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Continuing high ear...
Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the Swedish Adult Acute Leukemia Registry.
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- Lehmann, S (author)
- Karolinska Institutet,Karolinska University Hospital
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- Ravn, A (author)
- Karolinska Institutet,Karolinska University Hospital
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- Carlsson, L (author)
- Karolinska University Hospital
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- Antunovic, Petar (author)
- Linköpings universitet,Hälsouniversitetet,Kirurgi
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- Deneberg, S (author)
- Karolinska Institutet,Karolinska University Hospital,Sahlgrens University Hospital
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- Möllgård, L (author)
- Karolinska Institutet,Karolinska University Hospital
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- Derolf, A Rangert (author)
- Karolinska University Hospital
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- Stockelberg, Dick, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Tidefelt, Ulf, 1951- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Orebro University Hospital
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- Wahlin, Anders (author)
- Umeå universitet,Institutionen för strålningsvetenskaper,Umea University
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- Wennström, Lovisa (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,Sahlgrens University Hospital
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- Höglund, M (author)
- Uppsala universitet,Medicin,Hematologi,Acad Hospital, Uppsala
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- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skane University Hospital
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Ravn, S (author)
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Högberg, M (author)
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(creator_code:org_t)
- 2011-04-19
- 2011
- English.
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In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 25:7, s. 1128-34
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Abstract
Subject headings
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- Our knowledge about acute promyelocytic leukemia (APL) patients is mainly based on data from clinical trials, whereas population-based information is scarce. We studied APL patients diagnosed between 1997 and 2006 in the population-based Swedish Adult Acute Leukemia Registry. Of a total of 3897 acute leukemia cases, 3205 (82%) had non-APL acute myeloid leukemia (AML) and 105 (2.7%) had APL. The incidence of APL was 0.145 per 100,000 inhabitants per year. The median age at the time of diagnosis was 54 years; 62% were female and 38% male. Among younger APL patients, female sex predominated (89% of patients <40 years). Of the 105 APL patients, 30 (29%) died within 30 days (that is, early death (ED)) (median 4 days) and 28 (26%) within 14 days from diagnosis. In all, 41% of the EDs were due to hemorrhage; 35% of ED patients never received all-trans-retinoic acid treatment. ED rates increased with age but more clearly with poor performance status. ED was also associated with high white blood cells, lactate dehydrogenase, creatinine, C-reactive protein and low platelet count. Of non-ED patients, 97% achieved complete remission of which 16% subsequently relapsed. In total, 62% are still alive at 6.4 years median follow-up. We conclude that ED rates remain very high in an unselected APL population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Adolescent
- Adult
- Age Distribution
- Aged
- Aged
- 80 and over
- Antineoplastic Combined Chemotherapy Protocols
- therapeutic use
- Cause of Death
- Female
- Hemorrhage
- etiology
- mortality
- Humans
- Incidence
- Kaplan-Meier Estimate
- Leukemia
- Promyelocytic
- Acute
- blood
- complications
- diagnosis
- drug therapy
- mortality
- Male
- Middle Aged
- Mortality
- trends
- Prognosis
- Registries
- Risk Factors
- Sex Distribution
- Sweden
- epidemiology
- Time Factors
- Young Adult
- acute promyelocytic leukemia; incidence; early mortality; hemorrhagic death; population based
- acute promyelocytic leukemia
- incidence
- early mortality
- hemorrhagic
- death
- population based
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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Leukemia
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To the university's database
- By the author/editor
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Lehmann, S
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Ravn, A
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Carlsson, L
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Antunovic, Petar
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Deneberg, S
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Möllgård, L
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show more...
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Derolf, A Ranger ...
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Stockelberg, Dic ...
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Tidefelt, Ulf, 1 ...
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Wahlin, Anders
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Wennström, Lovis ...
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Höglund, M
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Juliusson, Gunna ...
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Ravn, S
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Högberg, M
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Leukemia
- By the university
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University of Gothenburg
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Örebro University
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Umeå University
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Lund University
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Uppsala University
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Karolinska Institutet
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Linköping University
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