| 1. |
- Aghanavesi, Somayeh, 1981-, et al.
(författare)
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A multiple motion sensors index for motor state quantification in Parkinson's disease
- 2020
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Ingår i: Computer Methods and Programs in Biomedicine. - : Elsevier BV. - 0169-2607 .- 1872-7565. ; 189
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To construct a Treatment Response Index from Multiple Sensors (TRIMS) for quantification of motor state in patients with Parkinson's disease (PD) during a single levodopa dose. Another aim was to compare TRIMS to sensor indexes derived from individual motor tasks. Method: Nineteen PD patients performed three motor tests including leg agility, pronation-supination movement of hands, and walking in a clinic while wearing inertial measurement unit sensors on their wrists and ankles. They performed the tests repeatedly before and after taking 150% of their individual oral levodopa-carbidopa equivalent morning dose.Three neurologists blinded to treatment status, viewed patients’ videos and rated their motor symptoms, dyskinesia, overall motor state based on selected items of Unified PD Rating Scale (UPDRS) part III, Dyskinesia scale, and Treatment Response Scale (TRS). To build TRIMS, out of initially 178 extracted features from upper- and lower-limbs data, 39 features were selected by stepwise regression method and were used as input to support vector machines to be mapped to mean reference TRS scores using 10-fold cross-validation method. Test-retest reliability, responsiveness to medication, and correlation to TRS as well as other UPDRS items were evaluated for TRIMS. Results: The correlation of TRIMS with TRS was 0.93. TRIMS had good test-retest reliability (ICC = 0.83). Responsiveness of the TRIMS to medication was good compared to TRS indicating its power in capturing the treatment effects. TRIMS was highly correlated to dyskinesia (R = 0.85), bradykinesia (R = 0.84) and gait (R = 0.79) UPDRS items. Correlation of sensor index from the upper-limb to TRS was 0.89. Conclusion: Using the fusion of upper- and lower-limbs sensor data to construct TRIMS provided accurate PD motor states estimation and responsive to treatment. In addition, quantification of upper-limb sensor data during walking test provided strong results. © 2019
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| 2. |
- Aghanavesi, Somayeh, 1981-, et al.
(författare)
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A review of Parkinson’s disease cardinal and dyskinetic motor symptoms assessment methods using sensor systems
- 2016
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Konferensbidrag (refereegranskat)abstract
- This paper is reviewing objective assessments of Parkinson’s disease(PD) motor symptoms, cardinal, and dyskinesia, using sensor systems. It surveys the manifestation of PD symptoms, sensors that were used for their detection, types of signals (measures) as well as their signal processing (data analysis) methods. A summary of this review’s finding is represented in a table including devices (sensors), measures and methods that were used in each reviewed motor symptom assessment study. In the gathered studies among sensors, accelerometers and touch screen devices are the most widely used to detect PD symptoms and among symptoms, bradykinesia and tremor were found to be mostly evaluated. In general, machine learning methods are potentially promising for this. PD is a complex disease that requires continuous monitoring and multidimensional symptom analysis. Combining existing technologies to develop new sensor platforms may assist in assessing the overall symptom profile more accurately to develop useful tools towards supporting better treatment process.
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| 3. |
- Aghanavesi, Somayeh, 1981-
(författare)
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Smartphone-based Parkinson’s disease symptom assessment
- 2017
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis consists of four research papers presenting a microdata analysis approach to assess and evaluate the Parkinson’s disease (PD) motor symptoms using smartphone-based systems. PD is a progressive neurological disorder that is characterized by motor symptoms. It is a complex disease that requires continuous monitoring and multidimensional symptom analysis. Both patients’ perception regarding common symptom and their motor function need to be related to the repeated and time-stamped assessment; with this, the full extent of patient’s condition could be revealed. The smartphone enables and facilitates the remote, long-term and repeated assessment of PD symptoms. Two types of collected data from smartphone were used, one during a three year, and another during one-day clinical study. The data were collected from series of tests consisting of tapping and spiral motor tests. During the second time scale data collection, along smartphone-based measurements patients were video recorded while performing standardized motor tasks according to Unified Parkinson’s disease rating scales (UPDRS).At first, the objective of this thesis was to elaborate the state of the art, sensor systems, and measures that were used to detect, assess and quantify the four cardinal and dyskinetic motor symptoms. This was done through a review study. The review showed that smartphones as the new generation of sensing devices are preferred since they are considered as part of patients’ daily accessories, they are available and they include high-resolution activity data. Smartphones can capture important measures such as forces, acceleration and radial displacements that are useful for assessing PD motor symptoms.Through the obtained insights from the review study, the second objective of this thesis was to investigate whether a combination of tapping and spiral drawing tests could be useful to quantify dexterity in PD. More specifically, the aim was to develop data-driven methods to quantify and characterize dexterity in PD. The results from this study showed that tapping and spiral drawing tests that were collected by smartphone can detect movements reasonably well related to under- and over-medication.The thesis continued by developing an Approximate Entropy (ApEn)-based method, which aimed to measure the amount of temporal irregularity during spiral drawing tests. One of the disabilities associated with PD is the impaired ability to accurately time movements. The increase in timing variability among patients when compared to healthy subjects, suggests that the Basal Ganglia (BG) has a role in interval timing. ApEn method was used to measure temporal irregularity score (TIS) which could significantly differentiate the healthy subjects and patients at different stages of the disease. This method was compared to two other methods which were used to measure the overall drawing impairment and shakiness. TIS had better reliability and responsiveness compared to the other methods. However, in contrast to other methods, the mean scores of the ApEn-based method improved significantly during a 3-year clinical study, indicating a possible impact of pathological BG oscillations in temporal control during spiral drawing tasks. In addition, due to the data collection scheme, the study was limited to have no gold standard for validating the TIS. However, the study continued to further investigate the findings using another screen resolution, new dataset, new patient groups, and for shorter term measurements. The new dataset included the clinical assessments of patients while they performed tests according to UPDRS. The results of this study confirmed the findings in the previous study. Further investigation when assessing the correlation of TIS to clinical ratings showed the amount of temporal irregularity present in the spiral drawing cannot be detected during clinical assessment since TIS is an upper limb high frequency-based measure.
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| 4. |
- Aghanavesi, Somayeh, 1981-, et al.
(författare)
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Verification of a Method for Measuring Parkinson's Disease Related Temporal Irregularity in Spiral Drawings
- 2017
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Ingår i: Sensors. - Basel : MDPI AG. - 1424-8220. ; 17:10
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Tidskriftsartikel (refereegranskat)abstract
- -value = 0.02). Test-retest reliability of TIS was good with Intra-class Correlation Coefficient of 0.81. When assessing changes in relation to treatment, TIS contained some information to capture changes from Off to On and wearing off effects. However, the correlations between TIS and clinical scores (UPDRS and Dyskinesia) were weak. TIS was able to differentiate spiral drawings drawn by patients in an advanced stage from those drawn by healthy subjects, and TIS had good test-retest reliability. TIS was somewhat responsive to single-dose levodopa treatment. Since TIS is an upper limb high-frequency-based measure, it cannot be detected during clinical assessment.
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| 5. |
- Ahmed, Mobyen Uddin, et al.
(författare)
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A fuzzy rule-based decision support system for Duodopa treatment in Parkinson
- 2006
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Ingår i: 23rd annual workshop of the Swedish Artificial Intelligence Society. - Umeå.
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Konferensbidrag (refereegranskat)abstract
- A decision support system (DSS) was implemented based on a fuzzy logic inference system (FIS) to provide assistance in dose alteration of Duodopa infusion in patients with advanced Parkinson’s disease, using data from motor state assessments and dosage. Three-tier architecture with an object oriented approach was used. The DSS has a web enabled graphical user interface that presents alerts indicating non optimal dosage and states, new recommendations, namely typical advice with typical dose and statistical measurements. One data set was used for design and tuning of the FIS and another data set was used for evaluating performance compared with actual given dose. Overall goodness-of-fit for the new patients (design data) was 0.65 and for the ongoing patients (evaluation data) 0.98. User evaluation is now ongoing. The system could work as an assistant to clinical staff for Duodopa treatment in advanced Parkinson’s disease.
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| 6. |
- Begum, Shahina, et al.
(författare)
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Induction of an Adaptive Neuro-Fuzzy Inference System for investing fluctuation in Parkinson’s disease
- 2006
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Ingår i: 23rd annual workshop of the Swedish Artificial Intelligence Society. - Umeå.
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Konferensbidrag (refereegranskat)abstract
- This paper presents a methodology to formulate natural language rules for an adaptive neuro-fuzzy system based on discovered knowledge, supported by prior knowledge and statistical modeling. Relationships between disease related variables and fluctuations in Parkinson’s disease is often complex. Experts have simplified but mostly reliable “fuzzy” rules based on experience. These rules could be improved using statistical methods and neural nets. This gives clinicians a valuable tool to explore the importance of different variables and their relations in a disease and could aid treatment selection. A prototype using the proposed methodology has been used to induce an Adaptive Neuro Fuzzy Inference Model that has been used to “discover” relationships between fluctuation, treatment and disease severity. More data is needed to confirm these findings. The project shows that artificial intelligence techniques and methods in combination with statistical methods offer medical research and applications valuable opportunities.
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| 7. |
- Brännström, Mattias, et al.
(författare)
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Classification of structural timber by decision trees : a comparison to the certified method
- 2009
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Ingår i: Forest Products Journal. - Madison WI : Forest Products Society. - 0015-7473. ; 59:3, s. 53-61
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Tidskriftsartikel (refereegranskat)abstract
- This work is an example of how to adapt a classification method, in this case a classification tree, to the present standardized method for the development of settings for strength grading machines. Data from commercially available industrial strength grading equipment were used on a large sample (approximately 1440 pieces) of Norway spruce (Picea abies (L. Karsten)) in various sawn dimensions. The equipment is a multisensor scanning device combining planar X-ray and resonance frequency measurement. Destructive testing was done according to European standard EN408. The goal was to make the classification, based on machine data, as close as possible to the optimum grading, which was done according to standard. Two different approaches for classification by cost-sensitive decision trees were applied to the data and compared to classification accredited according to EN14081. Classification accuracy increased from 64% correctly classified to 73%, and a reduction from 33% False Negative to 23% was achieved. False Positive increased from 3% to 4%. The outcome was an increase in value for the producer by 0.9%–2.1% at 2007 average price level. The improvement came mainly from an in-yield increase in C30 by 10%.
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| 8. |
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| 9. |
- Dougherty, Mark, et al.
(författare)
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The April Fool Turing Test
- 2006
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Ingår i: tripleC. - 1726-670X. ; 4:2
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Tidskriftsartikel (refereegranskat)abstract
- This paper explores certain issues concerning the Turing test; non-termination, asymmetry and the need for a control experiment. A standard diagonalisation argument to show the non-computability of AI is extended to yields a socalled “April fool Turing test”, which bears some relationship to Wizard of Oz experiments and involves placing several experimental participants in a symmetrical paradox – the “April Fool Turing Test”. The fundamental question which is asked is whether escaping from this paradox is a sign of intelligence. An important ethical consideration with such an experiment is that in order to place humans in such a paradox it is necessary to fool them. Results from an actual April Fool Turing Test experiment are reported. It is concluded that the results clearly illustrate some of the difficulties and paradoxes which surround the classical Turing Test.
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| 10. |
- Fleyeh, Hasan, et al.
(författare)
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Extracting Body Landmarks from Videos for Parkinson Gait Analysis
- 2019
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Ingår i: Proceedings - IEEE Symposium on Computer-Based Medical Systems. - 9781728122861 ; , s. 379-384
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Konferensbidrag (refereegranskat)abstract
- Patients with Parkinson disease (PD) exhibit a gait disorder called festinating gait which is caused by deficiency of dopamine in the basal ganglia. To analyze gait of patients with PD, different spatiotemporal parameters such as stride length, cadence, and walking speed should be calculated. This paper aims to present a method to extract useful information represented by the positions of certain landmarks on the human body that can be used for analysis of PD patients’ gait. This method is tested using 132 videos collected from 7 PD patients and 7 healthy controls. The positions of 4 body landmarks, namely body’s center of gravity (COG), the position of the head, and the position of the feet, was computed using a total of more than 41000 of video frames. Results of object’s movement plots show high level of accuracy in the calculation of the body landmarks.
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