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Sökning: LAR1:gu > Tidskriftsartikel > Refereegranskat > Sjöström Lars > Olbers Torsten 1964

  • Resultat 1-7 av 7
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1.
  • Gabrielsson, Britt G., 1957-, et al. (författare)
  • Depot-specific expression of fibroblast growth factors in human adipose tissue.
  • 2002
  • Ingår i: Obesity research. - 1071-7323. ; 10:7, s. 608-16
  • Tidskriftsartikel (refereegranskat)abstract
    • We have investigated the expression of several fibroblast growth factors (FGFs) and FGF-receptors (FGFRs) in human adipose tissue and adipose-tissue cell fractions obtained from both subcutaneous (sc) and omental (om) depots.
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2.
  • Gabrielsson, Britt G., 1957-, et al. (författare)
  • High expression of complement components in omental adipose tissue in obese men.
  • 2003
  • Ingår i: Obesity research. - 1071-7323. ; 11:6, s. 699-708
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: Accumulation of visceral fat is recognized as a predictor of obesity-related metabolic disturbances. Factors that are predominantly expressed in this depot could mediate the link between visceral obesity and associated diseases. RESEARCH METHODS AND PROCEDURES: Paired subcutaneous and omental adipose tissue biopsies were obtained from 10 obese men. Gene expression was analyzed by DNA microarrays in triplicate and by real-time polymerase chain reaction. Serum C3 and C4 were analyzed by radial immunodiffusion assays in 91 subjects representing a cross section of the general population. Body composition was measured by computerized tomography. RESULTS: Complement components C2, C3, C4, C7, and Factor B had higher expression in omental compared with subcutaneous adipose tissue ( approximately 2-, 4-, 17-, 10-, and 7-fold, respectively). In addition, adipsin, which belongs to the alternative pathway, and the classical pathway components C1QB, C1R, and C1S were expressed in both depots. Analysis of tissue distribution showed high expression of C2, C3, and C4 in omental adipose tissue, and only liver had higher expression of these genes. Serum C3 levels correlated with both visceral and subcutaneous adipose tissue in both men (r = 0.65 and p < 0.001 and r = 0.52 and p < 0.001, respectively) and women (r = 0.34 and p = 0.023 and r = 0.49 and p < 0.001, respectively), whereas C4 levels correlated with only visceral fat in men (r = 0.36, p = 0.015) and with both depots in women (visceral: r = 0.58, p < 0.001; and subcutaneous: r = 0.51, p < 0.001). DISCUSSION: Recent studies show that the metabolic syndrome is associated with chronically elevated levels of several immune markers, some of which may have metabolic effects. The high expression of complement genes in intra-abdominal adipose tissue might suggest that the complement system is involved in the development of visceral adiposity and/or contributes to the metabolic complications associated with increased visceral fat mass.
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4.
  • Olbers, Torsten, 1964-, et al. (författare)
  • Body composition, dietary intake, and energy expenditure after laparoscopic Roux-en-Y gastric bypass and laparoscopic vertical banded gastroplasty: a randomized clinical trial.
  • 2006
  • Ingår i: Annals of surgery. - 0003-4932. ; 244:5, s. 715-22
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To assess body composition, eating pattern, and basal metabolic rate in patients undergoing obesity surgery in a randomized trial. INTRODUCTION: There is limited knowledge regarding how different bariatric surgical techniques function in terms of altering body composition, dietary intake, and basic metabolic rate. METHODS: Non-superobese patients were randomized to laparoscopic Roux-en-Y gastric bypass (LGBP, n = 37) or laparoscopic vertical banded gastroplasty (LVBG, n = 46). Anthropometry, dual-energy x-ray absorptiometry (DEXA), computed tomography (CT), indirect calorimetry, and reported dietary intake were registered prior to and 1 year after surgery. RESULTS: Follow-up rate was 97.6%. LGBP patients had significantly greater reduction of waist circumference and sagittal diameter compared with LVBG. DEXA demonstrated a larger reduction of body fat in all compartments after LGBP, especially at the trunk (P<0.001). CT demonstrated more reduction of the visceral fat (P=0.016). Patients were able to eat all types of food after LGBP, although about 30% claimed they avoided fats. LGBP patients decreased their proportion of dietary fat significantly more than those operated on with LVBG (P = 0.005), who consumed more sweet foods and avoided whole meat and vegetables. Lean tissue mass (LTM) was proportionally less reduced, especially in men, after LGBP. The decreases in BMR postoperatively reflected the lower body mass in a pattern that did not differ among the groups. CONCLUSION: LGBP patients demonstrated better outcomes compared with LVBG patients in terms of body composition. Energy expenditure developed as expected postoperatively. A "steering" away from fatty foods after LGBP may be an important mechanism of action in gastric bypass.
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5.
  • Sjöström, Lars, et al. (författare)
  • Bariatric surgery and long-term cardiovascular events.
  • 2012
  • Ingår i: JAMA : the journal of the American Medical Association. - 1538-3598. ; 307:1, s. 56-65
  • Tidskriftsartikel (refereegranskat)abstract
    • Obesity is a risk factor for cardiovascular events. Weight loss might protect against cardiovascular events, but solid evidence is lacking.
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6.
  • Sjöström, Lars, et al. (författare)
  • Effects of bariatric surgery on mortality in Swedish obese subjects.
  • 2007
  • Ingår i: The New England journal of medicine. - 1533-4406. ; 357:8, s. 741-52
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Obesity is associated with increased mortality. Weight loss improves cardiovascular risk factors, but no prospective interventional studies have reported whether weight loss decreases overall mortality. In fact, many observational studies suggest that weight reduction is associated with increased mortality. METHODS: The prospective, controlled Swedish Obese Subjects study involved 4047 obese subjects. Of these subjects, 2010 underwent bariatric surgery (surgery group) and 2037 received conventional treatment (matched control group). We report on overall mortality during an average of 10.9 years of follow-up. At the time of the analysis (November 1, 2005), vital status was known for all but three subjects (follow-up rate, 99.9%). RESULTS: The average weight change in control subjects was less than +/-2% during the period of up to 15 years during which weights were recorded. Maximum weight losses in the surgical subgroups were observed after 1 to 2 years: gastric bypass, 32%; vertical-banded gastroplasty, 25%; and banding, 20%. After 10 years, the weight losses from baseline were stabilized at 25%, 16%, and 14%, respectively. There were 129 deaths in the control group and 101 deaths in the surgery group. The unadjusted overall hazard ratio was 0.76 in the surgery group (P=0.04), as compared with the control group, and the hazard ratio adjusted for sex, age, and risk factors was 0.71 (P=0.01). The most common causes of death were myocardial infarction (control group, 25 subjects; surgery group, 13 subjects) and cancer (control group, 47; surgery group, 29). CONCLUSIONS: Bariatric surgery for severe obesity is associated with long-term weight loss and decreased overall mortality.
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7.
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Lönroth, Hans, 1952- ... (6)
Carlsson, Lena M S, ... (5)
Carlsson, Björn, 195 ... (4)
Lindroos, Anna-Karin ... (3)
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Jacobson, Peter, 196 ... (3)
Näslund, Ingmar, (3)
Lönn, Lars, 1956-, (3)
Peltonen, Markku, 19 ... (3)
Bengtsson, Calle, 19 ... (2)
Lönn, Malin, 1959-, (2)
Gabrielsson, Britt G ... (2)
Jernås, Margareta, 1 ... (2)
Wedel, Hans, (2)
Karason, Kristjan, 1 ... (2)
Wallenius, Ville, 19 ... (2)
Fändriks, Lars, 1956 ... (2)
Bouchard, Claude (2)
Karlsson, Jan, 1950- ... (2)
Stenlöf, Kaj, 1965-, (2)
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Göteborgs universitet (7)
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