors regulated by these loci. Further, three pairs of epistatic loci were also identified for PC phenotypes suggesting more complex genetic architecture of the behavioral differences between the two strains than what has previously been observed.
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| 5. |
- Säfvenberg, Rasmus, 1998-, et al.
(författare)
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The Importance of Special Teams in Ice Hockey
- 2023
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Ingår i: Proceedings of the Linköping Hockey Analytics Conference LINHAC 2023 Research Track. - Linköping, Sweden : Linköping University Electronic Press. ; , s. 53-65
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Konferensbidrag (refereegranskat)abstract
- This paper explores the significance of special teams, particularlypowerplay, in ice hockey. Despite the commonly held perception oftheir importance, little research has examined the impact of powerplayand penalty kill performance on overall team success. The paper usesseveral seasons of NHL data to characterize goal-scoring and manpoweropportunities, and perform analysis from several perspectives. The resultsindicate that individual even strength goals and powerplay goalshave similar value, but the larger share of even strength goals scoredover a season makes even strength play a more important contributorto team success. The paper also finds a high correlation between teamsthat perform above/below average during even strength and powerplay.This study provides valuable insights into the dynamics of ice hockeygameplay and the role of special teams in determining team success.
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| 6. |
- Nelson, Ronald, et al.
(författare)
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MAPfastR : Quantitative trait loci mapping in outbred line crosses
- 2013
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Ingår i: G3. - : Oxford University Press (OUP). - 2160-1836. ; 3, s. 2147-2149
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Tidskriftsartikel (refereegranskat)abstract
- MAPfastR is a software package developed to analyze quantitative trait loci data from inbred and outbred line-crosses. The package includes a number of modules for fast and accurate quantitative trait loci analyses. It has been developed in the R language for fast and comprehensive analyses of large datasets. MAPfastR is freely available at: http://www.computationalgenetics.se/?page_id=7
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| 7. |
- Abdollahi, S., et al.
(författare)
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Fermi Large Area Telescope Fourth Source Catalog
- 2020
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Ingår i: Astrophysical Journal Supplement Series. - : American Astronomical Society. - 0067-0049 .- 1538-4365. ; 247:1
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Tidskriftsartikel (refereegranskat)abstract
- We present the fourth Fermi Large Area Telescope catalog (4FGL) of gamma-ray sources. Based on the first eight years of science data from the Fermi Gamma-ray Space Telescope mission in the energy range from 50 MeV to 1 TeV, it is the deepest yet in this energy range. Relative to the 3FGL catalog, the 4FGL catalog has twice as much exposure as well as a number of analysis improvements, including an updated model for the Galactic diffuse gamma-ray emission, and two sets of light curves (one-year and two-month intervals). The 4FGL catalog includes 5064 sources above 4 sigma significance, for which we provide localization and spectral properties. Seventy-five sources are modeled explicitly as spatially extended, and overall, 358 sources are considered as identified based on angular extent, periodicity, or correlated variability observed at other wavelengths. For 1336 sources, we have not found plausible counterparts at other wavelengths. More than 3130 of the identified or associated sources are active galaxies of the blazar class, and 239 are pulsars.
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| 8. |
- Aghanavesi, Somayeh, 1981-, et al.
(författare)
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Verification of a Method for Measuring Parkinson's Disease Related Temporal Irregularity in Spiral Drawings
- 2017
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Ingår i: Sensors. - Basel : MDPI AG. - 1424-8220. ; 17:10
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Tidskriftsartikel (refereegranskat)abstract
- -value = 0.02). Test-retest reliability of TIS was good with Intra-class Correlation Coefficient of 0.81. When assessing changes in relation to treatment, TIS contained some information to capture changes from Off to On and wearing off effects. However, the correlations between TIS and clinical scores (UPDRS and Dyskinesia) were weak. TIS was able to differentiate spiral drawings drawn by patients in an advanced stage from those drawn by healthy subjects, and TIS had good test-retest reliability. TIS was somewhat responsive to single-dose levodopa treatment. Since TIS is an upper limb high-frequency-based measure, it cannot be detected during clinical assessment.
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| 9. |
- Jacobsson, Martin, 1976-, et al.
(författare)
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A Drone-mounted Depth Camera-based Motion Capture System for Sports Performance Analysis
- 2023
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Ingår i: Artificial Intelligence in HCI. - : Springer Nature. - 9783031358937 ; , s. 489-503
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Konferensbidrag (refereegranskat)abstract
- Video is the most used tool for sport performance analysis as it provides a common reference point for the coach and the athlete. The problem with video is that it is a subjective tool. To overcome this, motion capture systems can used to get an objective 3D model of a per- son’s posture and motion, but only in laboratory settings. Unfortunately, many activities, such as most outdoor sports, cannot be captured in a lab without compromising the activity. In this paper, we propose to use an aerial drone system equipped with depth cameras, AI-based marker- less motion capture software to perform automatic skeleton tracking and real-time sports performance analysis of athletes. We experiment with off-the-shelf drone systems, miniaturized depth cameras, and commer- cially available skeleton tracking software to build a system for analyzing sports-related performance of athletes in their real settings. To make this a fully working system, we have conducted a few initial experiments and identified many issues that still needs to be addressed.
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| 10. |
- Lankinen, Åsa, et al.
(författare)
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Pollen-tube growth rates in Collinsia heterophylla (Plantaginaceae) : one-donor crosses reveal heritability but no effect on sporophytic-offspring fitness
- 2009
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Ingår i: Annals of Botany. - : Oxford University Press (OUP). - 0305-7364 .- 1095-8290. ; 103:6, s. 941-950
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Tidskriftsartikel (refereegranskat)abstract
- Evolutionary change in response to natural selection will occur only if a trait confers a selective advantage and there is heritable variation. Positive connections between pollen traits and fitness have been found, but few studies of heritability have been conducted, and they have yielded conflicting results. To understand better the evolutionary significance of pollen competition and its potential role in sexual selection, the heritability of pollen tube-growth rate and the relationship between this trait and sporophytic offspring fitness were investigated in Collinsia heterophylla. Because the question being asked was if female function benefited from obtaining genetically superior fathers by enhancing pollen competition, one-donor (per flower) crosses were used in order to exclude confounding effects of post-fertilization competition/allocation caused by multiple paternity. Each recipient plant was crossed with an average of five pollen donors. Pollen-tube growth rate and sporophytic traits were measured in both generations. Pollen-tube growth rate in vitro differed among donors, and the differences were correlated with in vivo growth rate averaged over two to four maternal plants. Pollen-tube growth rate showed significant narrow-sense heritability and evolvability in a father-offspring regression. However, this pollen trait did not correlate significantly with sporophytic-offspring fitness. These results suggest that pollen-tube growth rate can respond to selection via male function. The data presented here do not provide any support for the hypothesis that intense pollen competition enhances maternal plant fitness through increased paternity by higher-quality sporophytic fathers, although this advantage cannot be ruled out. These data are, however, consistent with the hypothesis that pollen competition is itself selectively advantageous, through both male and female function, by reducing the genetic load among successful gametophytic fathers (pollen), and reducing inbreeding depression associated with self-pollination in plants with mix-mating systems.
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