| 1. |
|
|
| 2. |
- Aasa, Anna, et al.
(författare)
-
Collecting dialect data and making use of them an interim report from Swedia 2000
- 2000
-
Ingår i: Proceedings FONETIK 2000. - University of Gothenburg. ; s. 17-20
-
Konferensbidrag (övrigt vetenskapligt)abstract
- This paper consists of two, somewhat disparate parts. In the first part, some experiences of two years of fieldwork are summarized, concentrating, as the subtitle suggests, on the very heart of phonetic fieldwork: the encounters and interviews with the informants. As a result of the fieldwork, the project now has access to recordings from approximately 1300 speakers of more than 100 dialects of Swedish. We are currently initiating research on various aspects of the sound patterns of these dialects. The second part of the paper is meant to give an overview of some of our research plans for the near future.
|
|
| 3. |
- Abendstein, Helmut, et al.
(författare)
-
Quality of life and head and neck cancer: A 5 year prospective study
- 2005
-
Ingår i: Laryngoscope. - 0023-852X. ; 115:12, s. 2183-2192
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Assessment of health-related quality of life (HRQL) in head and neck cancer patients from diagnosis to 5 years after start of treatment. STUDY DESIGN: A prospective, descriptive study METHODS: three hundred fifty-seven patients from Norway and Sweden filled in HRQL questionnaires, the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and the EORTC QLQ-H and N35, six times during the first year and then after 5 years. At 5 years, 167 (87%) of the 192 living patients filled in questionnaires. RESULTS: Group data: clinical significant improvements in HRQL were not found between 1 and 5 years. Problems with teeth, opening of the mouth, dryness in the mouth, and sticky saliva were persistent or worsening. Similar findings were found regardless of sex, age, stage, or site when clinical significant changes are considered. Patients who died between 1 and 5 years reported reduced HRQL on 15 of 28 scales at 1 year compared with the survivors. Individual data: 40% of patients reported improved global HRQL from diagnosis to 5 years after start of treatment. In addition, 11% had "top scores" at both assessment points. The pattern in global HRQL scores also applies for most of the other function and symptom scales. CONCLUSION: After the first year after treatment, recovery of the persisting side effects of treatment cannot be expected for the group as a whole. Patients must be prepared for this. Some individual patients experience improvement in global HRQL. HRQL assessments in daily clinical practice can identify patients who are in need of additional support and symptom relief.
|
|
| 4. |
- Abraham-Nordling, Mirna, et al.
(författare)
-
Incidence of Hyperthyroidism in Sweden.
- 2011
-
Ingår i: European journal of endocrinology. - 1479-683X. ; 165, s. 899-905
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction The incidence of hyperthyroidism has been reported in various countries to be 23-93/100 000 inhabitants per year. This extended study has evaluated the incidence for ∼40% of the Swedish population of 9 million inhabitants. Sweden is considered to be iodine sufficient country. Methods All patients including children, who were newly diagnosed with overt hyperthyroidism in the years 2003-2005, were prospectively registered in a multicenter study. The inclusion criteria are as follows: clinical symptoms and/or signs of hyperthyroidism with plasma TSH concentration below 0.2 mIE/l and increased plasma levels of free/total triiodothyronine and/or free/total thyroxine. Patients with relapse of hyperthyroidism or thyroiditis were not included. The diagnosis of Graves' disease (GD), toxic multinodular goiter (TMNG) and solitary toxic adenoma (STA), smoking, initial treatment, occurrence of thyroid-associated eye symptoms/signs, and demographic data were registered. Results A total of 2916 patients were diagnosed with de novo hyperthyroidism showing the total incidence of 27.6/100 000 inhabitants per year. The incidence of GD was 21.0/100 000 and toxic nodular goiter (TNG=STA+TMNG) occurred in 692 patients, corresponding to an annual incidence of 6.5/100 000. The incidence was higher in women compared with men (4.2:1). Seventy-five percent of the patients were diagnosed with GD, in whom thyroid-associated eye symptoms/signs occurred during diagnosis in every fifth patient. Geographical differences were observed. Conclusion The incidence of hyperthyroidism in Sweden is in a lower range compared with international reports. Seventy-five percent of patients with hyperthyroidism had GD and 20% of them had thyroid-associated eye symptoms/signs during diagnosis. The observed geographical differences require further studies.
|
|
| 5. |
- Abraham-Nordling, Mirna, et al.
(författare)
-
Thyroid-associated ophthalmopathy; quality of life follow-up of patients randomized to treatment with antithyroid drugs or radioiodine.
- 2010
-
Ingår i: European journal of endocrinology / European Federation of Endocrine Societies. - 1479-683X. ; 163:4, s. 651-7
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: The objective of this study was to investigate quality of life (QoL) in patients with Graves' disease treated with radioiodine or antithyroid drugs. Design and methods: The design of the study consists of an open, prospective, randomized multicenter trial between radioiodine and medical treatment. A total of 308 patients were included in the study group: 145 patients in the medical group and 163 patients in the radioiodine group. QoL was measured with a 36-item Short Form Health Status Survey questionnaire (SF-36) at six time points during the 48-month study period. Results: Patient who developed or got worse of thyroid-associated ophthalmopathy (TAO) at any time point during the 4-year study period (TAO group) had lower QoL when no respect was paid to the mode of treatment. TAO occurred in 75 patients who had radioiodine treatment at some time point during the study period as compared with TAO in 40 medically treated patients (P<0.0009). Comparisons between the group of patients who have had TAO versus the group without TAO, in relation to treatments and time, showed significantly decreased QoL scores for the TAO groups at several time points during the study. In patients without TAO, there were no differences in QoL related to mode of treatment. Conclusions: The QoL in patients with Graves' ophthalmopathy was similar in radioiodine and medically treated patients, but patients who developed or had worsening of TAO had decreased QoL independent of mode of treatment. Furthermore, patients with TAO recovered physically within 1 year but it took twice as long for them to recover mentally.
|
|
| 6. |
- Abrahamsson, Jonas, 1954-, et al.
(författare)
-
Improved outcome after relapse in children with acute myeloid leukaemia
- 2007
-
Ingår i: Br J Haematol. - 0007-1048. ; 136:2, s. 229-236
-
Tidskriftsartikel (refereegranskat)abstract
- In the Nordic Society for Paediatric Haematology and Oncology paediatric study acute myeloid leukaemia (AML) 93, event-free survival was 50% and overall survival was 66%, indicating that many patients were cured following relapse. Factors influencing outcome in children with relapsed AML were investigated. The study included all 146 children in the Nordic countries diagnosed with AML between 1988 and 2003, who relapsed. Data on disease characteristics and relapse treatment were related to outcome. Sixty-six percentage achieved remission with survival after relapse (5 years) 34 +/- 4%. Of 122 patients who received re-induction therapy, 77% entered remission with 40 +/- 5% survival. Remission rates were similar for different re-induction regimens but fludarabine, cytarabine, granulocyte colony-stimulating factor-based therapy had low treatment-related mortality. Prognostic factors for survival were duration of first complete remission (CR1) and stem cell transplantation (SCT) in CR1. In early relapse (< 1 year in CR1), survival was 21 +/- 5% compared with 48 +/- 6% in late relapse. For children receiving re-induction therapy, survival in early relapse was 29 +/- 6% and 51 +/- 6% in late. Patients treated in CR1 with SCT, autologous SCT or chemotherapy had a survival of 18 +/- 9, 5 +/- 5 and 41 +/- 5%, respectively. Survival was 62 +/- 6% in 64 children given SCT as part of their relapse therapy. A significant proportion of children with relapsed AML can be cured, even those with early relapse. Children who receive re-induction therapy, enter remission and proceed to SCT can achieve a cure rate of 60%.
|
|
| 7. |
- Abrahamsson, Jonas, 1954-, et al.
(författare)
-
Response-guided induction therapy in pediatric acute myeloid leukemia with excellent remission rate.
- 2011
-
Ingår i: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 1527-7755. ; 29:3, s. 310-5
-
Tidskriftsartikel (refereegranskat)abstract
- The NOPHO-AML 2004 induction strategy gives an excellent remission rate with low toxic mortality in an unselected population. Outcome is worse in patients with intermediate response but may be improved by intensifying consolidation in this group using SCT.
|
|
| 8. |
- Abramo, Antonio, et al.
(författare)
-
Osteotomy of distal radius fracture malunion using a fast remodeling bone substitute consisting of calcium sulphate and calcium phosphate.
- 2010
-
Ingår i: Journal of biomedical materials research. Part B, Applied biomaterials. - 1552-4981. ; 92:1, s. 281-6
-
Tidskriftsartikel (refereegranskat)abstract
- Malunion after a distal radius fracture can be treated with an osteotomy of the distal radius. Autologous iliac crest bone graft is often used to fill the gap, but the procedure is associated with donor site morbidity. In this study a novel fast resorbing biphasic bone substitute consisting of a mixture of calcium sulphate and calcium phosphate is used (Cerament BoneSupport AB, Sweden). Fifteen consecutive patients, with a mean age of 52 (27-71) years were included. All had a malunion after a distal radius fracture and underwent an osteotomy. A fragment specific fixation system, TriMed(R) (TriMed, Valencia, CA), consisting of a Buttress Pin(R) and a Radial Pin Plate(R) were used for fixation and a calcium sulphate and calcium phosphate mixture as bone substitute. The patients were followed for 1 year. Grip strength increased from 61 (28-93)% of the contralateral hand to 85 (58-109)%, p < 0.001. DASH scores decreased from 37 (22-61) to 24 (2-49) p = 0.003. Radiographically all osteotomies healed. An increase of ulnar variance was noted during healing from 1.8 mm immediately postoperatively to 2.6 mm at final follow up. Osteotomy can increase grip strength and decease disability after a malunited fracture. In the present series the bone substitute was replaced by bone, but a minor loss of the achieved radiographic correction was noted in some patients during osteotomy healing. A more rigid fixation may improve the radiographic outcome with this kind of bone substitute. (c) 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010.
|
|
| 9. |
- Abramsson, Alexandra, et al.
(författare)
-
No association of LOXL1 gene polymorphisms with Alzheimer's disease.
- 2011
-
Ingår i: Neuromolecular medicine. - 1559-1174. ; 13:2, s. 160-6
-
Tidskriftsartikel (refereegranskat)abstract
- Aggregation of amyloid-beta is one of the major characteristics in brains of patients with Alzheimer's disease (AD). Although several mechanisms behind the formation of such aggregates have been suggested the regulatory factors are still unknown. The present study aimed at investigating the association of lysyl oxidase-like 1 (LOXL1) polymorphisms with AD diagnosis and cerebrospinal fluid biomarkers (CSF) for the disease. Proteins of the lysyl oxidase (LOX) family are involved in cross-linking extracellular matrix proteins to insoluble fibers and have been associated with neurodegenerative diseases including AD. Genetic polymorphisms in LOXL1 (rs1048661, rs3825942, and rs2165241) have been linked to exfoliation syndrome and exfoliation glaucoma, conditions that have shown association with AD. The polymorphisms were genotyped by Taqman allelic discrimination in a study sample including AD patients (n = 318) and controls (n = 575). In a subgroup of the population, the polymorphisms were analyzed in relation to APOE epsilon 4 genotype and to CSF (T-tau, P-tau, and A beta(1-42)). No evidence for associations of these polymorphisms with risk for AD or any of the studied CSF biomarkers measured was found. These results do not support LOXL1 as being a major risk gene for AD.
|
|
| 10. |
- Achberger, Christine, 1968-, et al.
(författare)
-
Performance of the Rossby Centre regional atmospheric model in Southern Sweden: comparison of simulated and observed precipitation
- 2003
-
Ingår i: Theoretical and Applied Climatology. - Springer Wien. - 0177-798X. ; 76:3-4, s. 219-234
-
Tidskriftsartikel (refereegranskat)abstract
- Two climate model simulations made with the Rossby Centre regional Atmospheric model version I (RCA1) are evaluated for the precipitation climate in Scania, southern-most Sweden. These simulations are driven by the HadCM2 and the ECHAM4/OPYC3 global circulation models (GCMs) for 10 years. Output from the global and the regional simulations are compared with an observational data set, constructed from a dense precipitation gauge network in Scania. Area-averaged time series corresponding to the size and location of the RCA1 grid points in Scania have been created (the Scanian Data Set). This data set was compared to a commonly used gridded surface climatology provided by the Climatic Research Unit (CRU). Relatively large differences were found, mainly due to the fact that the CRU-climatology uses fewer stations and lacks a correction for rain-gauge under-catch. This underlines the importance of the data set chosen for model evaluations. The validation is carried out at a large scale including the whole area of Scania and at the finest resolution of RCA1 (the grid point level). When integrated over the whole area of Scania, RCA1 improves the shape of the annual precipitation cycle and the inter-annual variability compared to output from the GCMs. The RCA1 control climate is generally too wet compared to the observations. At the grid point level, RCA1 improves the simulation of the variability compared to the GCMs. There is a strong positive correlation between precipitation and altitude in all seasons in the observations. This relationship is, however, much weaker and even reversed in the RCA1 simulations. Analysis of the dense rain gauge network reveals features of spatial variability at around 20-35 km in the area and indicates that a finer resolution is needed if the spatial variability in the area is to be better captured by RCA1.
|
|
