Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "LAR1:gu ;pers:(Ohlsson Claes 1965);pers:(Svensson Johan 1964)"

Sökning: LAR1:gu > Ohlsson Claes 1965 > Svensson Johan 1964

  • Resultat 1-10 av 12
  • [1]2Nästa
Sortera/gruppera träfflistan
  • Johansson, Per, 1966-, et al. (författare)
  • Mild dementia is associated with increased adrenal secretion of cortisol and precursor sex steroids in women.
  • 2011
  • Ingår i: Clinical endocrinology. - 1365-2265. ; 75:3, s. 301-308
  • Tidskriftsartikel (refereegranskat)abstract
    • Context: Sex steroid levels decrease with increasing age, but little is known whether this is of importance for the age-related decline in cognitive function. Design and Patients: A cross-sectional study of 50 (26 men) consecutive patients under primary evaluation of cognitive impairment (D group) and 18 (9 men) matched healthy controls (C group). Measurements: Sex steroid and precursor levels were determined in serum and when measurable, in cerebrospinal fluid (CSF) using gas chromatography/mass spectroscopy (GC-MS) or liquid chromatography/mass spectroscopy (LC-MS). Sex hormone binding globulin (SHBG) and cortisol concentrations were measured using conventional assays. Results: Patients in the D group had higher 24-h urine cortisol level and increased serum levels of dehydroepiandrosterone (DHEA) and its sulfate ester DHEAS, androsterone (ADT), and estrone (E1) and its sulfate ester E1S, compared to the controls. When men and women were analyzed separately, increased serum concentrations of E1 and E1S were observed in both D men and D women whereas increased levels of other sex steroids and cortisol were seen only in D women. Conclusions: In both D men and women, serum E1 and E1S levels were increased whereas other changes were gender-specific and only seen in D women. Further studies are needed to determine whether these changes are a cause of, or merely a consequence of, cognitive impairment in elderly subjects.
  • Movérare-Skrtic, Sofia, 1976-, et al. (författare)
  • Serum insulin-like growth factor-I concentration is associated with leukocyte telomere length in a population-based cohort of elderly men.
  • 2009
  • Ingår i: The Journal of clinical endocrinology and metabolism. - 1945-7197. ; 94:12, s. 5078-84
  • Tidskriftsartikel (refereegranskat)abstract
    • CONTEXT: Both leukocyte telomere length and IGF-I are associated with the aging process. A previous in vitro study suggested that IGF-I may modulate telomerase activity in white blood cells, but little is known whether these two systems interact in vivo. PATIENTS AND METHODS: Leukocyte telomere length was determined using a quantitative PCR assay in 2744 elderly men (mean age 75.5 yr, range 69-81 yr) included in the population-based Osteoporotic Fractures in Men-Sweden study. Serum IGF-I concentration was measured using RIA. RESULTS: Subjects with a leukocyte telomere length in the lowest tertile group had lower serum IGF-I concentration than subjects in the two tertile groups with longer telomere lengths (P = 0.005). Logistic regression analyses showed that a higher serum IGF-I concentration was associated with a significantly reduced risk of having a leukocyte telomere length in the lowest tertile group and also after adjustment for multiple covariates (P < 0.01). Multivariate linear regression analyses demonstrated that tertile of leukocyte telomere length was positively, whereas age was negatively, associated with serum IGF-I concentration in elderly men. CONCLUSIONS: In this large population-based, cross-sectional study, leukocyte telomere length was positively associated with serum IGF-I concentration in elderly men. The mechanisms underlying the association between serum IGF-I concentration and leukocyte telomere length remain to be determined.
  • Ohlsson, Claes, 1965-, et al. (författare)
  • The role of liver-derived insulin-like growth factor-I.
  • 2009
  • Ingår i: Endocrine reviews. - 1945-7189. ; 30:5, s. 494-535
  • Forskningsöversikt (refereegranskat)abstract
    • IGF-I is expressed in virtually every tissue of the body, but with much higher expression in the liver than in any other tissue. Studies using mice with liver-specific IGF-I knockout have demonstrated that liver-derived IGF-I, constituting a major part of circulating IGF-I, is an important endocrine factor involved in a variety of physiological and pathological processes. Detailed studies comparing the impact of liver-derived IGF-I and local bone-derived IGF-I demonstrate that both sources of IGF-I can stimulate longitudinal bone growth. We propose here that liver-derived circulating IGF-I and local bone-derived IGF-I to some extent have overlapping growth-promoting effects and might have the capacity to replace each other (= redundancy) in the maintenance of normal longitudinal bone growth. Importantly, and in contrast to the regulation of longitudinal bone growth, locally derived IGF-I cannot replace (= lack of redundancy) liver-derived IGF-I for the regulation of a large number of other parameters including GH secretion, cortical bone mass, kidney size, prostate size, peripheral vascular resistance, spatial memory, sodium retention, insulin sensitivity, liver size, sexually dimorphic liver functions, and progression of some tumors. It is clear that a major role of liver-derived IGF-I is to regulate GH secretion and that some, but not all, of the phenotypes in the liver-specific IGF-I knockout mice are indirect, mediated via the elevated GH levels. All of the described multiple endocrine effects of liver-derived IGF-I should be considered in the development of possible novel treatment strategies aimed at increasing or reducing endocrine IGF-I activity.
  • Svensson, Johan, 1964-, et al. (författare)
  • Effects of growth hormone and its secretagogues on bone.
  • 2001
  • Ingår i: Endocrine. - 0969-711X. ; 14:1, s. 63
  • Tidskriftsartikel (refereegranskat)abstract
    • The growth hormone (GH)/insulin-like growth factor-1 axis is not only of importance for linear body growth during childhood, but it is also one of the major determinants of adult bone mass. Studies show that GH treatment increases bone mass in rodents as well as in adult GH-deficient humans, but the effect of GH treatment on bone mass in healthy humans has so far not been impressive. Recently, a new class of GH secretagogues (GHSs) has been developed. In humans, GHS treatment affects biochemical markers of bone turnover and increases growth velocity in selected short children with or without GH deficiency. In rodents, GHS treatment increase bone mineral content, but it has not yet been shown that GHS treatment can affect bone mass in adult humans.
  • Svensson, Johan, 1964-, et al. (författare)
  • Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice.
  • 2006
  • Ingår i: The Journal of endocrinology. - 0022-0795. ; 189:3, s. 617
  • Tidskriftsartikel (refereegranskat)abstract
    • IGF-I is a neuroprotective hormone, and neurodegenerative disorders, including Alzheimer's disease, have been associated with decreased serum IGF-I concentration. In this study, IGF-I production was inactivated in the liver of adult mice (LI-IGF-I(-/-)), resulting in an approximately 80-85% reduction of circulating IGF-I concentrations. In young (6-month-old) mice there was no difference between the LI-IGF-I(-/-) and the control mice in spatial learning and memory as measured using the Morris water maze test. In old (aged 15 and 18 months) LI-IGF-I(-/-) mice, however, the acquisition of the spatial task was slower than in the controls. Furthermore, impaired spatial working as well as reference memory was observed in the old LI-IGF(-/-) mice. Histochemical analyses revealed an increase in dynorphin and enkephalin immunoreactivities but decreased mRNA levels in the hippocampus of old LI-IGF-I(-/-) mice. These mice also displayed astrocytosis and increased metabotropic glutamate receptor 7a-immunoreactivity. These neurochemical disturbances suggest synaptic dysfunction and early neurodegeneration in old LI-IGF-I(-/-) mice. The decline in serum IGF-I with increasing age may therefore be important for the age-related decline in memory function.
  • Svensson, Johan, 1964-, et al. (författare)
  • Liver-derived IGF-I regulates exploratory activity in old mice.
  • 2005
  • Ingår i: American journal of physiology. Endocrinology and metabolism. - 0193-1849. ; 289:3, s. 466-73
  • Tidskriftsartikel (refereegranskat)abstract
    • Growth hormone (GH) replacement in hypopituitary patients improves well-being and initiative. Experimental studies indicate that these psychic effects may be reflected in enhanced locomotor activity in mice. It is unknown whether these phenomena are mediated directly by GH or by circulating IGF-I. IGF-I production in the liver was inactivated at 6-10 wk of age (LI-IGF-I-/- mice), resulting in an 80-85% reduction of circulating IGF-I, and, secondary to this, increased GH secretion. Using activity boxes on three different occasions during 1 wk, 6-mo-old LI-IGF-I-/- mice had similar activity levels, and 14-mo-old mice had a moderate but significant decrease in activity level, compared with control mice. At 20 mo of age, the LI-IGF-I-/- mice displayed a more prominent decrease in activity level with decreased horizontal activity throughout the test period, and at day 1, there were several signs of an altered habituation process with different time patterns of locomotor activity and horizontal activity compared with the control mice. At days 3 and 5, rearing activity was lower in the 20-mo-old LI-IGF-I-/- mice. Anxiety level was unaffected in all age groups, as measured using the Montgomery's elevated plus-maze. In conclusion, old LI-IGF-I-/- mice displayed a decrease in both horizontal and rearing (exploratory) activity level and an altered habituation process. These results indicate that liver-derived IGF-I mediates at least part of the effects of GH on exploratory activity in mice.
  • Svensson, Johan, 1964-, et al. (författare)
  • Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression.
  • 2007
  • Ingår i: The Journal of endocrinology. - 0022-0795. ; 193:3, s. 359-66
  • Tidskriftsartikel (refereegranskat)abstract
    • The GH/-IGF-I axis is important for kidney size and function and may also be involved in the development of renal failure. In this study, the role of liver-derived endocrine IGF-I for kidney size and function was investigated in mice with adult liver-specific IGF-I inactivation (LI-IGF-I(-/-) mice). These mice have an 80-85% reduction of serum IGF-I level and compensatory increased GH secretion. Seven-month-old as well as 24-month-old LI-IGF-I(-/-) mice had decreased kidney weight. Glomerular filtration rate, assessed using creatinine clearance as well as creatinine clearance corrected for body weight, was unchanged. The 24-h urine excretion of sodium and potassium was increased in the LI-IGF-I(-/-) mice. In the 24-month-old mice, there was no between-group difference in kidney morphology. Microarray and real-time PCR (RT-PCR) analyses showed a high renal expression of IGF-II in the control mice, whereas in the LI-IGF-I(-/-) mice, there was a tissue-specific decrease in the renal IGF-II mRNA levels (-79%, P < 0.001 vs controls using RT-PCR). In conclusion, deficiency of circulating liver-derived IGF-I in mice results, despite an increase in GH secretion, in a global symmetrical decrease in kidney size, increased urinary sodium and potassium excretion, and a clear down regulation of renal IGF-II expression. However, the LI-IGF-I(-/-) mice did not develop kidney failure or nephrosclerosis. One may speculate that liver-derived endocrine IGF-I induces renal IGF-II expression, resulting in symmetrical renal growth.
  • Svensson, Johan, 1964-, et al. (författare)
  • Liver-derived igf-I regulates mean life span in mice
  • 2011
  • Ingår i: PLoS ONE. - 1932-6203. ; 6:7
  • Tidskriftsartikel (refereegranskat)abstract
    • Transgenic mice with low levels of global insulin-like growth factor-I (IGF-I) throughout their life span, including pre- and postnatal development, have increased longevity. This study investigated whether specific deficiency of liver-derived, endocrine IGF-I is of importance for life span.
  • Svensson, Johan, 1964-, et al. (författare)
  • Liver-derived IGF1 enhances the androgenic response in prostate.
  • 2008
  • Ingår i: The Journal of endocrinology. - 1479-6805. ; 199:3, s. 489-97
  • Tidskriftsartikel (refereegranskat)abstract
    • Both IGF1 and androgens are major enhancers of prostate growth and are implicated in the development of prostate hyperplasia and cancer. The aim of the present study was to investigate whether liver-derived endocrine IGF1 modulates the androgenic response in prostate. Mice with adult, liver-specific inactivation of IGF1 (LI-IGF1(-/-) mice) displayed an approximately 80% reduction in serum IGF1 levels associated with decreased prostate weight compared with control mice (anterior prostate lobe -19%, P<0.05; dorsolateral prostate (DLP) lobe -35%, P<0.01; ventral prostate (VP) lobe -47%, P<0.01). Reduced androgen receptor (Ar) mRNA and protein levels were observed in the VP lobe (-34% and -30% respectively, both P<0.05 versus control mice). Analysis of prostate morphology showed reductions in both the glandular and fibromuscular compartments of the VP and DLP lobes that were proportional to the reductions in the weights of these lobes. Immunohistochemistry revealed reduced intracellular AR immunoreactivity in the VP and DLP lobes. The non-aromatizable androgen dihydrotestosterone increased VP weight to a lesser extent in orchidectomized (ORX) LI-IGF1(-/-) mice than in ORX controls (-40%, P<0.05 versus control mice). In conclusion, deficiency of liver-derived IGF1 reduces both the glandular and fibromuscular compartments of the prostate, decreases AR expression in prostate, and reduces the stimulatory effect of androgens on VP weight. These findings may explain, at least in part, the well-known clinical association between serum IGF1 levels and conditions with abnormal prostate growth.
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 12
  • [1]2Nästa
fritt online (1)
Typ av publikation
tidskriftsartikel (11)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (12)
Jansson, John-Olov, ... (7)
Sjögren, Klara, 1970 ... (6)
Isaksson, Olle, 1943 ... (5)
Bengtsson, Bengt-Åke ... (3)
visa fler...
Mohan, Subburaman (3)
Tivesten, Åsa, 1969- ... (3)
Andersson, Niklas, 1 ... (2)
Movérare-Skrtic, Sof ... (2)
Isgaard, Jörgen, 195 ... (2)
Engel, Jörgen, 1942- ... (2)
Dickson, Suzanne L., ... (2)
Lall, S (2)
Rømer, J (2)
Ahnfelt-Rønne, I (2)
Diez, M (1)
Blennow, Kaj, 1958-, (1)
Zetterberg, Henrik, ... (1)
Söderpalm, Bo, 1959- ... (1)
Hokfelt, T (1)
Hökfelt, Tomas (1)
Karlsson, Magnus K (1)
Mellström, Dan, 1945 ... (1)
Bergström, Göran, 19 ... (1)
Hansson, Oskar (1)
Wallin, Anders, 1950 ... (1)
Ljunggren, Östen, (1)
Vanderschueren, Dirk (1)
Archer, Trevor, 1949 ... (1)
Ljunggren, Osten (1)
Mölne, Johan, 1958-, (1)
Murphy, G (1)
Shao, Ruijin, 1964-, (1)
Labrie, Fernand (1)
Lagerquist, Marie, 1 ... (1)
Mattsson, Niklas, 19 ... (1)
Kindblom, Jon, 1969- ... (1)
Tivesten, A (1)
Orwoll, Eric (1)
Johansson, Jan-Ove, ... (1)
Wass, Caroline, 1976 ... (1)
Fäldt, Jenny, 1971-, (1)
Johansson, Per, 1966 ... (1)
Venken, Katrien (1)
Krupa, D (1)
Wyss, D (1)
Cerchio, K (1)
Polvino, W (1)
Gertz, B (1)
visa färre...
Göteborgs universitet (12)
Lunds universitet (2)
Chalmers tekniska högskola (1)
Uppsala universitet (1)
Karolinska Institutet (1)
Engelska (12)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (12)


pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy