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1.
  • Agebjöm, Anders (creator_code:aut_t)
  • Development of the form and meaning of defmiteness in Russian-speaking learners of Swedish
  • 2021
  • record:In_t: Norsk Lingvistisk Tidsskrift. - 0800-3076 .- 2387-6719. ; 39:1, s. 41-68
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • The study investigates the development of defmiteness in two groups of Russian-speaking learners of Swedish, one beginner group and one more advanced group. While Russian does not have articles, Swedish expresses defmiteness through a complex noun-phrase (NP) structure. Using an oral elicitation task, the study examines the learners' ability to produce morphemes that encode (in)defmiteness, their ability to accurately choose between indefinite and definite forms, and the relationship between these two abilities. Findings include that the complex NP structure emerged gradually while there was no evident development with regard to meaning. Initially, however, learners who used the morphemes more also tended to overuse them, while later in development those who produced many morphemes were also more likely to use them accurately. The paper thus demonstrates that the acquisition of a morphosyntactic form and the association of this form with its meaning are two separate processes to some extent.
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2.
  • Aronsson, Gunnar, et al. (creator_code:aut_t)
  • A systematic review including meta-analysis of work environment and burnout symptoms
  • 2017
  • record:In_t: Bmc Public Health. - : Springer Science and Business Media LLC. - 1471-2458. ; 17:264
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • Background: Practitioners and decision makers in the medical and insurance systems need knowledge on the relationship between work exposures and burnout. Many burnout studies -original as well as reviews-restricted their analyses to emotional exhaustion or did not report results on cynicism, personal accomplishment or global burnout. To meet this need we carried out this review and meta-analyses with the aim to provide systematically graded evidence for associations between working conditions and near-future development of burnout symptoms. Methods: A wide range of work exposure factors was screened. Inclusion criteria were: 1) Study performed in Europe, North America, Australia and New Zealand 1990-2013. 2) Prospective or comparable case control design. 3) Assessments of exposure (work) and outcome at baseline and at least once again during follow up 1-5 years later. Twenty-five articles met the predefined relevance and quality criteria. The GRADE-system with its 4-grade evidence scale was used. Results: Most of the 25 studies focused emotional exhaustion, fewer cynicism and still fewer personal accomplishment. Moderately strong evidence (grade 3) was concluded for the association between job control and reduced emotional exhaustion and between low workplace support and increased emotional exhaustion. Limited evidence (grade 2) was found for the associations between workplace justice, demands, high work load, low reward, low supervisor support, low co-worker support, job insecurity and change in emotional exhaustion. Cynicism was associated with most of these work factors. Reduced personal accomplishment was only associated with low reward. There were few prospective studies with sufficient quality on adverse chemical, biological and physical factors and burnout. Conclusion: While high levels of job support and workplace justice were protective for emotional exhaustion, high demands, low job control, high work load, low reward and job insecurity increased the risk for developing exhaustion. Our approach with a wide range of work exposure factors analysed in relation to the separate dimensions of burnout expanded the knowledge of associations, evidence as well as research needs. The potential of organizational interventions is illustrated by the findings that burnout symptoms are strongly influenced by structural factors such as job demands, support and the possibility to exert control.
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3.
  • Arvidsson, Matilda, et al. (creator_code:aut_t)
  • The turn to history in international law and the sources doctrine : Critical approaches and methodological imaginaries
  • 2019
  • record:In_t: Leiden Journal of International Law. - 0922-1565. ; 33:1, s. 37-56
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • Expanding now familiar debates about the impact of the 'historical turn' upon the field of international law, this article considers some of the different ways in which 'turn to history' scholars have confronted the methodological and theoretical tensions arising from the central, yet paradoxical, role occupied by the sources doctrine in international law. We suggest that the anxiety over the sources of international law as the basic methodological precepts of the discipline has been a catalyzing element for a radical reengagement with the canon of international law, one with a significant impact on the field's existing parameters and doctrinal limits. Within the three streams of scholarship we explore here, history has become a site of creative engagement for scholars in opening up the discipline to diverse ends, one in which a new doctrinal universe can be created, and new issues, sources, subjects, and approaches can be explored. Yet, by opening up international law's sources doctrine, reactionary causes and unjust ends may equally well be the result. This account is an attempt at diversifying the narrative surrounding the causal relationship between history and the ongoing changes to the field of international law, along with the differential practices, techniques and epistemological foundations behind the history of international law as an evolving discipline, and of the different scholarly motivations of its specialists.
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4.
  • Ashton, Nicholas J., et al. (creator_code:aut_t)
  • Update on biomarkers for amyloid pathology in Alzheimer's disease
  • 2018
  • record:In_t: Biomarkers in Medicine. - : Future Medicine Ltd. - 1752-0363 .- 1752-0371. ; 12:7, s. 799-812
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • At the center of Alzheimer's disease pathogenesis is the aberrant aggregation of amyloid-β (Aβ) into oligomers, fibrils and plaques. Effective monitoring of Aβ deposition directly in patients is essential to assist anti-Aβ therapeutics in target engagement and participant selection. In the advent of approved anti-Aβ therapeutics, biomarkers will become of fundamental importance in initiating treatments having disease modifying effects at the earliest stage. Two well-established Aβ biomarkers are widely utilized: Aβ-binding ligands for positron emission tomography and immunoassays to measure Aβ42 in cerebrospinal fluid. In this review, we will discuss the current clinical, diagnostic and research state of biomarkers for Aβ pathology. Furthermore, we will explore the current application of blood-based markers to assess Aβ pathology.
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5.
  • Askmyr, Maria K, et al. (creator_code:aut_t)
  • Towards a better understanding and new therapeutics of osteopetrosis.
  • 2008
  • record:In_t: British journal of haematology. - : Wiley. - 1365-2141 .- 0007-1048. ; 140:6, s. 597-609
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • Lack of or dysfunction in osteoclasts result in osteopetrosis, a group of rare but often severe, genetic disorders affecting skeletal tissue. Increase in bone mass results in skeletal malformation and bone marrow failure that may be fatal. Many of the underlying defects have lately been characterized in humans and in animal models of the disease. In humans, these defects often involve mutations in genes expressing proteins involved in the acidification of the osteoclast resorption compartment, a process necessary for proper bone degradation. So far, the only cure for children with severe osteopetrosis is allogeneic hematopoietic stem cell (HSC) transplantation but without a matching donor this form of therapy is far from optimal. The characterization of the genetic defects opens up the possibility for gene replacement therapy as an alternative. Accordingly, HSC-targeted gene therapy in a mouse model of infantile malignant osteopetrosis was recently shown to correct many aspects of the disease.
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6.
  • Askmyr, Maria, et al. (creator_code:aut_t)
  • Prospects for gene therapy of osteopetrosis.
  • 2009
  • record:In_t: Current gene therapy. - 1566-5232. ; 9:3, s. 150-9
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • Dysfunction in or lack of osteoclasts result in osteopetrosis, a group of rare but often severe, genetic disorders characterized by an increase in bone mass, skeletal malformations and bone marrow failure that may be fatal. Several of the underlying defects have lately been characterized in humans and in animal disease models. In humans, these defects often involve mutations in genes expressing proteins involved in the acidification of the osteoclast sub-cellular compartment, a process necessary for proper bone resorption. So far, the only cure for children with severe osteopetrosis is allogeneic hematopoietic stem cell transplantation (SCT). However, the characterization of the genetic defects opens up the possibility for gene replacement therapy as an alternative to SCT. Recently, gene therapy targeting hematopoietic stem cells (HSC) in a mouse model of infantile malignant osteopetrosis was shown to correct many aspects of the disease. Here we review important aspects of this group of diseases and discuss the prospects for development of gene therapy of osteopetrosis.
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7.
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8.
  • Banzhaf, Stefan, 1980, et al. (creator_code:aut_t)
  • A review of contamination of surface-, ground-, and drinking water in Sweden by perfluoroalkyl and polyfluoroalkyl substances (PFASs)
  • 2017
  • record:In_t: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 46:3, s. 335-346
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are found in aquatic systems, flora, and fauna worldwide. These potentially harmful compounds are also frequently detected in Sweden and have already resulted in severe problems for public drinking water supply, i.e., some wells had to be closed due to high PFAS concentrations both in raw water and produced drinking water. Knowledge on PFAS occurrence in Sweden is still quite low, although monitoring is currently ongoing. This work describes potential sources for PFASs to enter the drinking water supply in Sweden and compares different occurrences of PFASs in raw and drinking water in the country. Moreover, the monitoring history, the legal situation, and remediation actions taken are presented. Finally, future challenges and the way forward in Sweden are discussed.
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9.
  • Bertilsson, Monica, et al. (creator_code:aut_t)
  • Preventiva insatser för att förebygga och minska sjukskrivning på grund av psykisk ohälsa – en litteraturöversikt av svensk forskning och förändringar i svensk lagstiftning.
  • 2017
  • record:In_t: Socialmedicinsk Tidskrift. - 0037-833X. ; 94:5, s. 531-545
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • Psykisk ohälsa utgör idag det främsta skälet till sjukskrivning i Sverige och involverar i hög grad arbetsplatser. I denna litteraturöversikt har vi mellan 2000−2016 undersökt dels svenska primär- och sekundärpreventiva insatser som inkluderar arbetsplatsen för att förhindra eller minska sjukskrivning på grund av vanlig psykisk sjukdom dels kartlagt hur svensk lagstiftning och policy inom rehabiliteringsområdet förändrats, tillkommit och kontextuellt påverkat primär- och sekundärinsinsatser. Vi fann inga svenska studier om primärprevention på arbetsplatsen och endast sex sekundärpreventiva insatser som inkluderat arbetsplatsen, varav två lett till kortare sjukskrivning. Vad gäller förändring av lagar och policy har dessa snarare stimulerat sekundär och tertiär prevention än primärprevention. Översikten visar att det finns ett stort behov av att utveckla nationella preventionsstudier som inkluderar arbetsplatsen.
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10.
  • Brand, Abby L., et al. (creator_code:aut_t)
  • The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer's disease : a literature review
  • 2022
  • record:In_t: Alzheimer's Research & Therapy. - : Springer Science and Business Media LLC. - 1758-9193. ; 14:1, s. 195-195
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • The extracellular buildup of amyloid beta (Aβ) plaques in the brain is a hallmark of Alzheimer's disease (AD). Detection of Aβ pathology is essential for AD diagnosis and for identifying and recruiting research participants for clinical trials evaluating disease-modifying therapies. Currently, AD diagnoses are usually made by clinical assessments, although detection of AD pathology with positron emission tomography (PET) scans or cerebrospinal fluid (CSF) analysis can be used by specialty clinics. These measures of Aβ aggregation, e.g. plaques, protofibrils, and oligomers, are medically invasive and often only available at specialized medical centers or not covered by medical insurance, and PET scans are costly. Therefore, a major goal in recent years has been to identify blood-based biomarkers that can accurately detect AD pathology with cost-effective, minimally invasive procedures.To assess the performance of plasma Aβ assays in predicting amyloid burden in the central nervous system (CNS), this review compares twenty-one different manuscripts that used measurements of 42 and 40 amino acid-long Aβ (Aβ42 and Aβ40) in plasma to predict CNS amyloid status. Methodologies that quantitate Aβ42 and 40 peptides in blood via immunoassay or immunoprecipitation-mass spectrometry (IP-MS) were considered, and their ability to distinguish participants with amyloidosis compared to amyloid PET and CSF Aβ measures as reference standards was evaluated. Recent studies indicate that some IP-MS assays perform well in accurately and precisely measuring Aβ and detecting brain amyloid aggregates.
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