| 1. |
- Adiels, Martin, 1976, et al.
(author)
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Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans.
- 2015
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In: Frontiers in Physiology. - : Frontiers Media SA. - 1664-042X. ; 6:NOV, s. 342-
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Research review (peer-reviewed)abstract
- To develop novel strategies for prevention and treatment of dyslipidemia, it is essential to understand the pathophysiology of dyslipoproteinemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion, and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labeled with stable isotopes and mathematical modeling, provides us with a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering our understanding of the pathogenesis of dyslipoproteinemia.
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| 2. |
- Alm, Jonas, 1984, et al.
(author)
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Foreign-currency interest-rate swaps in asset–liability management for insurers
- 2013
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In: European Actuarial Journal. - : Springer Science and Business Media LLC. - 2190-9733 .- 2190-9741. ; 3:1, s. 133-158
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Journal article (peer-reviewed)abstract
- We consider an insurer with purely domestic business whose liabilities towards its policy holders have long durations. The relative shortage of domestic government bonds with long maturities makes the insurer’s net asset value sensitive to fluctuations in the zero rates used for liability valuation. Therefore, in order to increase the duration of the insurer’s assets, it is common practice for insurers to take a position as the fixed-rate receiver in an interest-rate swap. We assume that this is not possible in the domestic currency but in a foreign currency supporting a larger market of interest-rate swaps. Monthly data over 16 years are used as the basis for investigating the risks to the future net asset value of the insurer from using foreign-currency interest-rate swaps as a proxy for domestic ones in asset–liability management. We find that although a suitable position in swaps may reduce the standard deviation of the future net asset value it may significantly increase the exposure to tail risk that has a substantial effect on the estimation of the solvency capital requirements.
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| 3. |
- Altay, Özlem, et al.
(author)
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Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19
- 2021
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In: Advanced Science. - : Wiley. - 2198-3844. ; 8:17
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Journal article (peer-reviewed)abstract
- COVID-19 is associated with mitochondrial dysfunction and metabolic abnormalities, including the deficiencies in nicotinamide adenine dinucleotide (NAD+) and glutathione metabolism. Here it is investigated if administration of a mixture of combined metabolic activators (CMAs) consisting of glutathione and NAD+ precursors can restore metabolic function and thus aid the recovery of COVID-19 patients. CMAs include l-serine, N-acetyl-l-cysteine, nicotinamide riboside, and l-carnitine tartrate, salt form of l-carnitine. Placebo-controlled, open-label phase 2 study and double-blinded phase 3 clinical trials are conducted to investigate the time of symptom-free recovery on ambulatory patients using CMAs. The results of both studies show that the time to complete recovery is significantly shorter in the CMA group (6.6 vs 9.3 d) in phase 2 and (5.7 vs 9.2 d) in phase 3 trials compared to placebo group. A comprehensive analysis of the plasma metabolome and proteome reveals major metabolic changes. Plasma levels of proteins and metabolites associated with inflammation and antioxidant metabolism are significantly improved in patients treated with CMAs as compared to placebo. The results show that treating patients infected with COVID-19 with CMAs lead to a more rapid symptom-free recovery, suggesting a role for such a therapeutic regime in the treatment of infections leading to respiratory problems.
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| 4. |
- Altay, Özlem, et al.
(author)
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Current Status of COVID-19 Therapies and Drug Repositioning Applications
- 2020
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In: Iscience. - : Elsevier BV. - 2589-0042. ; 23:7
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Journal article (peer-reviewed)abstract
- The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.
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| 5. |
- Altay, Özlem, et al.
(author)
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Systems biology perspective for studying the gut microbiota in human physiology and liver diseases
- 2019
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In: EBioMedicine. - : Elsevier BV. - 2352-3964. ; 49:November, s. 363-373
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Research review (peer-reviewed)abstract
- The advancement in high-throughput sequencing technologies and systems biology approaches have revolutionized our understanding of biological systems and opened a new path to investigate unacknowledged biological phenomena. In parallel, the field of human microbiome research has greatly evolved and the relative contribution of the gut microbiome to health and disease have been systematically explored. This review provides an overview of the network-based and translational systems biology-based studies focusing on the function and composition of gut microbiota. We also discussed the association between the gut microbiome and the overall human physiology, as well as hepatic diseases and other metabolic disorders.
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| 6. |
- Ames, Ellery, et al.
(author)
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Cosmic string and black hole limits of toroidal Vlasov bodies in general relativity
- 2019
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In: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 99:2
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Journal article (peer-reviewed)abstract
- We numerically investigate limits of a two-parameter family of stationary solutions to the Einstein-Vlasov system. The solutions are toroidal and have nonvanishing angular momentum. As the parameters are tuned to more relativistic solutions (measured e.g., by an increasing redshift) we provide evidence for a sequence of solutions which approaches the extreme Kerr black hole family. Solutions with angular momentum larger than the square of the mass are also investigated, and in the relativistic limit the near-field geometry of such solutions is observed to become locally rotationally symmetric about the matter density. The existence of a deficit angle in these regions is investigated.
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| 7. |
- Andersson, Lars, et al.
(author)
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A new tensorial conservation law for Maxwell fields on the Kerr background
- 2017
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In: Journal of Differential Geometry. - : International Press of Boston. - 0022-040X .- 1945-743X. ; 105:2, s. 163-176
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Journal article (peer-reviewed)abstract
- A new, conserved, symmetric tensor field for a source-free Maxwell test field on a four-dimensional spacetime with a conformal Killing-Yano tensor, satisfying a certain compatibility condition, is introduced. In particular, this construction works for the Kerr spacetime.
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| 8. |
- Andersson, Lars Erik, et al.
(author)
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Decay of solutions to the Maxwell equation on the Schwarzschild background
- 2016
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In: Classical and Quantum Gravity. - : IOP Publishing. - 0264-9381 .- 1361-6382. ; 33:8
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Journal article (peer-reviewed)abstract
- A new Morawetz or integrated local energy decay estimate for Maxwell test fields on the exterior of a Schwarzschild black hole spacetime is proved. The proof makes use of a new superenergy tensor H-ab defined in terms of the Maxwell field and its first derivatives. The superenergy tensor, although not conserved, yields a conserved higher order energy current H-ab (partial derivative(t))(b). The tensor Hab vanishes for the static Coulomb field, and the Morawetz estimate proved here therefore yields integrated decay for the Maxwell field to the Coulomb solution on the Schwarzschild exterior.
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| 9. |
- Andersson, Magnus, et al.
(author)
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A proposed time-resolved X-ray scattering approach to track local and global conformational changes in membrane transport proteins
- 2008
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In: Structure. - : Elsevier BV. - 0969-2126 .- 1878-4186. ; 16:1, s. 21-28
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Journal article (peer-reviewed)abstract
- Time-resolved X-ray scattering has emerged as a powerful technique for studying the rapid structural dynamics of small molecules in solution. Membrane-protein-catalyzed transport processes frequently couple large-scale conformational changes of the transporter with local structural changes perturbing the uptake and release of the transported substrate. Using light-driven halide ion transport catalyzed by halorhodopsin as a model system, we combine molecular dynamics simulations with X-ray scattering calculations to demonstrate how small-molecule time-resolved X-ray scattering can be extended to the study of membrane transport processes. In particular, by introducing strongly scattering atoms to label specific positions within the protein and substrate, the technique of time-resolved wide-angle X-ray scattering can reveal both local and global conformational changes. This approach simultaneously enables the direct visualization of global rearrangements and substrate movement, crucial concepts that underpin the alternating access paradigm for membrane transport proteins.
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| 10. |
- Andersson, Pontus, 1971, et al.
(author)
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Radiative lifetimes of metastable states of negative ions
- 2006
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In: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622 .- 2469-9926 .- 2469-9934. ; 73, s. 032705-
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Journal article (peer-reviewed)abstract
- We present a technique for measuring the radiative lifetimes of metastable states of negative ions that involves the use of a heavy-ion storage ring. The method has been applied to investigate the radiative decay of the np(3) P-2(1/2) levels of Te-(n=5) and Se-(n=4) and the 3p(3) D-2 state of Si- for which the J=3/2 and 5/2 levels were unresolved. All of these states are metastable and decay primarily by emission of E2 and M1 radiation. Multi Configuration Dirac-Hartree-Fock calculations of rates for the transitions in Te- and Se- yielded lifetimes of 0.45 s and 4.7 s, respectively. The measured values agree well with these predicted values. In the case of the D-2 state of Si-, however, our measurement was only able to set a lower limit on the lifetime. The upper limit of the lifetime that can be measured with our apparatus is set by how long the ions can be stored in the ring, a limit determined by the rate of collisional detachment. Our lower limit of 1 min for the lifetime of the D-2 state is consistent with both the calculated lifetimes of 162 s for the D-2(3/2) level and 27.3 h for the D-2(5/2) level reported by O'Malley and Beck and 14.5 h and 12.5 h, respectively, from our Breit-Pauli calculations.
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