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- Ellegård, Lars, 1958, et al.
(författare)
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Biochemical indices to evaluate nutritional support for malignant disease.
- 2008
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Ingår i: Clinica chimica acta; international journal of clinical chemistry. - : Elsevier BV. - 0009-8981. ; 390:1-2, s. 23-7
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Forskningsöversikt (refereegranskat)abstract
- Malignant diseases are often complicated by malnutrition, and nutritional support is often indicated. Nutritional support should be evaluated primarily by improved clinical outcome. During nutritional support as artificial nutrition, monitoring is of paramount importance. Several biochemical markers are frequently used to monitor nutritional status. Most widely used are serum levels of albumin, transferrin, and transthyretin which are subnormal in malnutrition. Unfortunately, monitoring nutritional support by biochemical indices in malignant disease is complicated by the pathophysiology of cancer related malnutrition. Systemic inflammation is central in this context as it perturbs most of the traditional biochemical indices, and is inversely correlated to survival. In addition, systemic inflammation explains variations in body composition. Thus, the most important biochemical index to be measured in malignant disease is the assessment of systemic inflammatory response, preferably by high-resolution CRP, and if normal, common biochemical indices such as albumin, transferrin or transthyretin might be used. Preferentially, indices with high turnover should be used. IGF-1 is an index well suited for assessing nutrition support in conventional malnutrition, but its use in malignant disease is still unproved. If APPR is prevalent, methods detecting changes in body composition, performance or physical activity might offer better options to evaluate nutritional support.
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- Ellegård, Lars, 1958, et al.
(författare)
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Dietary plant sterols and cholesterol metabolism
- 2007
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Ingår i: Nutrition Reviews. - 0029-6643. ; 65:1, s. 39-45
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Forskningsöversikt (refereegranskat)abstract
- Plant sterols, naturally occurring in foods of plant origin, reduce cholesterol absorption. Experimental studies show plant sterols to be an important part of the serum-cholesterol lowering effect of certain diets and dietary components. Epidemiological data show that individuals with higher intakes of plant sterols from their habitual diets have lower serum-cholesterol levels. To date, the role of naturally occurring plant sterols for lowering serum cholesterol has probably been underestimated. The consumption of dietary plant sterols should be a part of dietary advice to patients with hypercholesterolemia and the general public for the prevention and management of coronary heart disease.
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