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  • Albrektsson, Tomas, 1945, et al. (creator_code:aut_t)
  • Direct bone anchorage of oral implants: clinical and experimental considerations of the concept of osseointegration.
  • 1990
  • record:In_t: The International journal of prosthodontics. - 0893-2174. ; 3:1, s. 30-41
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • The term osseointegration is analyzed in relation to its theoretical and clinical definitions, and comparisons are made to other implant modalities. The term osseointegration has a clear clinical meaning, but there is doubt about its precise usage in an experimental setting. Clinically, an implant can be described as osseointegrated if there is no discernable movement when force is applied to the fixture. This is in contrast to implants surrounded by fibrous connective tissue, which move within soft tissue. Newly developed laboratory techniques may be used in the future to precisely characterize osseointegration in the laboratory.
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  • Albrektsson, Tomas, 1945, et al. (creator_code:aut_t)
  • Initial and long-term crestal bone responses to modern dental implants
  • 2017
  • record:In_t: Periodontology 2000. - : Wiley. - 0906-6713 .- 1600-0757. ; 73:1, s. 41-50
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • Successful osseointegration is the result of a controlled foreign body reaction to dental implants. Osseointegrated implants have demonstrated excellent long-term survivability, although they may be subject to limited marginal bone loss. Marginal bone loss during the first few years after implant placement seldom represents disease, but is instead the result of an adaptive bone response to surgical trauma and implant loading. It is not uncommon for implants with early marginal bone loss to enter a long-lasting state of bone stability. Extensive bone resorption after the first year is generally due to an exacerbation of adverse body reactions caused by non-optimal implant components, adverse surgery or prosthodontics and/or compromised patient factors. Disease in the form of peri-implantitis is a late complication that affects some implants with suppuration and rapid loss of crestal bone, and is probably caused by bacterial pathogens and immunological reactions. Unfortunately, the literature is not consistent with respect to the type or magnitude of clinical implant problems, including how they are defined and diagnosed. If the peri-implantitis diagnosis is confined to cases with infection, suppuration and significant bone loss, the frequency of the disease is relatively low, which is in sharp contrast to the frequencies reported with unrealistic definitions of peri-implantitis. We suggest that when modern implants are placed by properly trained individuals, only 1–2% of implants show true peri-implantitis during follow-up periods of 10 years or more. Peri-implantitis must be separated from the initial and self-limiting marginal bone loss.
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5.
  • Albrektsson, Tomas, 1945, et al. (creator_code:aut_t)
  • State of the art in oral implants.
  • 1991
  • record:In_t: Journal of clinical periodontology. - : Wiley. - 0303-6979 .- 1600-051X. ; 18:6, s. 474-81
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • Uncontrolled oral implant devices are still being widely used. The documentation of most oral implant systems is poorly backed up or not followed up for an adequate time period. Success rates are being quoted without reference to any defined success criteria. Frequently used oral implant designs such as the Core-Vent, IMZ and Calcitek hydroxyapatite coated implants are in neither case supported by any adequate clinical reports from minimally 5-years of follow-up. Other implant systems such as the ITI, some subperiosteal designs and the Tübingen implant demonstrate well-controlled and acceptable 5-year data but are not followed up in a sufficient number or have demonstrated less good results in the 10-year evaluation. The Small transosteal staple has been adequately reported for more than 10 years of follow-up, whereas the Brånemark implant is the only endosseous design that has demonstrated acceptable 15-year success rates.
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6.
  • Chrcanovic, Bruno, et al. (creator_code:aut_t)
  • Bone Quality and Quantity and Dental Implant Failure: A Systematic Review and Meta-analysis
  • 2017
  • record:In_t: International Journal of Prosthodontics. - : Quintessence Publishing. - 0893-2174 .- 1942-4426 .- 1139-9791. ; 30:3, s. 219-237
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • Purpose: The aim of this study was to test the null hypothesis that there is no difference in implant failure rates, marginal bone loss, and postoperative infection for implants inserted in bone with different qualities and quantities according to the classification of Lekholm and Zarb. Materials and Methods: An electronic search was undertaken in January 2015 for randomized and nonrandomized human clinical studies. Results: A total of 94 publications were included. When bone sites of different qualities were considered, the results suggested the following comparative implant failure rates: 1 > 2, 1 > 3, 3 > 2, 4 > 1, 4 > 2, and 4 > 3. Sensitivity analyses suggested that when implants inserted in bone qualities 1 and 2 and 1 and 3 were compared, oxidized and sandblasted/acid-etched surfaces showed a decrease in significant difference in failures compared with turned implants. The same is not true for failure of implants inserted in bone quality 4 compared to failure of implants in all other bone qualities. When bone sites of different quantities were considered, the following comparative implant failure rates were observed: A > B, A > C, A < D, B < C, B < D, C < D, E > A, E > B, E > C, E > D. Due to insufficient information, meta-analyses for the outcomes postoperative infection and marginal bone loss were not performed. Conclusion: Sites with poorer bone quality and lack of bone volume may statistically affect implant failure rates. Implant surfaces may play a role in failure of implants in different bone qualities.
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7.
  • Chrcanovic, Bruno, et al. (creator_code:aut_t)
  • Periodontally compromised vs. periodontally healthy patients and dental implants: A systematic review and meta-analysis.
  • 2014
  • record:In_t: Journal of dentistry. - : Elsevier BV. - 1879-176X .- 0300-5712. ; 42:12
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • To test the null hypothesis of no difference in the implant failure rates, postoperative infection, and marginal bone loss for the insertion of dental implants in periodontally compromised patients (PCPs) compared to the insertion in periodontally healthy patients (PHPs), against the alternative hypothesis of a difference.
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8.
  • Chrcanovic, Bruno, et al. (creator_code:aut_t)
  • Smoking and dental implants: A systematic review and meta-analysis.
  • 2015
  • record:In_t: Journal of dentistry. - : Elsevier BV. - 1879-176X .- 0300-5712. ; 43:5, s. 487-498
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • Recent studies implicate smoking as a significant factor in the failure of dental implants. This review aims to test the null hypothesis of no difference in the implant failure rates, risk of postoperative infection, and marginal bone loss for smokers versus non-smokers, against the alternative hypothesis of a difference.
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9.
  • Chrcanovic, Bruno, et al. (creator_code:aut_t)
  • Tilted versus axially placed dental implants: A meta-analysis.
  • 2015
  • record:In_t: Journal of Dentistry. - : Elsevier BV. - 0300-5712 .- 1879-176X. ; 43:2
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • The purpose of the present review was to test the null hypothesis of no difference in the implant failure rate, marginal bone loss, and postoperative infection for patients being rehabilitated by tilted or by axially placed dental implants, against the alternative hypothesis of a difference.
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10.
  • Dohan Ehrenfest, David, et al. (creator_code:aut_t)
  • Classification of osseointegrated implant surfaces: materials, chemistry and topography
  • 2010
  • record:In_t: Trends in Biotechnology. - : Elsevier BV. - 0167-7799. ; 28:4, s. 198-206
  • swepub:Mat_researchreview_t (swepub:level_refereed_t)abstract
    • Since the founding of the osseointegration concept, the characteristics of the interface between bone and implant, and possible ways to improve it, have been of particular interest in dental and orthopaedic implant research. Making use of standardized tools of analysis and terminology, we present here a standardized characterization code for osseointegrated implant surfaces. This code describes the chemical composition of the surface, that is, the core material, such as titanium, and its chemical or biochemical modification through impregnation or coating. This code also defines the physical surface features, at the micro- and nanoscale, such as microroughness, microporosity, nanoroughness, nanotubes, nanoparticles, nanopatterning and fractal architecture. This standardized classification system will allow to clarify unambiguously the identity of any given osseointegrated surface and help to identify the biological outcomes of each surface characteristic. Copyright © 2009 Elsevier Ltd. All rights reserved.
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